Multimodality imaging characteristics of dementia with Lewy bodies

Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia after Alzheimer's disease (AD). Our objective was to determine whether the 11C-Pittsburgh Compound-B (PiB) retention and regional hypometabolism on positron emission tomography (PET) and regional corti...

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Veröffentlicht in:Neurobiology of aging Jg. 33; H. 9; S. 2091 - 2105
Hauptverfasser: Kantarci, Kejal, Lowe, Val J., Boeve, Bradley F., Weigand, Stephen D., Senjem, Matthew L., Przybelski, Scott A., Dickson, Dennis W., Parisi, Joseph E., Knopman, David S., Smith, Glenn E., Ferman, Tanis J., Petersen, Ronald C., Jack, Clifford R.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.09.2012
Schlagworte:
Aged
Aged, 80 and over
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - pathology
Alzheimer's disease
Aniline Compounds
Brain Mapping
Case-Control Studies
Dementia with Lewy bodies
FDG
Female
Fluorodeoxyglucose F18
Humans
Imaging, Three-Dimensional
Internal Medicine
Lewy Body Disease - diagnostic imaging
Lewy Body Disease - pathology
Magnetic Resonance Imaging
Male
Middle Aged
MRI
Neurology
Occipital Lobe - diagnostic imaging
PET
PiB
Positron-Emission Tomography
ROC Curve
Statistics, Nonparametric
Thiazoles
FDG
PiB
MRI
Alzheimer's disease
PET
Dementia with Lewy bodies
ISSN:0197-4580, 1558-1497, 1558-1497
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Zusammenfassung:Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia after Alzheimer's disease (AD). Our objective was to determine whether the 11C-Pittsburgh Compound-B (PiB) retention and regional hypometabolism on positron emission tomography (PET) and regional cortical atrophy on magnetic resonance imaging (MRI) are complementary in characterizing patients with DLB and differentiating them from AD. We studied age-, gender-, and education-matched patients with a clinical diagnosis of DLB (n = 21), AD (n = 21), and cognitively normal subjects (n = 42). Hippocampal atrophy, global cortical PiB retention and occipital lobe metabolism in combination distinguished DLB from AD better than any of the measurements alone (area under the receiver operating characteristic = 0.98). Five of the DLB and AD patients who underwent autopsy were distinguished through multimodality imaging. These data demonstrate that magnetic resonance imaging and PiB positron emission tomography contribute to characterizing the distinct pathological mechanisms in patients with AD compared with DLB. Occipital and posterior parietotemporal lobe hypometabolism is a distinguishing feature of DLB and this regional hypometabolic pattern is independent of the amyloid pathology.
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ISSN:0197-4580
1558-1497
1558-1497
DOI:10.1016/j.neurobiolaging.2011.09.024