HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy

We investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted intervention in the LEAP clinical trial. We identified an association between peanut-specific IgG4 and HLA-DQA1*01:02 that was only observed...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:The Journal of clinical investigation Ročník 132; číslo 1
Hlavní autoři: Kanchan, Kanika, Grinek, Stepan, Bahnson, Henry T., Ruczinski, Ingo, Shankar, Gautam, Larson, David, Du Toit, George, Barnes, Kathleen C., Sampson, Hugh A., Suarez-Farinas, Mayte, Lack, Gideon, Nepom, Gerald T., Cerosaletti, Karen, Mathias, Rasika A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States American Society for Clinical Investigation 01.01.2022
Témata:
2S Albumins, Plant - immunology
Alleles
Allelomorphism
Antibody Formation - genetics
Antibody Formation - immunology
Antigens, Plant - immunology
Arachis
Child
Female
Genetic aspects
Genetics
Health aspects
Histocompatibility antigens
HLA histocompatibility antigens
HLA-DQ alpha-Chains - genetics
HLA-DQ alpha-Chains - immunology
Humans
Immune response
Immunoglobulin G
Immunoglobulin G - immunology
Immunology
Male
Peanut allergy
Peanut Hypersensitivity - genetics
Peanut Hypersensitivity - immunology
Prevention
United States
MHC class 1
Genetics
Immunology
MHC class 2
Genetic variation
ISSN:1558-8238, 0021-9738, 1558-8238
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:We investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted intervention in the LEAP clinical trial. We identified an association between peanut-specific IgG4 and HLA-DQA1*01:02 that was only observed in the presence of sustained oral peanut protein exposure. The association between IgG4 and HLA-DQA1*01:02 was driven by IgG4 specific for the Ara h 2 component. Once peanut consumption ceased, the association between IgG4-specific Ara h 2 and HLA-DQA1*01:02 was attenuated. The association was validated by observing expanded IgG4-specific epitopes in people who carried HLA-DQA1*01:02. Notably, we confirmed the previously reported associations with HLA-DQA1*01:02 and peanut allergy risk in the absence of oral peanut protein exposure. Interaction between HLA and presence or absence of exposure to peanut in an allergen- and epitope-specific manner implicates a mechanism of antigen recognition that is fundamental to driving immune responses related to allergy risk or protection.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
ISSN:1558-8238
0021-9738
1558-8238
DOI:10.1172/JCI152070