HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy

We investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted intervention in the LEAP clinical trial. We identified an association between peanut-specific IgG4 and HLA-DQA1*01:02 that was only observed...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 132; no. 1
Main Authors:	Kanchan, Kanika, Grinek, Stepan, Bahnson, Henry T., Ruczinski, Ingo, Shankar, Gautam, Larson, David, Du Toit, George, Barnes, Kathleen C., Sampson, Hugh A., Suarez-Farinas, Mayte, Lack, Gideon, Nepom, Gerald T., Cerosaletti, Karen, Mathias, Rasika A.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.01.2022
Subjects:	2S Albumins, Plant - immunology Alleles Allelomorphism Antibody Formation - genetics Antibody Formation - immunology Antigens, Plant - immunology Arachis Child Female Genetic aspects Genetics Health aspects Histocompatibility antigens HLA histocompatibility antigens HLA-DQ alpha-Chains - genetics HLA-DQ alpha-Chains - immunology Humans Immune response Immunoglobulin G Immunoglobulin G - immunology Immunology Male Peanut allergy Peanut Hypersensitivity - genetics Peanut Hypersensitivity - immunology Prevention United States MHC class 1 Genetics Immunology MHC class 2 Genetic variation
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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