Microfluidic formulation of nanoparticles for biomedical applications

Nanomedicine has made significant advances in clinical applications since the late-20th century, in part due to its distinct advantages in biocompatibility, potency, and novel therapeutic applications. Many nanoparticle (NP) therapies have been approved for clinical use, including as imaging agents...

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Bibliographic Details
Published in:Biomaterials Vol. 274; p. 120826
Main Authors: Shepherd, Sarah J., Issadore, David, Mitchell, Michael J.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.07.2021
Subjects:
biocompatibility
biocompatible materials
Drug delivery
Drug Delivery Systems
drugs
gene therapy
Imaging
microfluidic technology
Microfluidics
Nanomedicine
Nanoparticle
Nanoparticles
Polymers
Drug delivery
Nanoparticle
Imaging
Microfluidics
ISSN:0142-9612, 1878-5905, 1878-5905
Online Access:Get full text
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Summary:Nanomedicine has made significant advances in clinical applications since the late-20th century, in part due to its distinct advantages in biocompatibility, potency, and novel therapeutic applications. Many nanoparticle (NP) therapies have been approved for clinical use, including as imaging agents or as platforms for drug delivery and gene therapy. However, there are remaining challenges that hinder translation, such as non-scalable production methods and the inefficiency of current NP formulations in delivering their cargo to their target. To address challenges with existing formulation methods that have batch-to-batch variability and produce particles with high dispersity, microfluidics—devices that manipulate fluids on a micrometer scale—have demonstrated enormous potential to generate reproducible NP formulations for therapeutic, diagnostic, and preventative applications. Microfluidic-generated NP formulations have been shown to have enhanced properties for biomedical applications by formulating NPs with more controlled physical properties than is possible with bulk techniques—such as size, size distribution, and loading efficiency. In this review, we highlight advances in microfluidic technologies for the formulation of NPs, with an emphasis on lipid-based NPs, polymeric NPs, and inorganic NPs. We provide a summary of microfluidic devices used for NP formulation with their advantages and respective challenges. Additionally, we provide our analysis for future outlooks in the field of NP formulation and microfluidics, with emerging topics of production scale-independent formulations through device parallelization and multi-step reactions within droplets.
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S.J.S. performed the literature search and designed the display items. S.J.S., D.I., and M.J.M. discussed the manuscript content and wrote the manuscript. All authors critically reviewed and edited the manuscript before submission.
Author contributions
ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2021.120826