Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci....

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Published in:	Nature (London) Vol. 604; no. 7906; pp. 502 - 508
Main Authors:	Trubetskoy, Vassily, Qi, Ting, Bryois, Julien, Chen, Chia-Yen, Magnusson, Sigurdur, Kim, Minsoo, Adams, Mark, Agartz, Ingrid, Agerbo, Esben, Athanasiu, Lavinia, Bacanu, Silviu A., Calkins, Monica E., Carr, Vaughan J., Consoli, Angèle, Costas, Javier, Davis, Kenneth L., Degenhardt, Franziska, Dickerson, Faith, Frustaci, Alessandra, Giegling, Ina, Goldstein, Jacqueline I., González Peñas, Javier, Hayward, Caroline, Howrigan, Daniel P., Ikeda, Masashi, Kam-Thong, Tony, Kamatani, Yoichiro, Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kubo, Michiaki, Lazzeroni, Laura C., Lehrer, Douglas S., Li, Miaoxin, Liu, Chih-Min, Loughland, Carmel M., Mallet, Jacques, Mattheisen, Manuel, McCarley, Robert W., Meier, Sandra, Milani, Lili, Milanova, Vihra, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Olincy, Ann, Papadimitriou, George N., Parellada, Mara, Paunio, Tiina, Pellegrino, Renata, Radant, Allen D., Saker-Delye, Safaa, Sanjuan, Julio, Savitz, Adam, Seidman, Larry J., Sim, Kang, Stain, Helen J., Streit, Fabian, Strengman, Eric, Ta, Thi Minh Tam, Terao, Chikashi, Toncheva, Draga, Veijola, Juha, Waddington, John, Walter, Henrik, Webb, Bradley T., Wu, Jing Qin, Xu, Zhida, Ayub, Muhammad, Bertolino, Alessandro, Buccola, Nancy G., Byerley, William F., Hwu, Hai-Gwo, McCarroll, Steven A., Neil, Amanda L., Smoller, Jordan W., Vilella, Elisabet, Xu, Shuhua, Braff, David, Buxbaum, Joseph D., Cichon, Sven, Ehrenreich, Hannelore, Escott-Price, Valentina, Esko, Tõnu, Iwata, Nakao, Kirov, George, Lee, Jimmy, Li, Qingqin S., Malhotra, Anil K., Malhotra, Dheeraj, McQuillin, Andrew, Morgan, Vera A., Nöthen, Markus M., Saka, Meram C., Sanders, Alan R., Serretti, Alessandro, van Os, Jim, Yu, Xin, Neale, Benjamin M., Ripke, Stephan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 21.04.2022 Nature Publishing Group
Subjects:	45/43 631/208/205/2138 631/378/1689 631/378/2583 692/699/476/1799 Alleles Biological activity Central nervous system Consortia Datasets Disorders Gender differences Gene loci Gene mapping Genes Genetic Predisposition to Disease - genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics Glutamate receptors Heritability Humanities and Social Sciences Humans Liability Life Sciences Mental disorders multidisciplinary Neural coding Neurodevelopmental disorders Ontology Pathophysiology Peptide mapping Polymorphism, Single Nucleotide - genetics Schizophrenia Schizophrenia - genetics Science Science (multidisciplinary) Synaptic transmission
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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