High‐throughput sequencing for biology and medicine

Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing technologies are now routinely being applied to a wide range of important topics in biology and medi...

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Vydáno v:	Molecular systems biology Ročník 9; číslo 1; s. 640 - n/a
Hlavní autoři:	Soon, Wendy Weijia, Hariharan, Manoj, Snyder, Michael P
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 2013 John Wiley & Sons, Ltd EMBO Press Nature Publishing Group Springer Nature
Témata:	Biology Biomedical Research - methods Costs Deoxyribonucleic acid DNA DNA methylation EMBO09 EMBO24 Epigenomics Gene expression Gene Expression Profiling Gene sequencing Genetic Variation Genome Genomes Genotyping High-Throughput Nucleotide Sequencing - methods high‐throughput Histones - metabolism Humans Medical research Medicine Proteins Researchers Review RNA polymerase sequencing Single-Cell Analysis technologies technologies high‐throughput medicine biology sequencing
ISSN:	1744-4292, 1744-4292
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Popis
Shrnutí:	Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing technologies are now routinely being applied to a wide range of important topics in biology and medicine, often allowing researchers to address important biological questions that were not possible before. In this review, we discuss these innovative new approaches—including ever finer analyses of transcriptome dynamics, genome structure and genomic variation—and provide an overview of the new insights into complex biological systems catalyzed by these technologies. We also assess the impact of genotyping, genome sequencing and personal omics profiling on medical applications, including diagnosis and disease monitoring. Finally, we review recent developments in single‐cell sequencing, and conclude with a discussion of possible future advances and obstacles for sequencing in biology and health. Genome sequencing technologies have advanced rapidly, dramatically decreasing cost and increasing throughput. But beyond faster and cheaper, these advances have also stimulated the development of innovative new experimental approaches, and are opening new doors in human medicine and health.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1744-4292 1744-4292
DOI:	10.1038/msb.2012.61