Spike substitutions E484D, P812R and Q954H mediate ACE2-independent entry of SARS-CoV-2 across different cell lines

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has evolved into variants with multiple spike protein coding mutations that affect its transmissibility, infectivity, and immune evasion, in particular from neutralizing antibodies. Severa...

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Bibliographic Details
Published in:	PloS one Vol. 20; no. 8; p. e0326419
Main Authors:	Vizgirda, Greta, Underwood, Alexander P., Fahnøe, Ulrik, Weis, Nina, Ramirez, Santseharay, Bukh, Jens
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.08.2025 Public Library of Science (PLoS)
Subjects:	A549 Cells ACE2 Adaptation Amino acid sequence Amino Acid Substitution Amino acids Analysis Angiotensin Angiotensin converting enzyme Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - genetics Angiotensin-Converting Enzyme 2 - metabolism Animals Antibodies, Neutralizing - immunology Biology and life sciences Cell culture Cell Line Cell lines Chlorocebus aethiops Coronaviruses COVID-19 COVID-19 - virology Deletion Disease transmission Enzymes Health aspects Hepatitis C Hepatocytes Humans Infections Infectivity Leukemia Medicine and health sciences Mutagenesis Mutation Neutralization Peptidyl-dipeptidase A Physical Sciences Plasmids Proteins Receptors SARS-CoV-2 - genetics SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism Spike protein Vero Cells Viral diseases Viral proteins Virus Internalization Viruses Denmark United Kingdom > UK England
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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