Immunosenescence and human vaccine immune responses

The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Immunity & ageing Jg. 16; H. 1; S. 25 - 16
Hauptverfasser: Crooke, Stephen N., Ovsyannikova, Inna G., Poland, Gregory A., Kennedy, Richard B.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 13.09.2019
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Adaptive immunity
Aging
Aging (Biology)
Antibodies
B cell
B cells
Biomedical and Life Sciences
Biomedicine
Clinical Nutrition
Clinical outcomes
Elderly
Geriatrics/Gerontology
Gerontology
Health aspects
Immune response
Immune system
Immunology
Immunosenescence
Immunotherapy
Lymphocytes
Lymphocytes B
Medical research
Older people
Pathogenic microorganisms
Pathogens
Physiological aspects
Public Health
Review
T cell
T cells
Vaccination
Vaccine development
Vaccines
United States
B cell
Immune response
Vaccination
T cell
Aging
Immunosenescence
Adaptive immunity
ISSN:1742-4933, 1742-4933
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinated individuals, our understanding of the mechanisms governing the onset of immunosenescence and its effects on adaptive immunity remains incomplete. Age-dependent differences in T and B lymphocyte populations and functions have been well-defined, yet studies that demonstrate direct associations between immune cell function and clinical outcomes in older individuals are lacking. Despite these knowledge gaps, research has progressed in the development of vaccine and adjuvant formulations tailored for older adults in order to boost protective immunity and overcome immunosenescence. In this review, we will discuss the development of vaccines for older adults in light of our current understanding—or lack thereof—of the aging immune system. We highlight the functional changes that are known to occur in the adaptive immune system with age, followed by a discussion of current, clinically relevant pathogens that disproportionately affect older adults and are the central focus of vaccine research efforts for the aging population. We conclude with an outlook on personalized vaccine development for older adults and areas in need of further study in order to improve our fundamental understanding of adaptive immunosenescence.
AbstractList Abstract The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinated individuals, our understanding of the mechanisms governing the onset of immunosenescence and its effects on adaptive immunity remains incomplete. Age-dependent differences in T and B lymphocyte populations and functions have been well-defined, yet studies that demonstrate direct associations between immune cell function and clinical outcomes in older individuals are lacking. Despite these knowledge gaps, research has progressed in the development of vaccine and adjuvant formulations tailored for older adults in order to boost protective immunity and overcome immunosenescence. In this review, we will discuss the development of vaccines for older adults in light of our current understanding—or lack thereof—of the aging immune system. We highlight the functional changes that are known to occur in the adaptive immune system with age, followed by a discussion of current, clinically relevant pathogens that disproportionately affect older adults and are the central focus of vaccine research efforts for the aging population. We conclude with an outlook on personalized vaccine development for older adults and areas in need of further study in order to improve our fundamental understanding of adaptive immunosenescence.
The age-related dysregulation and decline of the immune system--collectively termed "immunosenescence"--has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinated individuals, our understanding of the mechanisms governing the onset of immunosenescence and its effects on adaptive immunity remains incomplete. Age-dependent differences in T and B lymphocyte populations and functions have been well-defined, yet studies that demonstrate direct associations between immune cell function and clinical outcomes in older individuals are lacking. Despite these knowledge gaps, research has progressed in the development of vaccine and adjuvant formulations tailored for older adults in order to boost protective immunity and overcome immunosenescence. In this review, we will discuss the development of vaccines for older adults in light of our current understanding--or lack thereof--of the aging immune system. We highlight the functional changes that are known to occur in the adaptive immune system with age, followed by a discussion of current, clinically relevant pathogens that disproportionately affect older adults and are the central focus of vaccine research efforts for the aging population. We conclude with an outlook on personalized vaccine development for older adults and areas in need of further study in order to improve our fundamental understanding of adaptive immunosenescence. Keywords: Immunosenescence, Vaccination, Aging, Immune response, T cell, B cell, Adaptive immunity
The age-related dysregulation and decline of the immune system-collectively termed "immunosenescence"-has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinated individuals, our understanding of the mechanisms governing the onset of immunosenescence and its effects on adaptive immunity remains incomplete. Age-dependent differences in T and B lymphocyte populations and functions have been well-defined, yet studies that demonstrate direct associations between immune cell function and clinical outcomes in older individuals are lacking. Despite these knowledge gaps, research has progressed in the development of vaccine and adjuvant formulations tailored for older adults in order to boost protective immunity and overcome immunosenescence. In this review, we will discuss the development of vaccines for older adults in light of our current understanding-or lack thereof-of the aging immune system. We highlight the functional changes that are known to occur in the adaptive immune system with age, followed by a discussion of current, clinically relevant pathogens that disproportionately affect older adults and are the central focus of vaccine research efforts for the aging population. We conclude with an outlook on personalized vaccine development for older adults and areas in need of further study in order to improve our fundamental understanding of adaptive immunosenescence.The age-related dysregulation and decline of the immune system-collectively termed "immunosenescence"-has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinated individuals, our understanding of the mechanisms governing the onset of immunosenescence and its effects on adaptive immunity remains incomplete. Age-dependent differences in T and B lymphocyte populations and functions have been well-defined, yet studies that demonstrate direct associations between immune cell function and clinical outcomes in older individuals are lacking. Despite these knowledge gaps, research has progressed in the development of vaccine and adjuvant formulations tailored for older adults in order to boost protective immunity and overcome immunosenescence. In this review, we will discuss the development of vaccines for older adults in light of our current understanding-or lack thereof-of the aging immune system. We highlight the functional changes that are known to occur in the adaptive immune system with age, followed by a discussion of current, clinically relevant pathogens that disproportionately affect older adults and are the central focus of vaccine research efforts for the aging population. We conclude with an outlook on personalized vaccine development for older adults and areas in need of further study in order to improve our fundamental understanding of adaptive immunosenescence.
The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinated individuals, our understanding of the mechanisms governing the onset of immunosenescence and its effects on adaptive immunity remains incomplete. Age-dependent differences in T and B lymphocyte populations and functions have been well-defined, yet studies that demonstrate direct associations between immune cell function and clinical outcomes in older individuals are lacking. Despite these knowledge gaps, research has progressed in the development of vaccine and adjuvant formulations tailored for older adults in order to boost protective immunity and overcome immunosenescence. In this review, we will discuss the development of vaccines for older adults in light of our current understanding—or lack thereof—of the aging immune system. We highlight the functional changes that are known to occur in the adaptive immune system with age, followed by a discussion of current, clinically relevant pathogens that disproportionately affect older adults and are the central focus of vaccine research efforts for the aging population. We conclude with an outlook on personalized vaccine development for older adults and areas in need of further study in order to improve our fundamental understanding of adaptive immunosenescence.
ArticleNumber 25
Audience Academic
Author Ovsyannikova, Inna G.
Kennedy, Richard B.
Crooke, Stephen N.
Poland, Gregory A.
Author_xml – sequence: 1
  givenname: Stephen N.
  surname: Crooke
  fullname: Crooke, Stephen N.
  organization: Mayo Clinic Vaccine Research Group, Mayo Clinic
– sequence: 2
  givenname: Inna G.
  surname: Ovsyannikova
  fullname: Ovsyannikova, Inna G.
  organization: Mayo Clinic Vaccine Research Group, Mayo Clinic
– sequence: 3
  givenname: Gregory A.
  surname: Poland
  fullname: Poland, Gregory A.
  organization: Mayo Clinic Vaccine Research Group, Mayo Clinic
– sequence: 4
  givenname: Richard B.
  surname: Kennedy
  fullname: Kennedy, Richard B.
  email: kennedy.rick@mayo.edu
  organization: Mayo Clinic Vaccine Research Group, Mayo Clinic
BookMark eNp9Uk1r3DAQFSWlSbb9Ab0ZeunFqb4sW5dCCE27EMilPQtZHm-02NJWsgP99x3HoemGNgghMXrvzbzRnJOTEAMQ8p7RC8Ya9SkzrmtdUrZsJUv9ipyxWvJSaiFO_rqfkvOc95QKqZV8Q04Fq3jDGnpGxHYc5xAzBMgOgoPChq64m0cbinvrnA9Q-AUCRYJ8iCFDfkte93bI8O7x3JAf11--X30rb26_bq8ub0qnpJrKzuoe80AFVSU721PKm4b1NQhqWSUoKCWd0q2WygkngWFcUdlUFdNYWyc2ZLvqdtHuzSH50aZfJlpvHgIx7YxNk3cDmJ620lrpuqYGCVK1PectU0rwTjWUNaj1edU6zO0IHVqdkh2ORI9fgr8zu3hvVC0FkzUKfHwUSPHnDHkyo8eODYMNEOdsONeCcimw2xvy4Rl0H-cUsFULimNR-A9PqJ1FAz70EfO6RdRcKop_WivOEHXxDxSuDkbvcBx6j_EjAlsJLsWcE_R_PDJqlqkx69QYJJhlasxSSv2M4_xkJx-XVvjhRSZfmRmzhB2kJ6v_J_0G5HXTew
CitedBy_id crossref_primary_10_1016_j_msard_2024_105547
crossref_primary_10_2196_59762
crossref_primary_10_3389_fimmu_2022_1021500
crossref_primary_10_2174_0113892010308600240709052539
crossref_primary_10_3389_fimmu_2021_778679
crossref_primary_10_1212_WNL_0000000000210281
crossref_primary_10_1111_all_15977
crossref_primary_10_1038_s41467_020_19967_4
crossref_primary_10_1080_21645515_2024_2317439
crossref_primary_10_3390_vaccines9070781
crossref_primary_10_3390_diagnostics12030666
crossref_primary_10_1186_s12879_024_10385_1
crossref_primary_10_1007_s11606_023_08254_9
crossref_primary_10_1080_14760584_2024_2428243
crossref_primary_10_1007_s40121_022_00711_y
crossref_primary_10_1002_wsbm_1510
crossref_primary_10_1111_cei_13593
crossref_primary_10_1080_19490976_2024_2359691
crossref_primary_10_1111_acel_14007
crossref_primary_10_1177_1060028020935645
crossref_primary_10_3389_fimmu_2021_681449
crossref_primary_10_3389_fcell_2021_725606
crossref_primary_10_1038_s41577_020_00479_7
crossref_primary_10_1093_cid_ciab1005
crossref_primary_10_1186_s12979_024_00479_4
crossref_primary_10_3390_vaccines9060609
crossref_primary_10_3390_vaccines8010034
crossref_primary_10_3389_fimmu_2023_1146704
crossref_primary_10_1371_journal_pone_0254421
crossref_primary_10_1093_cid_ciae180
crossref_primary_10_1002_jcla_25114
crossref_primary_10_1016_j_arr_2021_101455
crossref_primary_10_1016_j_exger_2021_111599
crossref_primary_10_1016_j_exger_2021_111471
crossref_primary_10_1016_j_jgo_2022_07_005
crossref_primary_10_3390_vaccines9121435
crossref_primary_10_1177_13524585251318513
crossref_primary_10_1093_jacamr_dlab052
crossref_primary_10_3389_fpubh_2023_1067218
crossref_primary_10_1186_s12979_025_00512_0
crossref_primary_10_3390_cells11223641
crossref_primary_10_3390_vaccines13010067
crossref_primary_10_3389_fchem_2020_589959
crossref_primary_10_1186_s12913_022_08586_y
crossref_primary_10_3390_vaccines11061118
crossref_primary_10_3934_publichealth_2021030
crossref_primary_10_1038_s41467_022_30617_9
crossref_primary_10_1136_bmjopen_2022_063919
crossref_primary_10_1111_tid_14051
crossref_primary_10_1155_2022_5743106
crossref_primary_10_3390_cells12242819
crossref_primary_10_1002_j_2040_4603_2022_tb00221_x
crossref_primary_10_1177_1073858420987224
crossref_primary_10_1038_s41467_022_34051_9
crossref_primary_10_1186_s12889_021_10427_2
crossref_primary_10_3390_vaccines9121431
crossref_primary_10_1186_s12979_021_00237_w
crossref_primary_10_1084_jem_20202756
crossref_primary_10_4103_PMRR_PMRR_13_24
crossref_primary_10_1016_j_bbadis_2022_166393
crossref_primary_10_1080_21645515_2025_2514357
crossref_primary_10_3389_fimmu_2023_1280144
crossref_primary_10_1016_j_imlet_2024_106940
crossref_primary_10_1038_s41598_021_91445_3
crossref_primary_10_1186_s13020_024_01043_4
crossref_primary_10_1038_s41573_021_00283_5
crossref_primary_10_1146_annurev_cellbio_011620_034148
crossref_primary_10_1002_hem3_125
crossref_primary_10_1016_j_bbih_2021_100381
crossref_primary_10_3389_fmed_2023_1215167
crossref_primary_10_1016_j_msard_2023_104967
crossref_primary_10_1371_journal_pntd_0013028
crossref_primary_10_1097_MOT_0000000000000760
crossref_primary_10_1136_bmjresp_2020_000872
crossref_primary_10_3389_fimmu_2023_1259725
crossref_primary_10_1093_infdis_jiac189
crossref_primary_10_3390_v13071400
crossref_primary_10_1093_nutrit_nuaf027
crossref_primary_10_31083_j_fbl2809225
crossref_primary_10_1016_j_vaccine_2025_127090
crossref_primary_10_1038_s41541_021_00421_5
crossref_primary_10_1186_s12979_023_00334_y
crossref_primary_10_1016_j_exger_2021_111497
crossref_primary_10_1136_bmjebm_2020_111549
crossref_primary_10_3390_jcm12062281
crossref_primary_10_1097_QAD_0000000000003585
crossref_primary_10_1126_sciimmunol_abf6136
crossref_primary_10_3390_vaccines12030333
crossref_primary_10_1093_cid_ciab447
crossref_primary_10_3390_ijms22083990
crossref_primary_10_1172_JCI175378
crossref_primary_10_12968_bjon_2021_30_6_382
crossref_primary_10_1016_j_jgo_2021_06_002
crossref_primary_10_3390_microorganisms12061213
crossref_primary_10_3390_vaccines13060621
crossref_primary_10_1080_14760584_2023_2256394
crossref_primary_10_1038_s41385_021_00404_8
crossref_primary_10_33262_ap_v6i2_521
crossref_primary_10_3389_fimmu_2025_1501275
crossref_primary_10_1016_j_vetimm_2024_110816
crossref_primary_10_1093_infdis_jiaf148
crossref_primary_10_3389_fphys_2020_571416
crossref_primary_10_3390_vaccines13040340
crossref_primary_10_1136_bmj_n188
crossref_primary_10_3389_fimmu_2022_872652
crossref_primary_10_1093_ckj_sfad180
crossref_primary_10_3390_vaccines9030202
crossref_primary_10_1080_07853890_2020_1811888
crossref_primary_10_3389_fimmu_2022_918611
crossref_primary_10_3389_fimmu_2020_583019
crossref_primary_10_3390_vaccines10050819
crossref_primary_10_3389_fimmu_2021_779212
crossref_primary_10_7759_cureus_33962
crossref_primary_10_1186_s12879_024_09572_x
crossref_primary_10_1016_j_virol_2021_12_003
crossref_primary_10_1186_s12979_022_00266_z
crossref_primary_10_1111_jgs_17153
crossref_primary_10_3390_vaccines12040353
crossref_primary_10_1177_0300060520913149
crossref_primary_10_25259_IJDVL_819_2021
crossref_primary_10_3389_fimmu_2022_940705
crossref_primary_10_1016_j_mayocp_2021_06_023
crossref_primary_10_1093_cei_uxad015
crossref_primary_10_1007_s11357_024_01451_2
crossref_primary_10_3389_fmed_2021_675573
crossref_primary_10_1016_j_arr_2022_101634
crossref_primary_10_3390_antibiotics12091429
crossref_primary_10_1097_CM9_0000000000003410
crossref_primary_10_1093_oxfimm_iqab007
crossref_primary_10_1097_QAI_0000000000002435
crossref_primary_10_3389_fcimb_2022_1072703
crossref_primary_10_1371_journal_pone_0331971
crossref_primary_10_1073_pnas_2308511120
crossref_primary_10_1016_j_vaccine_2024_126591
crossref_primary_10_1177_2050313X221077737
crossref_primary_10_1093_advances_nmaa125
crossref_primary_10_3390_vaccines9091013
crossref_primary_10_1186_s12979_022_00314_8
crossref_primary_10_3390_vaccines11071196
crossref_primary_10_3389_fimmu_2020_01755
crossref_primary_10_3390_vaccines12050479
crossref_primary_10_3389_fpubh_2022_903376
crossref_primary_10_1016_j_buildenv_2024_112355
crossref_primary_10_3389_fimmu_2025_1584876
crossref_primary_10_3390_ijms22052668
crossref_primary_10_1038_s41541_025_01255_1
crossref_primary_10_1128_spectrum_01155_23
crossref_primary_10_1186_s12979_020_00180_2
crossref_primary_10_3390_ijms21010055
crossref_primary_10_3390_ijms241311029
crossref_primary_10_1007_s40472_023_00405_5
crossref_primary_10_1016_j_healun_2021_04_017
crossref_primary_10_1183_23120541_00557_2020
crossref_primary_10_1186_s12979_024_00476_7
crossref_primary_10_7554_eLife_95880_4
crossref_primary_10_1371_journal_pntd_0012411
crossref_primary_10_1155_2022_3860896
crossref_primary_10_3390_v14020207
crossref_primary_10_1016_j_jinf_2024_106319
crossref_primary_10_1093_labmed_lmac047
crossref_primary_10_3389_fimmu_2023_1160664
crossref_primary_10_1038_s41435_021_00126_8
crossref_primary_10_3390_biom14101217
crossref_primary_10_1111_febs_15613
crossref_primary_10_1186_s12979_024_00430_7
crossref_primary_10_1111_acel_13341
crossref_primary_10_3389_fimmu_2021_784145
crossref_primary_10_1016_j_ijid_2022_10_041
crossref_primary_10_1016_j_intimp_2021_107761
crossref_primary_10_3390_vaccines11050933
crossref_primary_10_1016_j_mayocp_2020_11_024
crossref_primary_10_1007_s40266_024_01118_9
crossref_primary_10_1016_j_heliyon_2023_e15241
crossref_primary_10_3390_vaccines9060572
crossref_primary_10_3390_vaccines8020225
crossref_primary_10_1016_j_vaccine_2025_127029
crossref_primary_10_3389_fimmu_2022_864674
crossref_primary_10_3390_vaccines8040636
crossref_primary_10_3390_ijms23179797
crossref_primary_10_3390_ijms24032700
crossref_primary_10_1080_14760584_2025_2502031
crossref_primary_10_1080_21645515_2024_2377904
crossref_primary_10_2147_CIA_S382311
crossref_primary_10_3389_fimmu_2023_1131051
crossref_primary_10_1093_ibd_izaf170
crossref_primary_10_1080_22221751_2022_2088406
crossref_primary_10_1186_s12979_022_00290_z
crossref_primary_10_1186_s12979_024_00480_x
crossref_primary_10_1016_j_jgo_2022_05_002
crossref_primary_10_3389_fcell_2021_677944
crossref_primary_10_3390_vaccines10010058
crossref_primary_10_3389_fimmu_2024_1421062
crossref_primary_10_3390_vaccines9030245
crossref_primary_10_1186_s12979_021_00219_y
crossref_primary_10_1186_s12967_020_02363_3
crossref_primary_10_1016_j_vaccine_2022_04_043
crossref_primary_10_3389_fimmu_2021_676932
crossref_primary_10_1038_s43587_022_00343_4
crossref_primary_10_1097_TP_0000000000003922
crossref_primary_10_1093_cid_ciab078
crossref_primary_10_1182_bloodadvances_2022009054
crossref_primary_10_1177_10815589241249993
crossref_primary_10_1055_a_2586_3974
crossref_primary_10_1016_j_vaccine_2025_127393
crossref_primary_10_1016_S0140_6736_25_00372_1
crossref_primary_10_1111_jgs_17198
crossref_primary_10_7554_eLife_95880
crossref_primary_10_1016_j_ijbiomac_2024_134012
crossref_primary_10_1016_j_clnu_2023_01_001
crossref_primary_10_1186_s12979_020_00194_w
crossref_primary_10_1016_j_jgo_2021_03_003
crossref_primary_10_1080_14760584_2022_2021075
crossref_primary_10_1155_2020_8624963
crossref_primary_10_1186_s41100_022_00397_5
crossref_primary_10_1002_jppr_1891
crossref_primary_10_3390_microorganisms12040775
crossref_primary_10_1038_s41541_023_00757_0
crossref_primary_10_3390_vaccines9111232
crossref_primary_10_3233_JAD_200413
crossref_primary_10_1016_j_aprim_2022_102462
crossref_primary_10_1186_s40359_025_03325_4
crossref_primary_10_3390_vaccines10050641
crossref_primary_10_1007_s00284_023_03367_0
crossref_primary_10_1016_j_vaccine_2024_126675
crossref_primary_10_3389_fcimb_2023_1229098
crossref_primary_10_3389_fcimb_2024_1381776
crossref_primary_10_1007_s12016_021_08909_7
crossref_primary_10_1016_j_vaccine_2021_03_066
crossref_primary_10_1038_s41541_025_01196_9
crossref_primary_10_3390_vaccines9121392
crossref_primary_10_4049_jimmunol_2001287
crossref_primary_10_1016_j_trim_2023_101851
crossref_primary_10_3389_fimmu_2021_748397
crossref_primary_10_1016_j_cgh_2022_01_012
crossref_primary_10_1016_j_heliyon_2023_e18614
crossref_primary_10_1002_hsr2_71119
crossref_primary_10_1080_08830185_2021_1925267
crossref_primary_10_1080_21645515_2024_2323853
crossref_primary_10_3389_fimmu_2021_621440
crossref_primary_10_1097_ICO_0000000000003556
crossref_primary_10_3390_biom14030262
crossref_primary_10_1155_2020_5459793
crossref_primary_10_3390_ijms242115584
crossref_primary_10_3390_vaccines9111340
crossref_primary_10_1016_j_maturitas_2020_10_002
crossref_primary_10_3389_fimmu_2023_1183727
crossref_primary_10_1186_s12979_020_00179_9
crossref_primary_10_3389_ti_2023_11751
crossref_primary_10_2340_actadv_v104_40009
crossref_primary_10_1097_ALN_0000000000003303
crossref_primary_10_1080_19390211_2025_2539876
crossref_primary_10_1038_s43856_023_00277_x
crossref_primary_10_1016_j_imu_2021_100809
crossref_primary_10_3389_fimmu_2022_949928
crossref_primary_10_3390_v14081785
crossref_primary_10_3390_nu14010228
crossref_primary_10_1093_jtm_taab126
crossref_primary_10_1080_21645515_2025_2507912
crossref_primary_10_1016_j_jiph_2025_102700
crossref_primary_10_4103_ijcm_ijcm_741_24
crossref_primary_10_1186_s12877_022_02884_0
crossref_primary_10_3390_v15010156
crossref_primary_10_3390_vaccines10091527
crossref_primary_10_1016_j_arr_2024_102575
crossref_primary_10_3390_vaccines11020382
crossref_primary_10_1186_s12879_023_08158_3
crossref_primary_10_3390_vaccines11020383
crossref_primary_10_1038_s41467_022_32312_1
crossref_primary_10_1038_s41598_023_35328_9
crossref_primary_10_1073_pnas_2118895119
crossref_primary_10_1016_j_jaci_2020_03_017
crossref_primary_10_3390_tropicalmed6030153
crossref_primary_10_52711_0974_360X_2025_00327
crossref_primary_10_1038_s41467_024_54757_2
crossref_primary_10_1007_s40520_021_01987_9
crossref_primary_10_1186_s12979_021_00244_x
crossref_primary_10_1177_20552173231198588
crossref_primary_10_3390_vaccines11061089
crossref_primary_10_3201_eid2708_211145
crossref_primary_10_3390_jpm12111817
crossref_primary_10_1159_000509216
crossref_primary_10_3389_fimmu_2020_00717
crossref_primary_10_1051_bioconf_202410004010
crossref_primary_10_3389_fimmu_2020_616949
crossref_primary_10_3389_fimmu_2022_812126
crossref_primary_10_1002_cti2_1463
crossref_primary_10_1002_eji_202149465
crossref_primary_10_4049_jimmunol_2200369
crossref_primary_10_1038_s41541_021_00422_4
crossref_primary_10_1111_jdv_18184
crossref_primary_10_1016_j_cger_2022_04_002
crossref_primary_10_1016_j_vaccine_2020_06_021
crossref_primary_10_1080_17476348_2024_2422961
crossref_primary_10_1080_1744666X_2021_1886924
crossref_primary_10_3390_microorganisms11020519
crossref_primary_10_1007_s40120_025_00767_1
crossref_primary_10_3389_fpubh_2020_574198
crossref_primary_10_1093_cid_ciab381
crossref_primary_10_1186_s12979_023_00344_w
crossref_primary_10_3389_fimmu_2024_1383476
crossref_primary_10_1038_s41598_024_58811_3
crossref_primary_10_3389_fimmu_2023_1190339
crossref_primary_10_3390_biomedicines11113002
crossref_primary_10_1038_s41467_025_62800_z
crossref_primary_10_1016_j_transci_2020_102936
crossref_primary_10_3390_epidemiologia4040035
crossref_primary_10_1016_j_heliyon_2023_e15821
crossref_primary_10_1016_j_vaccine_2021_07_023
crossref_primary_10_1186_s12885_022_09860_2
crossref_primary_10_1016_j_idc_2022_11_007
crossref_primary_10_1177_25151355241310601
crossref_primary_10_1016_j_compbiomed_2024_109069
crossref_primary_10_1016_j_vaccine_2020_11_002
crossref_primary_10_1016_j_vaccine_2024_04_059
crossref_primary_10_1097_TP_0000000000004715
crossref_primary_10_1016_j_vaccine_2022_05_059
crossref_primary_10_1134_S2079057021010458
crossref_primary_10_3389_fimmu_2022_817597
crossref_primary_10_3389_fimmu_2023_1061255
crossref_primary_10_3390_vaccines12060566
crossref_primary_10_1016_j_idc_2022_11_002
crossref_primary_10_1016_j_banm_2023_12_010
crossref_primary_10_1093_infdis_jiad474
crossref_primary_10_1016_j_ijid_2021_09_045
crossref_primary_10_3390_pathophysiology30040043
crossref_primary_10_7759_cureus_24277
crossref_primary_10_2196_48255
crossref_primary_10_3390_vaccines12111289
crossref_primary_10_3390_medsci13030100
Cites_doi 10.1046/j.1365-2249.1996.d01-790.x
10.1016/j.vaccine.2016.06.034
10.3947/ic.2013.45.2.159
10.1371/journal.pone.0169368
10.1371/journal.pone.0185666
10.1086/517376
10.1093/cid/ciq207
10.1093/infdis/jis240
10.1016/j.vaccine.2016.02.024
10.1056/NEJMoa051016
10.1016/j.maturitas.2015.05.004
10.1126/scitranslmed.3004794
10.1093/cid/ciu918
10.4049/jimmunol.1500046
10.1111/j.1532-5415.2010.03021.x
10.1016/S2213-2600(13)70165-6
10.3389/fimmu.2018.02309
10.1093/infdis/jiy016
10.1016/j.jacc.2018.02.013
10.1084/jem.168.3.1163
10.1016/j.lfs.2015.10.025
10.1378/chest.10-0738
10.3389/fimmu.2018.00395
10.1016/j.vaccine.2015.09.073
10.1128/JVI.75.24.12182-12187.2001
10.1016/j.exger.2017.07.002
10.1002/cyto.b.10007
10.1056/NEJMoa1501184
10.4049/jimmunol.179.2.918
10.1101/cshperspect.a028894
10.4049/jimmunol.1500319
10.1146/annurev-immunol-032712-100010
10.2174/157339511794474181
10.1016/j.smim.2018.05.001
10.1186/s12979-016-0079-7
10.1016/j.exger.2014.01.010
10.1038/srep30842
10.3389/fimmu.2016.00450
10.1073/pnas.1402981111
10.1016/j.vaccine.2010.12.121
10.3389/fimmu.2016.00041
10.1080/21645515.2018.1442162
10.1016/S0889-8561(02)00078-4
10.4049/jimmunol.172.4.2155
10.1080/14760584.2019.1575208
10.1007/s10522-008-9150-x
10.1002/eji.201444878
10.3389/fimmu.2018.00082
10.4049/jimmunol.170.4.1754
10.3390/pathogens2020364
10.1038/nri778
10.1016/j.vaccine.2005.08.105
10.4049/jimmunol.1301721
10.1186/1741-7015-8-37
10.1016/j.celrep.2018.05.057
10.1371/journal.ppat.1005891
10.1093/infdis/jiy095
10.4049/jimmunol.1302509
10.1016/j.vaccine.2016.03.109
10.1073/pnas.0705905104
10.4049/jimmunol.0901022
10.1111/j.1474-9726.2012.00867.x
10.3389/fimmu.2017.00706
10.1172/JCI97377
10.1111/j.1474-9726.2008.00443.x
10.1093/infdis/jix503
10.1007/82_2010_31
10.1590/0001-3765201720160487
10.1038/ni.3123
10.1038/s41598-018-28111-8
10.1111/j.1365-2567.2004.02006.x
10.4049/jimmunol.0902063
10.1093/intimm/8.4.509
10.1164/rccm.201412-2256OC
10.1038/srep25051
10.1016/j.jinf.2017.09.010
10.3389/fimmu.2018.01553
10.1080/21645515.2017.1329069
10.1093/gerona/glu171
10.3389/fmicb.2016.02111
10.4049/jimmunol.179.9.6153
10.1111/acel.12430
10.1016/j.vaccine.2008.07.071
10.4049/jimmunol.172.12.7432
10.1038/nm.2963
10.1371/journal.ppat.1000159
10.1016/j.coi.2010.05.003
10.1155/2014/436438
10.1016/j.arr.2017.07.002
10.1073/pnas.1000834107
10.1016/j.jdiacomp.2019.03.007
10.1007/s12026-013-8440-9
10.1172/JCI83024
10.1016/j.vaccine.2016.11.054
10.1111/acel.12384
10.1385/IR:22:2-3:253
10.1016/j.immuni.2006.10.011
10.1186/s12879-017-2897-4
10.1111/j.1600-065X.2010.00937.x
10.3389/fimmu.2017.00896
10.1093/infdis/jiw047
10.1056/NEJMoa043951
10.1093/infdis/jiv281
10.1007/s40471-018-0136-1
10.1016/j.vaccine.2011.03.081
10.1371/journal.pone.0152034
10.1371/journal.ppat.1002849
10.4049/jimmunol.1500520
10.1128/CMR.00052-13
10.1023/A:1024580531705
10.1007/s00430-019-00602-z
10.4049/jimmunol.176.4.2645
10.1080/14760584.2016.1254044
10.1038/ni.2018
10.4049/jimmunol.1301453
10.1073/pnas.1107594108
10.4049/jimmunol.178.11.6912
10.1073/pnas.1116110108
10.1016/j.vaccine.2012.11.041
10.1016/j.exger.2018.01.005
10.1128/JVI.00269-18
10.1016/j.vaccine.2015.05.102
10.1177/1060028018758431
10.1172/JCI57834
10.2217/ahe.09.69
10.1016/j.vaccine.2017.07.062
10.4049/jimmunol.171.11.5975
10.1056/NEJMoa1603800
10.2147/CIA.S51152
10.1371/journal.ppat.1002920
10.1093/infdis/jir048
10.1007/978-3-642-38919-1_18
10.1086/421524
10.1196/annals.1386.013
10.3389/fimmu.2012.00193
10.1086/429695
10.1084/jem.20071140
10.1016/j.coi.2013.07.006
10.1111/cei.12700
10.1542/peds.2012-3303
10.1038/s41590-017-0006-x
10.1089/rej.2006.9.149
10.1007/s00109-009-0579-4
10.1371/journal.pone.0034145
10.1016/j.vaccine.2015.03.072
10.1016/j.exger.2014.01.004
10.1093/cid/ciy991
10.4049/jimmunol.168.11.5893
10.1084/jem.20021765
10.4049/jimmunol.1002837
10.1016/j.vaccine.2015.05.098
10.1089/rej.2006.9.117
10.1128/CVI.00580-12
10.1164/rccm.200210-1148OC
10.1006/clim.1998.4638
10.1371/journal.pone.0066312
10.1111/j.1749-6632.2012.06673.x
10.1128/CVI.00110-08
10.1586/14760584.2014.905744
10.1093/infdis/jiy382
10.1038/nri2508
10.1016/S0047-6374(00)00240-2
10.1371/journal.ppat.1005027
10.1016/j.mad.2009.08.003
10.1016/j.vaccine.2016.12.011
10.1016/j.arr.2010.12.002
10.1038/ni923
10.1016/j.vaccine.2018.01.045
10.2165/00002512-200522070-00004
10.1080/14760584.2016.1213632
10.4049/jimmunol.1302064
10.1016/j.clim.2018.01.011
10.1111/j.1532-5415.2012.04048.x
10.4049/jimmunol.180.8.5283
10.1186/1742-4933-2-10
10.1128/IAI.00768-10
10.1056/NEJMoa1408544
10.1097/SMJ.0b013e318181d5b5
10.1002/14651858.CD000422.pub3
10.1371/journal.pone.0182498
10.1007/s11357-010-9191-3
10.1172/JCI121484
10.1016/j.immuni.2012.02.006
10.1016/j.jim.2014.10.010
10.1371/journal.pone.0185843
10.1016/j.humimm.2009.07.005
10.4049/jimmunol.172.6.3437
10.1016/j.coi.2017.06.005
10.1016/S1473-3099(11)70295-X
10.3201/eid2406.172114
10.1038/s41598-017-17735-x
10.1016/j.vaccine.2011.09.061
10.1164/ajrccm.153.3.8630547
10.1093/cid/cit471
10.1186/s12931-018-0784-1
10.1189/jlb.3RI0716-335R
10.1126/sciimmunol.aam9304
10.1186/1742-4933-7-14
10.4110/in.2015.15.4.186
10.4049/jimmunol.173.1.673
10.4049/jimmunol.1401174
10.3389/fimmu.2013.00107
ContentType Journal Article
Copyright The Author(s). 2019
COPYRIGHT 2019 BioMed Central Ltd.
2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s). 2019
– notice: COPYRIGHT 2019 BioMed Central Ltd.
– notice: 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
3V.
7T5
7X7
7XB
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
H94
K9.
M0S
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1186/s12979-019-0164-9
DatabaseName Springer Nature OA Free Journals
CrossRef
ProQuest Central (Corporate)
Immunology Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
ProQuest Databases
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals (DOAJ)
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

MEDLINE - Academic


CrossRef
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: PIMPY
  name: Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Public Health
Biology
Social Welfare & Social Work
EISSN 1742-4933
EndPage 16
ExternalDocumentID oai_doaj_org_article_f0b4aa4cd87e4e46bf22b16632d68018
PMC6743147
A600197621
10_1186_s12979_019_0164_9
GeographicLocations United States
GeographicLocations_xml – name: United States
GrantInformation_xml – fundername: National Institute of Allergy and Infectious Diseases
  grantid: AI089859; AI132348
  funderid: http://dx.doi.org/10.13039/100000060
– fundername: ;
  grantid: AI089859; AI132348
GroupedDBID ---
0R~
29I
2WC
53G
5GY
5VS
7X7
8FI
8FJ
AAFWJ
AAJSJ
AASML
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AHBYD
AHMBA
AHYZX
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
E3Z
EBD
EBLON
EBS
EJD
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HMCUK
HYE
IAO
IHR
ITC
KQ8
M48
M~E
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PUEGO
RBZ
RNS
ROL
RPM
RSV
SBL
SOJ
TR2
TUS
UKHRP
WOQ
WOW
XSB
~8M
AAYXX
AFFHD
CITATION
3V.
7T5
7XB
8FK
AZQEC
DWQXO
H94
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c646t-da9f152e5e554daf002881f7e30a1530e664c69b946c3c4e130a60485519180d3
IEDL.DBID BENPR
ISICitedReferencesCount 371
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000485862300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1742-4933
IngestDate Tue Oct 14 19:05:54 EDT 2025
Tue Nov 04 01:52:00 EST 2025
Sun Nov 09 12:35:22 EST 2025
Wed Oct 15 14:30:52 EDT 2025
Tue Nov 11 10:19:00 EST 2025
Tue Nov 04 17:27:19 EST 2025
Sat Nov 29 03:39:04 EST 2025
Tue Nov 18 21:40:40 EST 2025
Sat Sep 06 07:19:20 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords B cell
Immune response
Vaccination
T cell
Aging
Immunosenescence
Adaptive immunity
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c646t-da9f152e5e554daf002881f7e30a1530e664c69b946c3c4e130a60485519180d3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
OpenAccessLink https://www.proquest.com/docview/2292632349?pq-origsite=%requestingapplication%
PMID 31528180
PQID 2292632349
PQPubID 54869
PageCount 16
ParticipantIDs doaj_primary_oai_doaj_org_article_f0b4aa4cd87e4e46bf22b16632d68018
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6743147
proquest_miscellaneous_2293024393
proquest_journals_2292632349
gale_infotracmisc_A600197621
gale_infotracacademiconefile_A600197621
crossref_primary_10_1186_s12979_019_0164_9
crossref_citationtrail_10_1186_s12979_019_0164_9
springer_journals_10_1186_s12979_019_0164_9
PublicationCentury 2000
PublicationDate 2019-09-13
PublicationDateYYYYMMDD 2019-09-13
PublicationDate_xml – month: 09
  year: 2019
  text: 2019-09-13
  day: 13
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Immunity & ageing
PublicationTitleAbbrev Immun Ageing
PublicationYear 2019
Publisher BioMed Central
BioMed Central Ltd
Springer Nature B.V
BMC
Publisher_xml – name: BioMed Central
– name: BioMed Central Ltd
– name: Springer Nature B.V
– name: BMC
References JA Belser (164_CR189) 2018; 24
T Fulop (164_CR1) 2016; 68
EA Voigt (164_CR206) 2018; 8
WW Pang (164_CR87) 2011; 108
BC Chiu (164_CR51) 2013; 191
JJ Bleesing (164_CR186) 2003; 51
M Bulati (164_CR82) 2011; 10
Q Yu (164_CR42) 2003; 197
CA Siegrist (164_CR20) 2009; 9
J Kim (164_CR56) 2015; 15
A Sridharan (164_CR75) 2011; 33
Y Deng (164_CR126) 2004; 172
F Qian (164_CR76) 2011; 203
I Beerman (164_CR86) 2010; 107
AM Didierlaurent (164_CR180) 2017; 16
RJ Looney (164_CR55) 1999; 90
RB Kennedy (164_CR201) 2014; 13
BF Haynes (164_CR41) 2000; 22
M Bajenoff (164_CR113) 2006; 25
A Bektas (164_CR67) 2017; 102
M Saurwein-Teissl (164_CR62) 2002; 168
HL Thompson (164_CR26) 2017; 8
J Nikolich-Zugich (164_CR4) 2018; 19
B Simell (164_CR160) 2011; 29
R Malley (164_CR156) 2010; 88
Y Xiao (164_CR185) 2004; 172
CJ Henry (164_CR84) 2015; 125
P Schmid (164_CR161) 2011; 29
Y Fukuyama (164_CR159) 2011; 186
PJ Fink (164_CR43) 2013; 31
S Ferrando-Martinez (164_CR198) 2015; 70
D Frasca (164_CR96) 2018; 107
G Li (164_CR79) 2012; 11
Bradley Ackerson (164_CR134) 2018; 69
Myron J. Levin (164_CR174) 2018; 128
DM Musher (164_CR167) 2011; 52
I den Braber (164_CR44) 2012; 36
GJ de Bree (164_CR141) 2005; 191
G Colonna-Romano (164_CR88) 2009; 130
MJ Cannon (164_CR138) 1988; 168
MS Habibi (164_CR147) 2015; 191
AA Gershon (164_CR169) 2013; 26
SF James (164_CR177) 2018; 52
KH Chan (164_CR121) 2011; 18
J Dock (164_CR193) 2017; 12
GR Boss (164_CR36) 1981; 135
PC Wroe (164_CR7) 2012; 205
E Derhovanessian (164_CR58) 2013; 31
S D'Angelo (164_CR106) 2018; 9
YJ Lu (164_CR163) 2008; 4
S. P. H. van den Berg (164_CR59) 2019; 208
DE Zak (164_CR204) 2015; 33
A Agrawal (164_CR71) 2017; 8
AL Cunningham (164_CR182) 2018; 218
IH Haralambieva (164_CR205) 2016; 34
TF Tsai (164_CR130) 2013; 45
AR Falsey (164_CR132) 2005; 22
JM Richner (164_CR112) 2015; 11
MJ Bonten (164_CR153) 2015; 372
D Frasca (164_CR101) 2008; 180
G Colonna-Romano (164_CR90) 2006; 9
Takeshi Kawabe (164_CR53) 2017; 2
EM Lowery (164_CR37) 2013; 8
MA Moro-Garcia (164_CR63) 2013; 4
R Lambkin-Williams (164_CR192) 2018; 19
JL Scholz (164_CR6) 2013; 25
A Agrawal (164_CR77) 2007; 178
S Tahir (164_CR70) 2015; 194
AR Falsey (164_CR146) 1998; 177
KC Meyer (164_CR164) 1996; 153
S Park (164_CR17) 2011; 79
ML Metersky (164_CR168) 2010; 138
RB Fulton (164_CR119) 2009; 5
CH Ju (164_CR120) 2018; 193
A Iwasaki (164_CR31) 2015; 16
T Pilishvili (164_CR154) 2015; 33
J Olsson (164_CR195) 2000; 121
BS Bender (164_CR39) 2003; 23
IA Nunez (164_CR118) 2017; 12
HF Tseng (164_CR13) 2016; 213
DT O’Hagan (164_CR128) 2012; 30
KS Ivey (164_CR133) 2018; 71
OV Britanova (164_CR23) 2014; 192
AM Wertheimer (164_CR46) 2014; 192
CG Vinuesa (164_CR109) 2010; 237
CE Sayegh (164_CR99) 2003; 4
R Cioncada (164_CR129) 2017; 12
K Kolibab (164_CR19) 2005; 2
S Moberley (164_CR157) 2013; 1
AL Cunningham (164_CR179) 2018; 217
A Nguyen (164_CR187) 2018; 9
JK Gardner (164_CR72) 2017; 38
S Khurana (164_CR103) 2012; 8
S Dutta (164_CR184) 2016; 152
G Pawelec (164_CR194) 2001; 122
WC Gruber (164_CR166) 2012; 1263
RW Johnson (164_CR10) 2010; 8
TF Schwarz (164_CR30) 2018; 14
H Lal (164_CR173) 2015; 372
K Haberthur (164_CR191) 2013; 2
R Baxter (164_CR181) 2013; 131
A Domnich (164_CR28) 2017; 35
CL Krone (164_CR152) 2014; 2
MM Steger (164_CR78) 1996; 105
Y Yao (164_CR188) 2014; 415
W Tu (164_CR61) 2016; 7
C Paula (164_CR80) 2009; 10
G Falkenhorst (164_CR165) 2017; 12
MG Cusi (164_CR143) 2010; 7
V Decman (164_CR68) 2010; 184
Y Lin (164_CR83) 2016; 13
MN Oxman (164_CR175) 2005; 352
T Hagan (164_CR199) 2015; 33
S Mahbub (164_CR32) 2011; 7
BB Blomberg (164_CR98) 2013; 57
EJ Yager (164_CR125) 2008; 205
R Chlibek (164_CR178) 2016; 34
164_CR171
D Frasca (164_CR97) 2004; 172
RP Stephan (164_CR85) 1996; 8
L Lazuardi (164_CR40) 2005; 114
J Nikolich-Zugich (164_CR5) 2014; 193
A Pezeshki (164_CR202) 2019; 18
Alejandra Pera (164_CR3) 2015; 82
D Frasca (164_CR102) 2015; 195
WA Howard (164_CR94) 2006; 9
JL Uhrlaub (164_CR111) 2016; 12
J Falloon (164_CR149) 2017; 216
cr-split#-164_CR209.1
H Kraicer-Melamed (164_CR155) 2016; 34
cr-split#-164_CR209.2
M Rondy (164_CR11) 2017; 75
A Wagner (164_CR14) 2018; 8
C Kityo (164_CR114) 2018; 128
GA Poland (164_CR203) 2017; 36
Q Ouyang (164_CR24) 2003; 23
K Goodwin (164_CR16) 2006; 24
A Le Page (164_CR66) 2018; 105
KL Gibson (164_CR91) 2009; 8
S Prakash (164_CR81) 2014; 2014
AS McKee (164_CR35) 2017; 47
D Higgins (164_CR148) 2016; 34
MT Zimmermann (164_CR207) 2016; 11
H Li (164_CR197) 2014; 54
D Frasca (164_CR100) 2007; 179
G Taylor (164_CR190) 2017; 35
MT Osterholm (164_CR116) 2011; 12
AL Cunningham (164_CR172) 2016; 375
VA Morrison (164_CR12) 2015; 60
A Panda (164_CR73) 2010; 184
A Cherukuri (164_CR142) 2013; 20
JS Lefebvre (164_CR124) 2016; 6
B Bagga (164_CR144) 2015; 212
B Simell (164_CR162) 2008; 15
KM Quinn (164_CR25) 2018; 23
D Kostova (164_CR115) 2013; 8
J Sprent (164_CR45) 2011; 12
BD Rudd (164_CR49) 2011; 108
KR Renkema (164_CR52) 2014; 192
O Briceno (164_CR69) 2016; 15
RB Kennedy (164_CR208) 2016; 7
R Jin (164_CR89) 2008; 21
D Roumanes (164_CR140) 2018; 218
B Zheng (164_CR127) 2007; 179
PL Gozalo (164_CR9) 2012; 60
E Fuentes (164_CR2) 2017; 89
I Kang (164_CR123) 2004; 173
AC Shaw (164_CR33) 2010; 22
K Stiasny (164_CR22) 2012; 7
SR Hadrup (164_CR54) 2006; 176
AR Falsey (164_CR131) 2005; 352
I Spyridopoulos (164_CR196) 2016; 15
L Cicin-Sain (164_CR57) 2012; 8
AN Davydov (164_CR105) 2018; 9
EE Walsh (164_CR145) 2004; 190
CP Chong (164_CR151) 2008; 101
Thomas Hagan (164_CR200) 2017; 10
G Li (164_CR65) 2012; 18
JG Schenkein (164_CR18) 2008; 26
JJ Goronzy (164_CR64) 2001; 75
164_CR183
DK Dunn-Walters (164_CR104) 2016; 183
Y Hagiwara (164_CR158) 2003; 170
ME Al-Sofiani (164_CR38) 2019; 33
JP Legg (164_CR139) 2003; 168
N Jiang (164_CR107) 2013; 5
SPH van den Berg (164_CR60) 2018; 9
JJ Goronzy (164_CR50) 2015; 194
Y Jing (164_CR74) 2009; 70
LM Cullen (164_CR150) 2017; 13
D Frasca (164_CR95) 2014; 54
N Lee (164_CR136) 2013; 57
SM Kaech (164_CR48) 2002; 2
A Weinberg (164_CR170) 2010; 342
Y Aydar (164_CR110) 2003; 171
YS Kwon (164_CR135) 2017; 17
T Pritz (164_CR93) 2015; 45
CA Robertson (164_CR29) 2016; 15
F Listi (164_CR92) 2006; 1089
L Cicin-Sain (164_CR47) 2007; 104
BR Becklund (164_CR27) 2016; 6
S Sasaki (164_CR21) 2011; 121
A Gordon (164_CR8) 2018; 5
JE McElhaney (164_CR122) 2016; 7
PJ Openshaw (164_CR137) 2013; 372
R Rappuoli (164_CR15) 2014; 111
K Russell (164_CR117) 2018; 36
YC Wu (164_CR108) 2012; 3
KE Schmader (164_CR176) 2010; 58
G Del Giudice (164_CR34) 2018; 39
References_xml – volume: 105
  start-page: 544
  issue: 3
  year: 1996
  ident: 164_CR78
  publication-title: Clin Exp Immunol
  doi: 10.1046/j.1365-2249.1996.d01-790.x
– volume: 34
  start-page: 3993
  issue: 34
  year: 2016
  ident: 164_CR205
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2016.06.034
– volume: 45
  start-page: 159
  issue: 2
  year: 2013
  ident: 164_CR130
  publication-title: Infect Chemother
  doi: 10.3947/ic.2013.45.2.159
– volume: 12
  start-page: e0169368
  issue: 1
  year: 2017
  ident: 164_CR165
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0169368
– volume: 12
  start-page: e0185666
  issue: 11
  year: 2017
  ident: 164_CR118
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0185666
– volume: 177
  start-page: 463
  issue: 2
  year: 1998
  ident: 164_CR146
  publication-title: J Infect Dis
  doi: 10.1086/517376
– volume: 52
  start-page: 633
  issue: 5
  year: 2011
  ident: 164_CR167
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciq207
– volume: 205
  start-page: 1589
  issue: 10
  year: 2012
  ident: 164_CR7
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jis240
– volume: 34
  start-page: 1540
  issue: 13
  year: 2016
  ident: 164_CR155
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2016.02.024
– volume: 352
  start-page: 2271
  issue: 22
  year: 2005
  ident: 164_CR175
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa051016
– volume: 82
  start-page: 50
  issue: 1
  year: 2015
  ident: 164_CR3
  publication-title: Maturitas
  doi: 10.1016/j.maturitas.2015.05.004
– volume: 5
  start-page: 171ra19
  issue: 171
  year: 2013
  ident: 164_CR107
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3004794
– volume: 60
  start-page: 900
  issue: 6
  year: 2015
  ident: 164_CR12
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciu918
– volume: 194
  start-page: 4073
  issue: 9
  year: 2015
  ident: 164_CR50
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1500046
– volume: 58
  start-page: 1634
  issue: 9
  year: 2010
  ident: 164_CR176
  publication-title: J Am Geriatr Soc
  doi: 10.1111/j.1532-5415.2010.03021.x
– volume: 2
  start-page: 141
  issue: 2
  year: 2014
  ident: 164_CR152
  publication-title: Lancet Respir Med
  doi: 10.1016/S2213-2600(13)70165-6
– volume: 9
  start-page: 2309
  year: 2018
  ident: 164_CR105
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.02309
– volume: 218
  start-page: 418
  issue: 3
  year: 2018
  ident: 164_CR140
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiy016
– volume: 71
  start-page: 1574
  issue: 14
  year: 2018
  ident: 164_CR133
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2018.02.013
– volume: 168
  start-page: 1163
  issue: 3
  year: 1988
  ident: 164_CR138
  publication-title: J Exp Med
  doi: 10.1084/jem.168.3.1163
– volume: 152
  start-page: 244
  year: 2016
  ident: 164_CR184
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2015.10.025
– volume: 138
  start-page: 486
  issue: 3
  year: 2010
  ident: 164_CR168
  publication-title: Chest
  doi: 10.1378/chest.10-0738
– volume: 9
  start-page: 395
  year: 2018
  ident: 164_CR106
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.00395
– volume: 34
  start-page: 863
  issue: 6
  year: 2016
  ident: 164_CR178
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2015.09.073
– volume: 75
  start-page: 12182
  issue: 24
  year: 2001
  ident: 164_CR64
  publication-title: J Virol
  doi: 10.1128/JVI.75.24.12182-12187.2001
– volume: 107
  start-page: 55
  year: 2018
  ident: 164_CR96
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2017.07.002
– volume: 51
  start-page: 1
  issue: 1
  year: 2003
  ident: 164_CR186
  publication-title: Cytometry B Clin Cytom
  doi: 10.1002/cyto.b.10007
– volume: 372
  start-page: 2087
  issue: 22
  year: 2015
  ident: 164_CR173
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1501184
– volume: 179
  start-page: 918
  issue: 2
  year: 2007
  ident: 164_CR100
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.2.918
– volume: 10
  start-page: a028894
  issue: 8
  year: 2017
  ident: 164_CR200
  publication-title: Cold Spring Harbor Perspectives in Biology
  doi: 10.1101/cshperspect.a028894
– volume: 194
  start-page: 5725
  issue: 12
  year: 2015
  ident: 164_CR70
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1500319
– volume: 31
  start-page: 31
  year: 2013
  ident: 164_CR43
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev-immunol-032712-100010
– volume: 7
  start-page: 104
  issue: 1
  year: 2011
  ident: 164_CR32
  publication-title: Curr Immunol Rev
  doi: 10.2174/157339511794474181
– volume: 39
  start-page: 14
  year: 2018
  ident: 164_CR34
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2018.05.001
– volume: 13
  start-page: 24
  year: 2016
  ident: 164_CR83
  publication-title: Immun Ageing
  doi: 10.1186/s12979-016-0079-7
– volume: 54
  start-page: 84
  year: 2014
  ident: 164_CR197
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2014.01.010
– volume: 6
  start-page: 30842
  year: 2016
  ident: 164_CR27
  publication-title: Sci Rep
  doi: 10.1038/srep30842
– volume: 7
  start-page: 450
  year: 2016
  ident: 164_CR208
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2016.00450
– volume: 111
  start-page: 12288
  issue: 34
  year: 2014
  ident: 164_CR15
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1402981111
– volume: 29
  start-page: 1929
  issue: 10
  year: 2011
  ident: 164_CR160
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2010.12.121
– volume: 7
  start-page: 41
  year: 2016
  ident: 164_CR122
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2016.00041
– ident: #cr-split#-164_CR209.2
– volume: 14
  start-page: 1370
  issue: 6
  year: 2018
  ident: 164_CR30
  publication-title: Hum Vaccin Immunother
  doi: 10.1080/21645515.2018.1442162
– volume: 23
  start-page: 57
  issue: 1
  year: 2003
  ident: 164_CR39
  publication-title: Immunol Allergy Clin N Am
  doi: 10.1016/S0889-8561(02)00078-4
– volume: 172
  start-page: 2155
  issue: 4
  year: 2004
  ident: 164_CR97
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.4.2155
– volume: 18
  start-page: 253
  issue: 3
  year: 2019
  ident: 164_CR202
  publication-title: Expert Rev Vaccines
  doi: 10.1080/14760584.2019.1575208
– volume: 10
  start-page: 13
  issue: 1
  year: 2009
  ident: 164_CR80
  publication-title: Biogerontology
  doi: 10.1007/s10522-008-9150-x
– volume: 45
  start-page: 738
  issue: 3
  year: 2015
  ident: 164_CR93
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201444878
– volume: 18
  start-page: 867
  issue: 5
  year: 2011
  ident: 164_CR121
  publication-title: ClinVaccine Immunol
– volume: 9
  start-page: 82
  year: 2018
  ident: 164_CR60
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.00082
– volume: 170
  start-page: 1754
  issue: 4
  year: 2003
  ident: 164_CR158
  publication-title: J Immunol
  doi: 10.4049/jimmunol.170.4.1754
– volume: 2
  start-page: 364
  issue: 2
  year: 2013
  ident: 164_CR191
  publication-title: Pathogens
  doi: 10.3390/pathogens2020364
– volume: 2
  start-page: 251
  issue: 4
  year: 2002
  ident: 164_CR48
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri778
– volume: 24
  start-page: 1159
  issue: 8
  year: 2006
  ident: 164_CR16
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2005.08.105
– volume: 192
  start-page: 2143
  issue: 5
  year: 2014
  ident: 164_CR46
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1301721
– volume: 8
  start-page: 37
  year: 2010
  ident: 164_CR10
  publication-title: BMC Med
  doi: 10.1186/1741-7015-8-37
– volume: 23
  start-page: 3512
  issue: 12
  year: 2018
  ident: 164_CR25
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2018.05.057
– volume: 12
  start-page: e1005891
  issue: 10
  year: 2016
  ident: 164_CR111
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1005891
– volume: 217
  start-page: 1750
  issue: 11
  year: 2018
  ident: 164_CR179
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiy095
– volume: 191
  start-page: 5793
  issue: 12
  year: 2013
  ident: 164_CR51
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1302509
– volume: 34
  start-page: 2870
  issue: 26
  year: 2016
  ident: 164_CR148
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2016.03.109
– volume: 104
  start-page: 19960
  issue: 50
  year: 2007
  ident: 164_CR47
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0705905104
– volume: 184
  start-page: 2518
  issue: 5
  year: 2010
  ident: 164_CR73
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0901022
– volume: 11
  start-page: 968
  issue: 6
  year: 2012
  ident: 164_CR79
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2012.00867.x
– volume: 8
  start-page: 706
  year: 2017
  ident: 164_CR26
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.00706
– volume: 128
  start-page: 2763
  issue: 7
  year: 2018
  ident: 164_CR114
  publication-title: J Clin Invest
  doi: 10.1172/JCI97377
– volume: 8
  start-page: 18
  issue: 1
  year: 2009
  ident: 164_CR91
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2008.00443.x
– volume: 216
  start-page: 1362
  issue: 11
  year: 2017
  ident: 164_CR149
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jix503
– volume: 342
  start-page: 341
  year: 2010
  ident: 164_CR170
  publication-title: Curr Top Microbiol Immunol
  doi: 10.1007/82_2010_31
– volume: 89
  start-page: 285
  issue: 1
  year: 2017
  ident: 164_CR2
  publication-title: An Acad Bras Cienc
  doi: 10.1590/0001-3765201720160487
– volume: 16
  start-page: 343
  issue: 4
  year: 2015
  ident: 164_CR31
  publication-title: Nat Immunol
  doi: 10.1038/ni.3123
– volume: 8
  start-page: 9825
  issue: 1
  year: 2018
  ident: 164_CR14
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-28111-8
– volume: 114
  start-page: 37
  issue: 1
  year: 2005
  ident: 164_CR40
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2004.02006.x
– volume: 184
  start-page: 5151
  issue: 9
  year: 2010
  ident: 164_CR68
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0902063
– volume: 8
  start-page: 509
  issue: 4
  year: 1996
  ident: 164_CR85
  publication-title: Int Immunol
  doi: 10.1093/intimm/8.4.509
– volume: 191
  start-page: 1040
  issue: 9
  year: 2015
  ident: 164_CR147
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201412-2256OC
– volume: 6
  start-page: 25051
  year: 2016
  ident: 164_CR124
  publication-title: Sci Rep
  doi: 10.1038/srep25051
– volume: 75
  start-page: 381
  issue: 5
  year: 2017
  ident: 164_CR11
  publication-title: J Infect
  doi: 10.1016/j.jinf.2017.09.010
– volume: 9
  start-page: 1553
  year: 2018
  ident: 164_CR187
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.01553
– volume: 13
  start-page: 2814
  issue: 12
  year: 2017
  ident: 164_CR150
  publication-title: Hum Vaccin Immunother
  doi: 10.1080/21645515.2017.1329069
– volume: 70
  start-page: 1210
  issue: 10
  year: 2015
  ident: 164_CR198
  publication-title: J Gerontol A Biol Sci Med Sci
  doi: 10.1093/gerona/glu171
– volume: 7
  start-page: 2111
  year: 2016
  ident: 164_CR61
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2016.02111
– volume: 179
  start-page: 6153
  issue: 9
  year: 2007
  ident: 164_CR127
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.9.6153
– volume: 15
  start-page: 389
  issue: 2
  year: 2016
  ident: 164_CR196
  publication-title: Aging Cell
  doi: 10.1111/acel.12430
– volume: 26
  start-page: 5521
  issue: 43
  year: 2008
  ident: 164_CR18
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2008.07.071
– volume: 172
  start-page: 7432
  issue: 12
  year: 2004
  ident: 164_CR185
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.12.7432
– volume: 18
  start-page: 1518
  issue: 10
  year: 2012
  ident: 164_CR65
  publication-title: Nat Med
  doi: 10.1038/nm.2963
– volume: 4
  start-page: e1000159
  issue: 9
  year: 2008
  ident: 164_CR163
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1000159
– volume: 22
  start-page: 507
  issue: 4
  year: 2010
  ident: 164_CR33
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2010.05.003
– volume: 2014
  start-page: 436438
  year: 2014
  ident: 164_CR81
  publication-title: Mediat Inflamm
  doi: 10.1155/2014/436438
– volume: 38
  start-page: 40
  year: 2017
  ident: 164_CR72
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2017.07.002
– volume: 107
  start-page: 5465
  issue: 12
  year: 2010
  ident: 164_CR86
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1000834107
– volume: 33
  start-page: 451
  issue: 6
  year: 2019
  ident: 164_CR38
  publication-title: J Diabetes Complicat
  doi: 10.1016/j.jdiacomp.2019.03.007
– volume: 57
  start-page: 354
  issue: 1–3
  year: 2013
  ident: 164_CR98
  publication-title: Immunol Res
  doi: 10.1007/s12026-013-8440-9
– volume: 125
  start-page: 4666
  issue: 12
  year: 2015
  ident: 164_CR84
  publication-title: J Clin Invest
  doi: 10.1172/JCI83024
– volume: 35
  start-page: 469
  issue: 3
  year: 2017
  ident: 164_CR190
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2016.11.054
– volume: 15
  start-page: 14
  issue: 1
  year: 2016
  ident: 164_CR69
  publication-title: Aging Cell
  doi: 10.1111/acel.12384
– volume: 22
  start-page: 253
  issue: 2–3
  year: 2000
  ident: 164_CR41
  publication-title: Immunol Res
  doi: 10.1385/IR:22:2-3:253
– volume: 25
  start-page: 989
  issue: 6
  year: 2006
  ident: 164_CR113
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.10.011
– volume: 21
  start-page: 233
  issue: 2
  year: 2008
  ident: 164_CR89
  publication-title: Int J Mol Med
– volume: 17
  start-page: 785
  issue: 1
  year: 2017
  ident: 164_CR135
  publication-title: BMC Infect Dis
  doi: 10.1186/s12879-017-2897-4
– volume: 237
  start-page: 72
  issue: 1
  year: 2010
  ident: 164_CR109
  publication-title: Immunol Rev
  doi: 10.1111/j.1600-065X.2010.00937.x
– volume: 8
  start-page: 896
  year: 2017
  ident: 164_CR71
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.00896
– volume: 213
  start-page: 1872
  issue: 12
  year: 2016
  ident: 164_CR13
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiw047
– volume: 352
  start-page: 1749
  issue: 17
  year: 2005
  ident: 164_CR131
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa043951
– volume: 212
  start-page: 1719
  issue: 11
  year: 2015
  ident: 164_CR144
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiv281
– volume: 5
  start-page: 1
  issue: 1
  year: 2018
  ident: 164_CR8
  publication-title: Curr Epidemiol Rep
  doi: 10.1007/s40471-018-0136-1
– volume: 29
  start-page: 3982
  issue: 23
  year: 2011
  ident: 164_CR161
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2011.03.081
– volume: 11
  start-page: e0152034
  issue: 3
  year: 2016
  ident: 164_CR207
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0152034
– volume: 8
  start-page: e1002849
  issue: 8
  year: 2012
  ident: 164_CR57
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1002849
– volume: 195
  start-page: 2134
  issue: 5
  year: 2015
  ident: 164_CR102
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1500520
– volume: 26
  start-page: 728
  issue: 4
  year: 2013
  ident: 164_CR169
  publication-title: Clin Microbiol Rev
  doi: 10.1128/CMR.00052-13
– volume: 23
  start-page: 247
  issue: 4
  year: 2003
  ident: 164_CR24
  publication-title: J Clin Immunol
  doi: 10.1023/A:1024580531705
– volume: 208
  start-page: 305
  issue: 3-4
  year: 2019
  ident: 164_CR59
  publication-title: Medical Microbiology and Immunology
  doi: 10.1007/s00430-019-00602-z
– volume: 68
  start-page: 84
  issue: 2
  year: 2016
  ident: 164_CR1
  publication-title: Rev Investig Clin
– volume: 176
  start-page: 2645
  issue: 4
  year: 2006
  ident: 164_CR54
  publication-title: J Immunol
  doi: 10.4049/jimmunol.176.4.2645
– volume: 15
  start-page: 1495
  issue: 12
  year: 2016
  ident: 164_CR29
  publication-title: Expert Rev Vaccines
  doi: 10.1080/14760584.2016.1254044
– volume: 12
  start-page: 478
  issue: 6
  year: 2011
  ident: 164_CR45
  publication-title: Nat Immunol
  doi: 10.1038/ni.2018
– volume: 192
  start-page: 151
  issue: 1
  year: 2014
  ident: 164_CR52
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1301453
– volume: 108
  start-page: 13694
  issue: 33
  year: 2011
  ident: 164_CR49
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1107594108
– volume: 178
  start-page: 6912
  issue: 11
  year: 2007
  ident: 164_CR77
  publication-title: J Immunol
  doi: 10.4049/jimmunol.178.11.6912
– volume: 108
  start-page: 20012
  issue: 50
  year: 2011
  ident: 164_CR87
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1116110108
– volume: 31
  start-page: 685
  issue: 4
  year: 2013
  ident: 164_CR58
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2012.11.041
– volume: 105
  start-page: 128
  year: 2018
  ident: 164_CR66
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2018.01.005
– ident: 164_CR183
  doi: 10.1128/JVI.00269-18
– volume: 33
  start-page: D60
  issue: Suppl 4
  year: 2015
  ident: 164_CR154
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2015.05.102
– volume: 52
  start-page: 673
  issue: 7
  year: 2018
  ident: 164_CR177
  publication-title: Ann Pharmacother
  doi: 10.1177/1060028018758431
– volume: 121
  start-page: 3109
  issue: 8
  year: 2011
  ident: 164_CR21
  publication-title: J Clin Invest
  doi: 10.1172/JCI57834
– volume: 5
  start-page: 775
  issue: 6
  year: 2009
  ident: 164_CR119
  publication-title: Aging Health
  doi: 10.2217/ahe.09.69
– volume: 36
  start-page: 5350
  issue: 36
  year: 2017
  ident: 164_CR203
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2017.07.062
– volume: 135
  start-page: 434
  issue: 6
  year: 1981
  ident: 164_CR36
  publication-title: West J Med
– volume: 171
  start-page: 5975
  issue: 11
  year: 2003
  ident: 164_CR110
  publication-title: J Immunol
  doi: 10.4049/jimmunol.171.11.5975
– volume: 375
  start-page: 1019
  issue: 11
  year: 2016
  ident: 164_CR172
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1603800
– volume: 8
  start-page: 1489
  year: 2013
  ident: 164_CR37
  publication-title: Clin Interv Aging
  doi: 10.2147/CIA.S51152
– volume: 8
  start-page: e1002920
  issue: 9
  year: 2012
  ident: 164_CR103
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1002920
– volume: 203
  start-page: 1415
  issue: 10
  year: 2011
  ident: 164_CR76
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jir048
– volume: 372
  start-page: 359
  year: 2013
  ident: 164_CR137
  publication-title: Curr Top Microbiol Immunol
  doi: 10.1007/978-3-642-38919-1_18
– volume: 190
  start-page: 373
  issue: 2
  year: 2004
  ident: 164_CR145
  publication-title: J Infect Dis
  doi: 10.1086/421524
– volume: 121
  start-page: 187
  issue: 1–3
  year: 2000
  ident: 164_CR195
  publication-title: Mech Ageing Dev
– volume: 1089
  start-page: 487
  year: 2006
  ident: 164_CR92
  publication-title: Ann N Y Acad Sci
  doi: 10.1196/annals.1386.013
– volume: 3
  start-page: 193
  year: 2012
  ident: 164_CR108
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2012.00193
– volume: 191
  start-page: 1710
  issue: 10
  year: 2005
  ident: 164_CR141
  publication-title: J Infect Dis
  doi: 10.1086/429695
– volume: 205
  start-page: 711
  issue: 3
  year: 2008
  ident: 164_CR125
  publication-title: J Exp Med
  doi: 10.1084/jem.20071140
– volume: 25
  start-page: 504
  issue: 4
  year: 2013
  ident: 164_CR6
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2013.07.006
– volume: 183
  start-page: 50
  issue: 1
  year: 2016
  ident: 164_CR104
  publication-title: Clin Exp Immunol
  doi: 10.1111/cei.12700
– volume: 131
  start-page: e1389
  issue: 5
  year: 2013
  ident: 164_CR181
  publication-title: Pediatrics
  doi: 10.1542/peds.2012-3303
– volume: 19
  start-page: 10
  issue: 1
  year: 2018
  ident: 164_CR4
  publication-title: Nat Immunol
  doi: 10.1038/s41590-017-0006-x
– volume: 9
  start-page: 149
  issue: 1
  year: 2006
  ident: 164_CR90
  publication-title: Rejuvenation Res
  doi: 10.1089/rej.2006.9.149
– volume: 88
  start-page: 135
  issue: 2
  year: 2010
  ident: 164_CR156
  publication-title: J Mol Med (Berl)
  doi: 10.1007/s00109-009-0579-4
– volume: 7
  start-page: e34145
  issue: 3
  year: 2012
  ident: 164_CR22
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0034145
– volume: 33
  start-page: 5294
  issue: 40
  year: 2015
  ident: 164_CR199
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2015.03.072
– volume: 54
  start-page: 116
  year: 2014
  ident: 164_CR95
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2014.01.004
– volume: 69
  start-page: 197
  issue: 2
  year: 2018
  ident: 164_CR134
  publication-title: Clinical Infectious Diseases
  doi: 10.1093/cid/ciy991
– volume: 168
  start-page: 5893
  issue: 11
  year: 2002
  ident: 164_CR62
  publication-title: J Immunol
  doi: 10.4049/jimmunol.168.11.5893
– volume: 197
  start-page: 475
  issue: 4
  year: 2003
  ident: 164_CR42
  publication-title: J Exp Med
  doi: 10.1084/jem.20021765
– volume: 186
  start-page: 2454
  issue: 4
  year: 2011
  ident: 164_CR159
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1002837
– volume: 33
  start-page: 5241
  issue: 40
  year: 2015
  ident: 164_CR204
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2015.05.098
– volume: 9
  start-page: 117
  issue: 1
  year: 2006
  ident: 164_CR94
  publication-title: Rejuvenation Res
  doi: 10.1089/rej.2006.9.117
– volume: 20
  start-page: 239
  issue: 2
  year: 2013
  ident: 164_CR142
  publication-title: Clin Vaccine Immunol
  doi: 10.1128/CVI.00580-12
– volume: 168
  start-page: 633
  issue: 6
  year: 2003
  ident: 164_CR139
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200210-1148OC
– volume: 90
  start-page: 213
  issue: 2
  year: 1999
  ident: 164_CR55
  publication-title: Clin Immunol
  doi: 10.1006/clim.1998.4638
– volume: 8
  start-page: e66312
  issue: 6
  year: 2013
  ident: 164_CR115
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0066312
– volume: 1263
  start-page: 15
  year: 2012
  ident: 164_CR166
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2012.06673.x
– volume: 15
  start-page: 1391
  issue: 9
  year: 2008
  ident: 164_CR162
  publication-title: Clin Vaccine Immunol
  doi: 10.1128/CVI.00110-08
– volume: 13
  start-page: 657
  issue: 5
  year: 2014
  ident: 164_CR201
  publication-title: Expert Rev Vaccines
  doi: 10.1586/14760584.2014.905744
– volume: 218
  start-page: S127
  issue: suppl_2
  year: 2018
  ident: 164_CR182
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiy382
– volume: 9
  start-page: 185
  issue: 3
  year: 2009
  ident: 164_CR20
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2508
– volume: 122
  start-page: 132
  issue: 2
  year: 2001
  ident: 164_CR194
  publication-title: Mech Ageing Dev
  doi: 10.1016/S0047-6374(00)00240-2
– volume: 11
  start-page: e1005027
  issue: 7
  year: 2015
  ident: 164_CR112
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1005027
– volume: 130
  start-page: 681
  issue: 10
  year: 2009
  ident: 164_CR88
  publication-title: Mech Ageing Dev
  doi: 10.1016/j.mad.2009.08.003
– volume: 35
  start-page: 513
  issue: 4
  year: 2017
  ident: 164_CR28
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2016.12.011
– volume: 10
  start-page: 274
  issue: 2
  year: 2011
  ident: 164_CR82
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2010.12.002
– volume: 4
  start-page: 586
  issue: 6
  year: 2003
  ident: 164_CR99
  publication-title: Nat Immunol
  doi: 10.1038/ni923
– volume: 36
  start-page: 1272
  issue: 10
  year: 2018
  ident: 164_CR117
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2018.01.045
– volume: 22
  start-page: 577
  issue: 7
  year: 2005
  ident: 164_CR132
  publication-title: Drugs Aging
  doi: 10.2165/00002512-200522070-00004
– volume: 16
  start-page: 55
  issue: 1
  year: 2017
  ident: 164_CR180
  publication-title: Expert Rev Vaccines
  doi: 10.1080/14760584.2016.1213632
– volume: 192
  start-page: 2689
  issue: 6
  year: 2014
  ident: 164_CR23
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1302064
– volume: 193
  start-page: 70
  year: 2018
  ident: 164_CR120
  publication-title: Clin Immunol
  doi: 10.1016/j.clim.2018.01.011
– volume: 60
  start-page: 1260
  issue: 7
  year: 2012
  ident: 164_CR9
  publication-title: J Am Geriatr Soc
  doi: 10.1111/j.1532-5415.2012.04048.x
– volume: 180
  start-page: 5283
  issue: 8
  year: 2008
  ident: 164_CR101
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.8.5283
– volume: 2
  start-page: 10
  year: 2005
  ident: 164_CR19
  publication-title: Immun Ageing
  doi: 10.1186/1742-4933-2-10
– volume: 79
  start-page: 314
  issue: 1
  year: 2011
  ident: 164_CR17
  publication-title: Infect Immun
  doi: 10.1128/IAI.00768-10
– volume: 372
  start-page: 1114
  issue: 12
  year: 2015
  ident: 164_CR153
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1408544
– volume: 101
  start-page: 1141
  issue: 11
  year: 2008
  ident: 164_CR151
  publication-title: South Med J
  doi: 10.1097/SMJ.0b013e318181d5b5
– volume: 1
  start-page: CD000422
  year: 2013
  ident: 164_CR157
  publication-title: Cochrane Database Syst Rev
  doi: 10.1002/14651858.CD000422.pub3
– volume: 12
  start-page: e0182498
  issue: 8
  year: 2017
  ident: 164_CR193
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0182498
– volume: 33
  start-page: 363
  issue: 3
  year: 2011
  ident: 164_CR75
  publication-title: Age (Dordr)
  doi: 10.1007/s11357-010-9191-3
– volume: 128
  start-page: 4429
  issue: 10
  year: 2018
  ident: 164_CR174
  publication-title: Journal of Clinical Investigation
  doi: 10.1172/JCI121484
– volume: 36
  start-page: 288
  issue: 2
  year: 2012
  ident: 164_CR44
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.02.006
– volume: 415
  start-page: 1
  year: 2014
  ident: 164_CR188
  publication-title: J Immunol Methods
  doi: 10.1016/j.jim.2014.10.010
– volume: 12
  start-page: e0185843
  issue: 10
  year: 2017
  ident: 164_CR129
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0185843
– volume: 70
  start-page: 777
  issue: 10
  year: 2009
  ident: 164_CR74
  publication-title: Hum Immunol
  doi: 10.1016/j.humimm.2009.07.005
– ident: #cr-split#-164_CR209.1
– volume: 172
  start-page: 3437
  issue: 6
  year: 2004
  ident: 164_CR126
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.6.3437
– volume: 47
  start-page: 44
  year: 2017
  ident: 164_CR35
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2017.06.005
– volume: 12
  start-page: 36
  issue: 1
  year: 2011
  ident: 164_CR116
  publication-title: Lancet Infect Dis
  doi: 10.1016/S1473-3099(11)70295-X
– volume: 24
  start-page: 965
  issue: 6
  year: 2018
  ident: 164_CR189
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid2406.172114
– volume: 8
  start-page: 739
  issue: 1
  year: 2018
  ident: 164_CR206
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-17735-x
– volume: 30
  start-page: 4341
  issue: 29
  year: 2012
  ident: 164_CR128
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2011.09.061
– volume: 153
  start-page: 1072
  issue: 3
  year: 1996
  ident: 164_CR164
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/ajrccm.153.3.8630547
– volume: 57
  start-page: 1069
  issue: 8
  year: 2013
  ident: 164_CR136
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/cit471
– volume: 19
  start-page: 123
  issue: 1
  year: 2018
  ident: 164_CR192
  publication-title: Respir Res
  doi: 10.1186/s12931-018-0784-1
– volume: 102
  start-page: 977
  issue: 4
  year: 2017
  ident: 164_CR67
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.3RI0716-335R
– volume: 2
  start-page: eaam9304
  issue: 12
  year: 2017
  ident: 164_CR53
  publication-title: Science Immunology
  doi: 10.1126/sciimmunol.aam9304
– volume: 7
  start-page: 14
  year: 2010
  ident: 164_CR143
  publication-title: Immun Ageing
  doi: 10.1186/1742-4933-7-14
– volume: 15
  start-page: 186
  issue: 4
  year: 2015
  ident: 164_CR56
  publication-title: Immune Netw
  doi: 10.4110/in.2015.15.4.186
– volume: 173
  start-page: 673
  issue: 1
  year: 2004
  ident: 164_CR123
  publication-title: J Immunol
  doi: 10.4049/jimmunol.173.1.673
– volume: 193
  start-page: 2622
  issue: 6
  year: 2014
  ident: 164_CR5
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1401174
– ident: 164_CR171
– volume: 4
  start-page: 107
  year: 2013
  ident: 164_CR63
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2013.00107
SSID ssj0034964
Score 2.6265428
SecondaryResourceType review_article
Snippet The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased...
The age-related dysregulation and decline of the immune system--collectively termed "immunosenescence"--has been generally associated with an increased...
The age-related dysregulation and decline of the immune system-collectively termed "immunosenescence"-has been generally associated with an increased...
Abstract The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased...
SourceID doaj
pubmedcentral
proquest
gale
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Enrichment Source
Index Database
Publisher
StartPage 25
SubjectTerms Adaptive immunity
Aging
Aging (Biology)
Antibodies
B cell
B cells
Biomedical and Life Sciences
Biomedicine
Clinical Nutrition
Clinical outcomes
Elderly
Geriatrics/Gerontology
Gerontology
Health aspects
Immune response
Immune system
Immunology
Immunosenescence
Immunotherapy
Lymphocytes
Lymphocytes B
Medical research
Older people
Pathogenic microorganisms
Pathogens
Physiological aspects
Public Health
Review
T cell
T cells
Vaccination
Vaccine development
Vaccines
SummonAdditionalLinks – databaseName: Directory of Open Access Journals (DOAJ)
  dbid: DOA
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEB_kUPFFdFWsrhJBFJRySZNLmsdTPBT08EHx3kI2TXC5oyvt3oH_vTNpu1oP9cWHfWmm3XY-M2TmNwBPuceko2lEmZKUpVK8Kb0yqeQJ3WESXlifcWbfm-Pj-uTEfvxl1BfVhA3wwAPj9hNfKe9VaGoTVVR6lapqJTBOVo3Gx-U2X27slEwNPphQ0NV4hilqvd9jVDNUF0Q_rUo7i0IZrP-yS75cJvnbWWkOQUe34Oa4d2SHwzvfhiuxXcC1YZrk9wVc_zCeky9gOXTdsi_xLPkusmdsurDpTu-AfEddIZue_Fwg02a-bVge18cufKBnsDWRRNYNNbSxvwufj958ev22HKcnlEErvS0bbxMG53gQccfQ-ETZVS2SiZJ7dHM8aq2CtiurdJBBRQxmXnPCisEUruaNvAd77aaN94Fpg6RSVh5zO8yQRJ3qwFcVst_EgzqmAvjETRdGaHGacHHmcopRazcIwKEAHAnA2QJe7G75NuBq_I34FYloR0iQ2PkCKoobFcX9S1EKeE4CdmS4-HLBj_0H-IkEgeUOaeuHm7NKFLCcUaLBhfnypCJuNPjeVZUl5HtUvAKe7JbpTipia-PmPNNIAoC0sgAzU63Zl81X2vXXDPpNzSJCmQJeTkr488__yLgH_4NxD-FGlS3HlkIuYW_bncdHcDVcbNd99zjb3Q83xyyJ
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: SpringerLINK Contemporary 1997-Present
  dbid: RSV
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bi9UwEB50vSCIl6Ni9SgRRMGlmDY5afq4iouCLoK3fQtpmujBpZX27IL_3pm0PVJXBX3oSzNpk3SuzcwXgIfcYtBR11kaghCplLxOrSxCygOqw5DZrLQRZ_Z1cXCgDw_Lt2Mddz9lu09bklFTR7HW6mmPlqmg3B66lEzLs3BuRWAzFKK_-zipXwJAl-P25W-7zQxQxOk_rY1PZ0j-sk0arc_-1f8a9zW4MjqbbG_gjutwxjcLuDAcP_l9ARffjBvrC7g8_L5jQ1XSApZD2S775I-C7Tx7xKYbbff1BohXVFbS9qQoHekGZpuaxfP-2Il19Ey2JhLPuiEJ1_c34cP-i_fPX6bj8QupU1Jt0tqWAa27X3l0OWobKDzTWSi84Bb1JPdKSafKqpTKCSc9WkOrOIHNYAyoeS1uwU7TNv42MFUgqRC5xeAQQ6xMB-14lSM7FH6lfUiAT9_EuBGbnI7IODIxRtHKDKtocBUNraIpE3iy7fJtAOb4G_Ez-tBbQsLUjjfa7rMZRdQEXklrpat14aWXqgp5XmXokeW1wpHqBB4TmxiSfBycs2MBA06RMLTMHvmO6N3lWQLLGSVKrJs3T4xmRo3RmzwvCTof2TeBB9tm6klZcI1vjyONIATJUiRQzBh0NrN5S7P-ElHDqdokk0UCuxOb_nz5Hxfuzj9R34VLeeTzMs3EEnY23bG_B-fdyWbdd_ejmP4Ac0g1MA
  priority: 102
  providerName: Springer Nature
Title Immunosenescence and human vaccine immune responses
URI https://link.springer.com/article/10.1186/s12979-019-0164-9
https://www.proquest.com/docview/2292632349
https://www.proquest.com/docview/2293024393
https://pubmed.ncbi.nlm.nih.gov/PMC6743147
https://doaj.org/article/f0b4aa4cd87e4e46bf22b16632d68018
Volume 16
WOSCitedRecordID wos000485862300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVADU
  databaseName: Open Access: BioMedCentral Open Access Titles
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: RBZ
  dateStart: 20040101
  isFulltext: true
  titleUrlDefault: https://www.biomedcentral.com/search/
  providerName: BioMedCentral
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: DOA
  dateStart: 20040101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: M~E
  dateStart: 20040101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: 7X7
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: BENPR
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: PIMPY
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVAVX
  databaseName: SpringerLINK Contemporary 1997-Present
  customDbUrl:
  eissn: 1742-4933
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0034964
  issn: 1742-4933
  databaseCode: RSV
  dateStart: 20041201
  isFulltext: true
  titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22
  providerName: Springer Nature
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED-xDRAvfJQhAqUKEgIJFC2JPTt-QhvaxCRWVeOrPFmuY0PFlIykm8R_j89xOoWJvfDQSokvqd0734d9_h3Ai1S5oKMss8RaQhJK0zJRlNsktU4d2kxlQnmc2Q98Oi3mczELC25tSKvsdaJX1GWtcY18J88FQosTKt6e_UqwahTuroYSGhuwhUhlTs639g-ms5NeFyMaOg17mVnBdlpn3TjmB-GH0UQMrJEH7b-qmq-mS_61Z-pN0eG9_x3EfbgbnNB4r5OaB3DDVCO41ZWl_D2C28dhw30E4-74bvzVnFrVmPhl3N-om58PgRzh8ZK6RYWpUUfEqipjX_cvvlAa3xEvkcTETZeMa9pt-Hx48Ond-ySUYUg0o2yVlEpYZ-XNrnGuR6kshmlFZrkhqXL6MjWMUc3EQlCmiabGWUXFUgSdcbFgkZbkEWxWdWUeQ8y4IyUkVy5IdKFWVthCp4vciQU3u4WxEaQ9O6QOGOVYKuNU-lilYLLjoHQclMhBKSJ4vX7krAPouI54H3m8JkRsbX-jbr7LMFWlTRdUKarLghtqKFvYPF9kzjPLS-Z6WkTwCiVEogZwndMqHGRwQ0QsLbmHPqTz8vIsgvGA0s1cPWzupUQGzdHKSxGJ4Pm6GZ_EbLjK1OeehiCSpCAR8IFsDkY2bKmWPzx6OJ46ySiP4E0vxZc__s8_7sn1XX0Kd3I_qUSSkTFsrppz8wxu6ovVsm0msMHn3H8XkzBBJ37tw13Njo5n39zVyccvfwC3iUFw
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VLa8LjwVEYAEj8ZBAURPb6yQHhFpo1VW3qwoV0ZtxHBtWVElJtkX9U_xGPHlsFSp664FDLvEksZOZbzzx-BuAF4FyQUeWhb61jPmcB5mveGT9wDo4tKEKE1XzzE6j2Sw-OEj2VuB3txcG0yo7TKyBOis0_iNfozRBanHGk_dHP32sGoWrq10JjUYtdszpLxeyVe8mH933fUnp1ub-h22_rSrga8HFws9UYp3TMmPjPGmmLEYdcWgjwwLlzD8wQnAtkjThQjPNjQN5JQLkUHGhTRxkzN33CqxyxsV4AKsbm7O9Tx32I_s6b9dOw1isVc6bRpiPhIfgftLzfnWRgPOu4Hx65l9rtLXr27r9v720O3CrnWST9cYq7sKKyYdwrSm7eTqE67ttQsEQRs32ZPLFHFpVGvKKdCeK8sc9YBPcPlNU6BA0YiBReUbquobkRGm8B5mjiCFlk2xsqvvw-VLG9gAGeZGbh0BE5EQZo8oFwS6UDGMb6yClTu0jM46N9SDoPr_ULQc7lgI5lHUsFgvZaIx0GiNRY2TiwZvlJUcNAclFwhuoU0tB5A6vTxTlN9lCkbRBypXiOosjww0XqaU0Dd3Mk2bC9TT24DVqpESEc53Tqt2o4YaIXGFyHefIbhZLQw9GPUmHTLrf3GmlbJGxkmcq6cHzZTNeidl-uSmOaxmGTJkJ8yDq2UJvZP2WfP69ZkfHXTUhjzx421nN2cP_-eIeXdzVZ3Bje393KqeT2c5juElrg078kI1gsCiPzRO4qk8W86p82gICga-XbU5_AJchlZ4
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zb9QwEB5BgQoJcSwgAgsYCYEEiprEruM8lmNFRVlVXO2b5fiAFVW2SraV-PfM5FgUCkiIh7zE48R2xnPEM98APE4MOh3OpXEInMdCJC42Ig9xElAchtSkhWlxZvfy-VwdHhb7fZ3TZoh2H44ku5wGQmmqVlvHLnRbXMmtBrVUTnE-dEkRF-fhgkBHhmK63n_4PIhiAkMX_VHmb7uNlFGL2X9WMp-NlvzlyLTVRLNr_z2H63C1N0LZTsc1N-CcryZwqStL-X0Cm-_6A_cJXOl-67EuW2kC0y6dlx34o2Bqz56w4cay_nYT-C6lmywbEqCWZAYzlWNtHUB2aiw9ky2IxLO6C871zS34NHv98eWbuC_LEFsp5Cp2pgio9f22R1PEmUBum0pD7nliUH4mXkphZVEWQlpuhUctaWRCIDToG6rE8duwUS0rfweYzJGU88yg04iuV6qCskmZIZvkflv5EEEyfB9te8xyKp1xpFvfRUndraLGVdS0irqI4Nm6y3EH2PE34hf00deEhLXd3ljWX3S_dXVISmGMsE7lXnghy5BlZYqWWuYkjlRF8JRYRpNEwMFZ0yc24BQJW0vvkE2JVl-WRjAdUeJOtuPmgel0L0kanWUFQeojK0fwaN1MPSk6rvLLk5aGE7JkwSPIR8w6mtm4pVp8bdHEKQslFXkEzweW_fnyPy7c3X-ifgib-69mem93_vYeXM5ali_ilE9hY1Wf-Ptw0Z6uFk39oN29PwCx4ED4
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immunosenescence+and+human+vaccine+immune+responses&rft.jtitle=Immunity+%26+ageing&rft.au=Crooke%2C+Stephen+N&rft.au=Ovsyannikova%2C+Inna+G&rft.au=Poland%2C+Gregory+A&rft.au=Kennedy%2C+Richard+B&rft.date=2019-09-13&rft.pub=BioMed+Central+Ltd&rft.issn=1742-4933&rft.eissn=1742-4933&rft.volume=16&rft.issue=1&rft_id=info:doi/10.1186%2Fs12979-019-0164-9&rft.externalDocID=A600197621
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1742-4933&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1742-4933&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1742-4933&client=summon