Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma. We hypothesized that inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and are associated with different patterns of inflammatory proteins i...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 125; no. 5; pp. 1028 - 1036.e13
Main Authors:	Hastie, Annette T., Moore, Wendy C., Meyers, Deborah A., Vestal, Penny L., Li, Huashi, Peters, Stephen P., Bleecker, Eugene R.
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01.05.2010 Elsevier Elsevier Limited
Subjects:	Adolescent Adult Allergy and Immunology Asthma Asthma - physiopathology Asthma phenotypes BDNF Biological and medical sciences CCL18 CCL20 Child Child, Preschool Chronic obstructive pulmonary disease, asthma CXCL13 Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Fundamental immunology Granulocytes - cytology Humans Immunopathology Inflammation - immunology Inflammation - physiopathology Inflammation Mediators - analysis Linear Models Male Medical sciences Meetings Methods Phenotype Pneumology Protein Array Analysis protein microarrays Proteins Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Severity of Illness Index Sputum - cytology TNFSF14 Young Adult Asthma phenotypes TNFSF14 BDNF CCL20 EGF PARC SARP CXCL13 FVC BLC ICS MIP-3α MCP protein microarrays CCL18 SAM Forced vital capacity Epidermal growth factor B-lymphocyte chemoattractant/CXCL13 Severe Asthma Research Program of the National Heart, Lung, and Blood Institute Inhaled corticosteroid Macrophage inflammatory protein 3α/CCL20 TNF superfamily factor 14/LIGHT, Lymphotoxin homologous, Inducible expression, competes with HSV Glycoprotein D for HVEM receptor on T lymphocytes Pulmonary and regulated chemokine/CCL18 Brain-derived neurotrophic factor Monocyte chemoattractant protein Significance Analysis of Microarrays Human Lung disease Immunopathology Chemokine CC Exodus Respiratory disease Granulocyte LIGHT ligand CXCLl3 Inflammation Protein microarray CC chemokine Protein Asthma Phenotype Immunology Sputum Bronchus disease Obstructive pulmonary disease
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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