Information flow and optimization in transcriptional regulation

In the simplest view of transcriptional regulation, the expression of a gene is turned on or off by changes in the concentration of a transcription factor (TF). We use recent data on noise levels in gene expression to show that it should be possible to transmit much more than just one regulatory bit...

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Vydáno v:Proceedings of the National Academy of Sciences - PNAS Ročník 105; číslo 34; s. 12265
Hlavní autoři: Tkacik, Gasper, Callan, Jr, Curtis G, Bialek, William
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 26.08.2008
Témata:
Animals
DNA-Binding Proteins
Drosophila - genetics
Drosophila Proteins
Gene Expression Regulation
Gene Regulatory Networks
Homeodomain Proteins
Information Theory
Transcription Factors
Transcription, Genetic
ISSN:1091-6490, 1091-6490
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Shrnutí:In the simplest view of transcriptional regulation, the expression of a gene is turned on or off by changes in the concentration of a transcription factor (TF). We use recent data on noise levels in gene expression to show that it should be possible to transmit much more than just one regulatory bit. Realizing this optimal information capacity would require that the dynamic range of TF concentrations used by the cell, the input/output relation of the regulatory module, and the noise in gene expression satisfy certain matching relations, which we derive. These results provide parameter-free, quantitative predictions connecting independently measurable quantities. Although we have considered only the simplified problem of a single gene responding to a single TF, we find that these predictions are in surprisingly good agreement with recent experiments on the Bicoid/Hunchback system in the early Drosophila embryo and that this system achieves approximately 90% of its theoretical maximum information transmission.
Bibliografie:ObjectType-Article-1
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ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.0806077105