Disseminated Histoplasmosis in Persons Living with HIV, France and Overseas Territories,1992–2021

Disseminated histoplasmosis is a major issue among persons with advanced HIV in the Americas; it might also affect persons in sub-Saharan Africa, the Caribbean, and Asia and can be mistaken for other infections. By using 1992-2021 data from the French hospital database on HIV, we analyzed 198,798 pe...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 31; no. 7; pp. 1377 - 1385
Main Authors: Nacher, Mathieu, Marshall, Esaïe, Bani-Sadr, Firouze, Peugny, Sandrine, Denis, Blandine, Ouedraogo, Elise, Gallien, Sebastien, Meybeck, Agnes, Françoise, Ugo, Adenis, Antoine, Vignier, Nicolas, Couppié, Pierre, Sellier, Pierre, Grabar, Sophie
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.07.2025
Centers for Disease Control and Prevention
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - history
Analysis
Antiretroviral agents
Data warehouses
Disease
Diseases
Disseminated Histoplasmosis in Persons Living with HIV, France and Overseas Territories,1992–2021
Female
France - epidemiology
French Guiana - epidemiology
fungal infection
fungi
Health aspects
Highly active antiretroviral therapy
Histoplasma spp
Histoplasmosis
Histoplasmosis - epidemiology
Histoplasmosis - history
History, 21st Century
HIV
HIV (Viruses)
HIV Infections - complications
HIV Infections - epidemiology
HIV patients
HIV/AIDS and other retroviruses
Human immunodeficiency virus
Humans
Incidence
Infection
Male
Martinique - epidemiology
Medical prognosis
Middle Aged
Risk factors
Sexually transmitted diseases
Statistics
STD
French Guiana
France
Martinique
Guadeloupe
South America
Central America
Sub-Saharan Africa
Indian Ocean
United States > US
Asia
Africa
Reunion Island
North Africa
Americas
fungal infection
Asia
HIV/AIDS and other retroviruses
fungi
Africa
Histoplasma spp
histoplasmosis
Caribbean
France
incidence
global burden
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Summary:Disseminated histoplasmosis is a major issue among persons with advanced HIV in the Americas; it might also affect persons in sub-Saharan Africa, the Caribbean, and Asia and can be mistaken for other infections. By using 1992-2021 data from the French hospital database on HIV, we analyzed 198,798 persons with HIV follow-up in France and its overseas territories, identifying 553 (2.8/1,000 person-years) first episodes of disseminated histoplasmosis. Incidence rates varied by site of follow-up: 9.41 in French Guiana, 0.76 in Guadeloupe, 0.62 in Martinique, and 0.079 in mainland France. Incidence rates in France also varied between regions of origin or travel: 4.73 for Central or South America, 1.36 for the Caribbean, and 0.19 for sub-Saharan Africa or Asia. Differences persisted after adjusting for age, sex, CD4 count, and viral load at baseline. Overall, incidence and early death have declined, likely because of antiretroviral drug rollout in France.
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid3107.241931