Bik promotes proteasomal degradation to control low-grade inflammation

Although chronic low-grade inflammation does not cause immediate clinical symptoms, over the longer term, it can enhance other insults or age-dependent damage to organ systems and thereby contribute to age-related disorders, such as respiratory disorders, heart disease, metabolic disorders, autoimmu...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 134; no. 4
Main Authors:	Mebratu, Yohannes A., Jones, Jane T., Liu, Congjian, Negasi, Zerihun H., Rahman, Mizanur, Rojas-Quintero, Joselyn, O’Connor, George T., Gao, Wei, Dupuis, Josée, Cho, Michael H., Litonjua, Augusto A., Randell, Scott, Tesfaigzi, Yohannes
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 15.02.2024
Subjects:	Allergic reaction Allergy Animals Apoptosis Apoptosis Regulatory Proteins Apoptotic proteins Autoimmunity Development and progression Diseases Emphysema Emphysema, Pulmonary Female Genetic aspects Genetic engineering Health aspects Heart diseases Hexosyltransferases Humans Inflammation Inflammation - genetics Male Massachusetts Mice Mitochondrial Proteins New Mexico Nuclear Proteins Physiological aspects Proteasome Endopeptidase Complex - genetics Proteins Proteolysis Proto-Oncogene Proteins c-bcl-2 Single nucleotide polymorphisms Tetracycline Tetracyclines United States New Mexico Massachusetts Inflammation NF-kappaB Peptides Apoptosis
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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