Dangers of hyperoxia

Oxygen (O 2 ) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O 2 , i.e. inspiratory O 2 concentrations (F I O 2 ) > 0.21 may cause hyperoxaemia (i.e. arterial (a) PO 2 > 100 mmHg) and, subsequ...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 25; no. 1; pp. 440 - 15
Main Authors:	Singer, Mervyn, Young, Paul J., Laffey, John G., Asfar, Pierre, Taccone, Fabio Silvio, Skrifvars, Markus B., Meyhoff, Christian S., Radermacher, Peter
Format:	Journal Article
Language:	English
Published:	London BioMed Central 19.12.2021 BioMed Central Ltd BMC
Subjects:	ARDS Blood gases Critical Care Medicine Emergency Medicine Health aspects Humans Hyperoxaemia Hyperoxia Hyperoxia - complications Intensive Ischemia Lung Lung diseases Medicine Medicine & Public Health Oxygen Oxygen consumption Reactive nitrogen species Reactive Oxygen Species Review Risk factors Sepsis United Kingdom Myocardial infarction Reactive oxygen species Traumatic brain injury Reactive nitrogen species Acute ischaemic stroke Intracranial bleeding Subarachnoidal bleeding Hyperoxia Cardiopulmonary resuscitation Surgical site infection Hyperoxaemia Sepsis ARDS Trauma-and-haemorrhage
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X
Online Access:	Get full text
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Summary:	Oxygen (O 2 ) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O 2 , i.e. inspiratory O 2 concentrations (F I O 2 ) > 0.21 may cause hyperoxaemia (i.e. arterial (a) PO 2 > 100 mmHg) and, subsequently, hyperoxia (increased tissue O 2 concentration), thereby enhancing ROS formation. Here, we review the pathophysiology of O 2 toxicity and the potential harms of supplemental O 2 in various ICU conditions. The current evidence base suggests that PaO 2 > 300 mmHg (40 kPa) should be avoided, but it remains uncertain whether there is an “optimal level” which may vary for given clinical conditions. Since even moderately supra-physiological PaO 2 may be associated with deleterious side effects, it seems advisable at present to titrate O 2 to maintain PaO 2 within the normal range, avoiding both hypoxaemia and excess hyperoxaemia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1364-8535 1466-609X 1364-8535 1466-609X
DOI:	10.1186/s13054-021-03815-y