Autoantibody against the amino acid sequence 661–680 in apo B-100 is associated with decreased carotid stenosis and cardiovascular events

Immunization with malondialdehyde (MDA)-modified peptides corresponding to the amino acid sequence between 661 and 680 in apo B-100 (p45) inhibits atherosclerosis in apo E knockout mice. The same effect can be obtained by treating the mice with recombinant anti-MDA-p45 IgG, suggesting that these ant...

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Vydáno v:Atherosclerosis Ročník 194; číslo 2; s. e188 - e192
Hlavní autoři: Fredrikson, Gunilla Nordin, Schiopu, Alexandru, Berglund, Göran, Alm, Ragnar, Shah, Prediman K., Nilsson, Jan
Médium: Journal Article
Jazyk:angličtina
Vydáno: Ireland Elsevier Ireland Ltd 01.10.2007
Témata:
Aged
Antibodies
Apolipoprotein B-100 - genetics
Apolipoprotein B-100 - immunology
Apolipoproteins
Autoantibodies - blood
Autoantibodies - immunology
Cardiology and Cardiovascular Disease
Cardiovascular
Carotid stenosis
Case-Control Studies
Clinical Medicine
Cohort Studies
Death, Sudden, Cardiac
Female
Humans
Immunoglobulin G - blood
Kardiologi och kardiovaskulära sjukdomar
Klinisk medicin
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Middle Aged
Myocardial Infarction - immunology
Peptide
Peptide Fragments - immunology
Peptides - immunology
Risk Factors
Ultrasound
Carotid stenosis
Antibodies
Apolipoproteins
Peptide
Ultrasound
ISSN:0021-9150, 1879-1484, 1879-1484
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Shrnutí:Immunization with malondialdehyde (MDA)-modified peptides corresponding to the amino acid sequence between 661 and 680 in apo B-100 (p45) inhibits atherosclerosis in apo E knockout mice. The same effect can be obtained by treating the mice with recombinant anti-MDA-p45 IgG, suggesting that these antibodies have atheroprotective effects. In the present study we analyzed if autoantibodies against p45 and MDA-p45 are related to carotid atherosclerosis and acute cardiovascular events in humans. Using a nested case control design we determined plasma levels of IgG recognizing native and MDA-modified p45 in baseline samples from 75 subjects with acute myocardial infarction or sudden cardiac death and 148 matched controls. The control group was found to have significantly higher levels of p45 IgG than the cases. Moreover, an independent association was found between high levels of MDA-p45 IgG and a low degree of carotid stenosis ( P = 0.006). There was a high degree of co-variation between IgG binding to native p45 and MDA-p45 ( r = 0.68, P < 0.0001). The associations between lower levels of autoantibodies against the apo B-100 p45 sequence and cardiovascular disease are in agreement with previous experimental studies demonstrating that these antibodies have atheroprotective effects. Our findings support the notion that the p45 sequence of apo B-100 is a potential target for immunomodulatory treatment of atherosclerosis in humans.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-9150
1879-1484
1879-1484
DOI:10.1016/j.atherosclerosis.2006.12.014