Dangers of hyperoxia
Oxygen (O 2 ) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O 2 , i.e. inspiratory O 2 concentrations (F I O 2 ) > 0.21 may cause hyperoxaemia (i.e. arterial (a) PO 2 > 100 mmHg) and, subsequ...
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| Vydané v: | Critical care (London, England) Ročník 25; číslo 1; s. 440 - 15 |
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| Hlavní autori: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
London
BioMed Central
19.12.2021
BioMed Central Ltd BMC |
| Predmet: | |
| ISSN: | 1364-8535, 1466-609X, 1364-8535, 1466-609X |
| On-line prístup: | Získať plný text |
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| Shrnutí: | Oxygen (O
2
) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS).
Supplemental O
2
, i.e. inspiratory O
2
concentrations (F
I
O
2
) > 0.21 may cause
hyperoxaemia
(i.e. arterial (a) PO
2
> 100 mmHg) and, subsequently,
hyperoxia
(increased tissue O
2
concentration), thereby enhancing ROS formation. Here, we review the pathophysiology of O
2
toxicity and the potential harms of supplemental O
2
in various ICU conditions. The current evidence base suggests that PaO
2
> 300 mmHg (40 kPa) should be avoided, but it remains uncertain whether there is an “optimal level” which may vary for given clinical conditions. Since even moderately supra-physiological PaO
2
may be associated with deleterious side effects, it seems advisable at present to titrate O
2
to maintain PaO
2
within the normal range, avoiding both hypoxaemia and excess hyperoxaemia. |
|---|---|
| Bibliografia: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ISSN: | 1364-8535 1466-609X 1364-8535 1466-609X |
| DOI: | 10.1186/s13054-021-03815-y |