Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic

Thrombolysis with tissue-type plasminogen activator (tPA) is used for the treatment of patients with acute ischemic stroke. However, a growing body of evidence indicates that, besides the unquestionable benefit from its thrombolytic activity, tPA also has a deleterious effect on the ischemic brain i...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) Jg. 32; H. 1; S. 48 - 55
Hauptverfasser:	Yepes, Manuel, Roussel, Benoit D., Ali, Carine, Vivien, Denis
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Amsterdam Elsevier Ltd 01.01.2009 Elsevier Elsevier Sequoia S.A
Schlagworte:	Animals Biological and medical sciences Brain Brain Ischemia - drug therapy Fibrinolytic Agents - pharmacology Fibrinolytic Agents - therapeutic use Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Humans Life Sciences Medical sciences Neurology Neurons Neurons and Cognition Neurosciences Stroke Tissue Plasminogen Activator - pharmacology Tissue Plasminogen Activator - therapeutic use Tissues Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs Human Cerebral infarction Nervous system diseases Stroke Central nervous system Cardiovascular disease Review Permeability Cerebral disorder Encephalon Vascular disease Treatment Central nervous system disease Brain ischemia Cerebral edema Cerebrovascular disease
ISSN:	0166-2236, 1878-108X
Online-Zugang:	Volltext
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