Information flow and optimization in transcriptional regulation

In the simplest view of transcriptional regulation, the expression of a gene is turned on or off by changes in the concentration of a transcription factor (TF). We use recent data on noise levels in gene expression to show that it should be possible to transmit much more than just one regulatory bit...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 34; p. 12265
Main Authors:	Tkacik, Gasper, Callan, Jr, Curtis G, Bialek, William
Format:	Journal Article
Language:	English
Published:	United States 26.08.2008
Subjects:	Animals DNA-Binding Proteins Drosophila - genetics Drosophila Proteins Gene Expression Regulation Gene Regulatory Networks Homeodomain Proteins Information Theory Transcription Factors Transcription, Genetic
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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