Enhanced platelet aggregation and activation under conditions of hypothermia

The effects on platelet function of temperatures attained during hypothermia used in cardiac surgery are controversial. Here we have performed studies on platelet aggregation in whole blood and platelet-rich plasma after stimulation with a range of concentrations of ADP, TRAP, U46619 and PAF at both...

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Bibliographic Details
Published in:	Thrombosis and haemostasis Vol. 98; no. 6; p. 1266
Main Authors:	Xavier, Ruben G, White, Ann E, Fox, Susan C, Wilcox, Robert G, Heptinstall, Stan
Format:	Journal Article
Language:	English
Published:	Germany 01.12.2007
Subjects:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Adenosine Diphosphate - metabolism Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - pharmacology Anticoagulants - pharmacology Antigens, CD - metabolism Aspirin - pharmacology Blood Platelets - drug effects Blood Platelets - immunology Blood Platelets - metabolism Blood Specimen Collection - methods Citrates - pharmacology Cold Temperature Cyclooxygenase Inhibitors - pharmacology Dose-Response Relationship, Drug Hirudins - pharmacology Humans Hypothermia, Induced In Vitro Techniques P-Selectin - metabolism Platelet Activating Factor - metabolism Platelet Activation - drug effects Platelet Aggregation - drug effects Platelet Function Tests Platelet Membrane Glycoproteins - metabolism Purinergic P2 Receptor Antagonists Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y12 Receptors, Thrombin - metabolism Tetraspanin 30 Time Factors
ISSN:	0340-6245
Online Access:	Get more information
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