Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms

Food intake is a complex behavior that can occur or cease to occur for a multitude of reasons. Decisions about where, when, what, and how much to eat are not merely reflexive responses to food-relevant stimuli or to changes in energy status. Rather, feeding behavior is modulated by various contextua...

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Veröffentlicht in:Biological psychiatry (1969) Jg. 81; H. 9; S. 748 - 756
Hauptverfasser: Kanoski, Scott E., Grill, Harvey J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.05.2017
Schlagworte:
Animals
Association Learning - physiology
Eating
Feeding
Feeding Behavior - physiology
Ghrelin - physiology
Glucagon-Like Peptide 1 - physiology
Hippocampus - physiology
Humans
Interoception - physiology
Learning
Leptin - physiology
Memory
Memory, Episodic
Neurons - physiology
Obesity
Psychiatric/Mental Health
Reward
Ventral hippocampus
Learning
Obesity
Ventral hippocampus
Reward
Memory
Feeding
ISSN:0006-3223, 1873-2402, 1873-2402
Online-Zugang:Volltext
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Zusammenfassung:Food intake is a complex behavior that can occur or cease to occur for a multitude of reasons. Decisions about where, when, what, and how much to eat are not merely reflexive responses to food-relevant stimuli or to changes in energy status. Rather, feeding behavior is modulated by various contextual factors and by previous experiences. The data reviewed here support the perspective that neurons in multiple hippocampal subregions constitute an important neural substrate linking the external context, the internal context, and mnemonic and cognitive information to control both appetitive and ingestive behavior. Feeding behavior is heavily influenced by hippocampal-dependent mnemonic functions, including episodic meal-related memories and conditional learned associations between food-related stimuli and postingestive consequences. These mnemonic processes are undoubtedly influenced by both external and internal factors relating to food availability, location, and physiological energy status. The afferent and efferent neuroanatomical connectivity of the subregions of the hippocampus is reviewed with regard to the integration of visuospatial and olfactory sensory information (the external context) with endocrine and gastrointestinal interoceptive stimuli (the internal context). Also discussed are recent findings demonstrating that peripherally derived endocrine signals act on receptors in hippocampal neurons to reduce (leptin, glucagon-like peptide-1) or increase (ghrelin) food intake and learned food reward-driven responding, thereby highlighting endocrine and neuropeptidergic signaling in hippocampal neurons as a novel substrate of importance in the higher-order regulation of feeding behavior.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0006-3223
1873-2402
1873-2402
DOI:10.1016/j.biopsych.2015.09.011