Effects of curcumin and/or coenzyme Q10 supplementation on metabolic control in subjects with metabolic syndrome: a randomized clinical trial

Background Metabolic syndrome (MetS) as a cluster of conditions including hyperlipidemia, hypertension, hyperglycemia, insulin resistance, and abdominal obesity is linked to cardiovascular diseases and type 2 diabetes. Evidence suggested that intake of curcumin and coenzyme Q10 may have therapeutic...

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Veröffentlicht in:Nutrition journal Jg. 21; H. 1; S. 62
Hauptverfasser: Sangouni, Abbas Ali, Taghdir, Maryam, Mirahmadi, Javad, Sepandi, Mojtaba, Parastouei, Karim
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 03.10.2022
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
blood glucose
Blood pressure
Body composition
Body mass index
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Cellulose acetate
Cholesterol
Clinical Nutrition
Clinical trials
Coenzyme Q10
Coenzymes
Curcumin
Diabetes
Diabetes mellitus (non-insulin dependent)
diastolic blood pressure
Dosage and administration
Dyslipidemia
Glucose
glycemic control
Health aspects
Health care
Health Promotion and Disease Prevention
High density lipoprotein
Hyperglycemia
Hyperlipidemia
Hypertension
Insulin
Insulin resistance
Kidney diseases
Laboratories
Lipid profile
Lipids
Low density lipoprotein
Medicine
Medicine & Public Health
Metabolic disorders
Metabolic syndrome
Metabolic syndrome X
noninsulin-dependent diabetes mellitus
Obesity
Placebos
Questionnaires
randomized clinical trials
Supplements
systolic blood pressure
therapeutics
triacylglycerols
Turmeric
waist circumference
Weight control
Womens health
Iran
Lipid profile
Curcumin
Blood pressure
Metabolic syndrome
Coenzyme Q10
Body composition
ISSN:1475-2891, 1475-2891
Online-Zugang:Volltext
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Zusammenfassung:Background Metabolic syndrome (MetS) as a cluster of conditions including hyperlipidemia, hypertension, hyperglycemia, insulin resistance, and abdominal obesity is linked to cardiovascular diseases and type 2 diabetes. Evidence suggested that intake of curcumin and coenzyme Q10 may have therapeutic effects in the management of MetS. Aims We investigated the effects of curcumin and/or coenzyme Q10 supplementation on metabolic syndrome components including systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-c) and fasting plasma glucose (FPG) as primary outcomes, and total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c) and body mass index (BMI) as secondary outcomes in subjects with MetS. Methods In this 2 × 2 factorial, randomized, double-blinded, placebo-controlled study, 88 subjects with MetS were randomly assigned into four groups including curcumin plus placebo (CP), or coenzyme Q10 plus placebo (QP), or curcumin plus coenzyme Q10 (CQ), or double placebo (DP) for 12 weeks. Results The CP group compared with the three other groups showed a significant reduction in HDL-c ( P  = 0.001), TG ( P  <  0.001), TC ( P  <  0.001), and LDL-c ( P  <  0.001). No significant differences were seen between the four groups in terms of SBP, DBP, FPG, WC, BMI and weight. Conclusion Curcumin improved dyslipidemia, but had no effect on body composition, hypertension and glycemic control. Furthermore, coenzyme Q10 as well as the combination of curcumin and coenzyme Q10 showed no therapeutic effects in subjects with MetS. The trial was registered on 09/21/2018 at the Iranian clinical trials website (IRCT20180201038585N2), URL: https://www.irct.ir/trial/32518 .
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ISSN:1475-2891
1475-2891
DOI:10.1186/s12937-022-00816-7