Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia

This review provides a summary statement of recommended implementations of arterial spin labeling (ASL) for clinical applications. It is a consensus of the ISMRM Perfusion Study Group and the European ASL in Dementia consortium, both of whom met to reach this consensus in October 2012 in Amsterdam....

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Published in:Magnetic resonance in medicine Vol. 73; no. 1; pp. 102 - 116
Main Authors: Alsop, David C., Detre, John A., Golay, Xavier, Günther, Matthias, Hendrikse, Jeroen, Hernandez-Garcia, Luis, Lu, Hanzhang, MacIntosh, Bradley J., Parkes, Laura M., Smits, Marion, van Osch, Matthias J. P., Wang, Danny J. J., Wong, Eric C., Zaharchuk, Greg
Format: Journal Article
Language:English
Published: United States Blackwell Publishing Ltd 01.01.2015
Wiley Subscription Services, Inc
Subjects:
arterial spin labeling
Blood Flow Velocity
Brain - physiopathology
cerebral blood flow
Cerebrovascular Circulation
Dementia - diagnosis
Dementia - physiopathology
European Union
Humans
Magnetic Resonance Angiography - standards
Neurology - standards
perfusion
Practice Guidelines as Topic
Spin Labels
cerebral blood flow
arterial spin labeling
perfusion
ISSN:0740-3194, 1522-2594, 1522-2594
Online Access:Get full text
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Summary:This review provides a summary statement of recommended implementations of arterial spin labeling (ASL) for clinical applications. It is a consensus of the ISMRM Perfusion Study Group and the European ASL in Dementia consortium, both of whom met to reach this consensus in October 2012 in Amsterdam. Although ASL continues to undergo rapid technical development, we believe that current ASL methods are robust and ready to provide useful clinical information, and that a consensus statement on recommended implementations will help the clinical community to adopt a standardized approach. In this review, we describe the major considerations and trade‐offs in implementing an ASL protocol and provide specific recommendations for a standard approach. Our conclusion is that as an optimal default implementation, we recommend pseudo‐continuous labeling, background suppression, a segmented three‐dimensional readout without vascular crushing gradients, and calculation and presentation of both label/control difference images and cerebral blood flow in absolute units using a simplified model. Magn Reson Med 73:102–116, 2015. © 2014 Wiley Periodicals, Inc.
Bibliography:ark:/67375/WNG-XWKVBMMP-G
istex:2942C788EB7BF9A2973786D12E9423251830E9AE
NIH; Grant numbers: P41 EB015893, R01 EB014922, R01 NS081077, R01 NS066506, R01 MH084021, R01 MH080729, and R21 EB013821; Grant sponsor: Dutch Heart Association; Grant number: 2010B274
ArticleID:MRM25197
†
With endorsement by the ASNR, the ASFNR, and 245 individual investigators. Endorsement list available as Supporting Information.
Authors are listed in alphabetical order.
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SourceType-Scholarly Journals-1
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Authors are listed in alphabetical order
ISSN:0740-3194
1522-2594
1522-2594
DOI:10.1002/mrm.25197