Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylat...
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| Published in: | Nature communications Vol. 10; no. 1; pp. 3924 - 14 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
Nature Publishing Group UK
02.09.2019
Nature Publishing Group Nature Portfolio |
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| ISSN: | 2041-1723, 2041-1723 |
| Online Access: | Get full text |
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| Abstract | The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylation and consequently signaling functions of 5-HT1AR. Two rodent models for depression-like behavior show reduced brain ZDHHC21 expression and attenuated 5-HT1AR palmitoylation. Moreover, selective knock-down of ZDHHC21 in the murine forebrain induced depression-like behavior. We also identified the microRNA miR-30e as a negative regulator of
Zdhhc21
expression. Through analysis of the post-mortem brain samples in individuals with MDD that died by suicide we find that miR-30e expression is increased, while ZDHHC21 expression, as well as palmitoylation of 5-HT1AR, are reduced within the prefrontal cortex. Our study suggests that downregulation of 5-HT1AR palmitoylation is a mechanism involved in depression, making the restoration of 5-HT1AR palmitoylation a promising clinical strategy for the treatment of MDD.
Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder. |
|---|---|
| AbstractList | Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder. The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylation and consequently signaling functions of 5-HT1AR. Two rodent models for depression-like behavior show reduced brain ZDHHC21 expression and attenuated 5-HT1AR palmitoylation. Moreover, selective knock-down of ZDHHC21 in the murine forebrain induced depression-like behavior. We also identified the microRNA miR-30e as a negative regulator of Zdhhc21 expression. Through analysis of the post-mortem brain samples in individuals with MDD that died by suicide we find that miR-30e expression is increased, while ZDHHC21 expression, as well as palmitoylation of 5-HT1AR, are reduced within the prefrontal cortex. Our study suggests that downregulation of 5-HT1AR palmitoylation is a mechanism involved in depression, making the restoration of 5-HT1AR palmitoylation a promising clinical strategy for the treatment of MDD. Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder. The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylation and consequently signaling functions of 5-HT1AR. Two rodent models for depression-like behavior show reduced brain ZDHHC21 expression and attenuated 5-HT1AR palmitoylation. Moreover, selective knock-down of ZDHHC21 in the murine forebrain induced depression-like behavior. We also identified the microRNA miR-30e as a negative regulator of Zdhhc21 expression. Through analysis of the post-mortem brain samples in individuals with MDD that died by suicide we find that miR-30e expression is increased, while ZDHHC21 expression, as well as palmitoylation of 5-HT1AR, are reduced within the prefrontal cortex. Our study suggests that downregulation of 5-HT1AR palmitoylation is a mechanism involved in depression, making the restoration of 5-HT1AR palmitoylation a promising clinical strategy for the treatment of MDD. Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder. The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylation and consequently signaling functions of 5-HT1AR. Two rodent models for depression-like behavior show reduced brain ZDHHC21 expression and attenuated 5-HT1AR palmitoylation. Moreover, selective knock-down of ZDHHC21 in the murine forebrain induced depression-like behavior. We also identified the microRNA miR-30e as a negative regulator of Zdhhc21 expression. Through analysis of the post-mortem brain samples in individuals with MDD that died by suicide we find that miR-30e expression is increased, while ZDHHC21 expression, as well as palmitoylation of 5-HT1AR, are reduced within the prefrontal cortex. Our study suggests that downregulation of 5-HT1AR palmitoylation is a mechanism involved in depression, making the restoration of 5-HT1AR palmitoylation a promising clinical strategy for the treatment of MDD. The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylation and consequently signaling functions of 5-HT1AR. Two rodent models for depression-like behavior show reduced brain ZDHHC21 expression and attenuated 5-HT1AR palmitoylation. Moreover, selective knock-down of ZDHHC21 in the murine forebrain induced depression-like behavior. We also identified the microRNA miR-30e as a negative regulator of Zdhhc21 expression. Through analysis of the post-mortem brain samples in individuals with MDD that died by suicide we find that miR-30e expression is increased, while ZDHHC21 expression, as well as palmitoylation of 5-HT1AR, are reduced within the prefrontal cortex. Our study suggests that downregulation of 5-HT1AR palmitoylation is a mechanism involved in depression, making the restoration of 5-HT1AR palmitoylation a promising clinical strategy for the treatment of MDD. The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylation and consequently signaling functions of 5-HT1AR. Two rodent models for depression-like behavior show reduced brain ZDHHC21 expression and attenuated 5-HT1AR palmitoylation. Moreover, selective knock-down of ZDHHC21 in the murine forebrain induced depression-like behavior. We also identified the microRNA miR-30e as a negative regulator of Zdhhc21 expression. Through analysis of the post-mortem brain samples in individuals with MDD that died by suicide we find that miR-30e expression is increased, while ZDHHC21 expression, as well as palmitoylation of 5-HT1AR, are reduced within the prefrontal cortex. Our study suggests that downregulation of 5-HT1AR palmitoylation is a mechanism involved in depression, making the restoration of 5-HT1AR palmitoylation a promising clinical strategy for the treatment of MDD. The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylation and consequently signaling functions of 5-HT1AR. Two rodent models for depression-like behavior show reduced brain ZDHHC21 expression and attenuated 5-HT1AR palmitoylation. Moreover, selective knock-down of ZDHHC21 in the murine forebrain induced depression-like behavior. We also identified the microRNA miR-30e as a negative regulator of Zdhhc21 expression. Through analysis of the post-mortem brain samples in individuals with MDD that died by suicide we find that miR-30e expression is increased, while ZDHHC21 expression, as well as palmitoylation of 5-HT1AR, are reduced within the prefrontal cortex. Our study suggests that downregulation of 5-HT1AR palmitoylation is a mechanism involved in depression, making the restoration of 5-HT1AR palmitoylation a promising clinical strategy for the treatment of MDD.The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylation and consequently signaling functions of 5-HT1AR. Two rodent models for depression-like behavior show reduced brain ZDHHC21 expression and attenuated 5-HT1AR palmitoylation. Moreover, selective knock-down of ZDHHC21 in the murine forebrain induced depression-like behavior. We also identified the microRNA miR-30e as a negative regulator of Zdhhc21 expression. Through analysis of the post-mortem brain samples in individuals with MDD that died by suicide we find that miR-30e expression is increased, while ZDHHC21 expression, as well as palmitoylation of 5-HT1AR, are reduced within the prefrontal cortex. Our study suggests that downregulation of 5-HT1AR palmitoylation is a mechanism involved in depression, making the restoration of 5-HT1AR palmitoylation a promising clinical strategy for the treatment of MDD. |
| ArticleNumber | 3924 |
| Author | Papaleo, Francesco Scheggia, Diego Smyth, Ian Zeug, Andre Ilchibaeva, Tatiana Sigrist, Stephan Krzystyniak, Adam Hobuß, Lisa Bijata, Monika Ponimaskin, Evgeni Prasad, Sonal Kondaurova, Elena Gorinski, Nataliya Zareba-Koziol, Monika Fiedler, Jan Thum, Thomas Pandey, Ghanshyam Wlodarczyk, Jakub Bazovkina, Daria Kulikova, Elizabeth Kochlamazashvili, Gaga Abdel Galil, Dalia Richter, Diethelm W. Bang, Claudia Naumenko, Vladimir S. Dityatev, Alexander Wirth, Alexander Strekalova, Tatyana |
| Author_xml | – sequence: 1 givenname: Nataliya orcidid: 0000-0002-5606-7162 surname: Gorinski fullname: Gorinski, Nataliya organization: Cellular Neurophysiology, Hannover Medical School – sequence: 2 givenname: Monika surname: Bijata fullname: Bijata, Monika organization: Cellular Neurophysiology, Hannover Medical School, Cell Biophysics, Nencki Institute – sequence: 3 givenname: Sonal surname: Prasad fullname: Prasad, Sonal organization: Cellular Neurophysiology, Hannover Medical School – sequence: 4 givenname: Alexander surname: Wirth fullname: Wirth, Alexander organization: Cellular Neurophysiology, Hannover Medical School – sequence: 5 givenname: Dalia surname: Abdel Galil fullname: Abdel Galil, Dalia organization: Cellular Neurophysiology, Hannover Medical School – sequence: 6 givenname: Andre orcidid: 0000-0001-9858-5841 surname: Zeug fullname: Zeug, Andre organization: Cellular Neurophysiology, Hannover Medical School – sequence: 7 givenname: Daria surname: Bazovkina fullname: Bazovkina, Daria organization: Behavioural Neurogenomics, Institute of Cytology and Genetics – sequence: 8 givenname: Elena surname: Kondaurova fullname: Kondaurova, Elena organization: Behavioural Neurogenomics, Institute of Cytology and Genetics – sequence: 9 givenname: Elizabeth surname: Kulikova fullname: Kulikova, Elizabeth organization: Behavioural Neurogenomics, Institute of Cytology and Genetics – sequence: 10 givenname: Tatiana surname: Ilchibaeva fullname: Ilchibaeva, Tatiana organization: Behavioural Neurogenomics, Institute of Cytology and Genetics – sequence: 11 givenname: Monika orcidid: 0000-0003-3544-6259 surname: Zareba-Koziol fullname: Zareba-Koziol, Monika organization: Cell Biophysics, Nencki Institute – sequence: 12 givenname: Francesco orcidid: 0000-0002-6326-0657 surname: Papaleo fullname: Papaleo, Francesco organization: Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia – sequence: 13 givenname: Diego orcidid: 0000-0003-2586-9717 surname: Scheggia fullname: Scheggia, Diego organization: Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia – sequence: 14 givenname: Gaga surname: Kochlamazashvili fullname: Kochlamazashvili, Gaga organization: Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia – sequence: 15 givenname: Alexander orcidid: 0000-0002-0472-0553 surname: Dityatev fullname: Dityatev, Alexander organization: Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Molecular Neuroplasticity, DZNE – sequence: 16 givenname: Ian surname: Smyth fullname: Smyth, Ian organization: Anatomy & Developmental Biology, Monash University – sequence: 17 givenname: Adam surname: Krzystyniak fullname: Krzystyniak, Adam organization: Cell Biophysics, Nencki Institute – sequence: 18 givenname: Jakub surname: Wlodarczyk fullname: Wlodarczyk, Jakub organization: Cell Biophysics, Nencki Institute – sequence: 19 givenname: Diethelm W. surname: Richter fullname: Richter, Diethelm W. organization: Neuro and Sensory Physiology, University of Göttingen – sequence: 20 givenname: Tatyana surname: Strekalova fullname: Strekalova, Tatyana organization: Sechenov First Moscow State Medical University, Neuroscience, Maastricht University, Laboratory of Psychiatric Neurobiology and Institute of General Pathology and Pathophysiology, Sechenov First Moscow State Medical University – sequence: 21 givenname: Stephan surname: Sigrist fullname: Sigrist, Stephan organization: Institute of Biology, Free University Berlin – sequence: 22 givenname: Claudia surname: Bang fullname: Bang, Claudia organization: Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School – sequence: 23 givenname: Lisa surname: Hobuß fullname: Hobuß, Lisa organization: Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School – sequence: 24 givenname: Jan surname: Fiedler fullname: Fiedler, Jan organization: Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School – sequence: 25 givenname: Thomas orcidid: 0000-0003-4360-1511 surname: Thum fullname: Thum, Thomas organization: Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School – sequence: 26 givenname: Vladimir S. surname: Naumenko fullname: Naumenko, Vladimir S. email: naumenko2002@mail.ru organization: Behavioural Neurogenomics, Institute of Cytology and Genetics – sequence: 27 givenname: Ghanshyam surname: Pandey fullname: Pandey, Ghanshyam email: GPandey@psych.uic.edu organization: Department of Psychiatry, University of Illinois – sequence: 28 givenname: Evgeni orcidid: 0000-0002-4570-5130 surname: Ponimaskin fullname: Ponimaskin, Evgeni email: Ponimaskin.evgeni@mh-hannover.de organization: Cellular Neurophysiology, Hannover Medical School |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31477731$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-161244$$DView record from Swedish Publication Index (Linköpings universitet) |
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| Cites_doi | 10.1016/j.pneurobio.2016.03.007 10.1016/j.biopsych.2005.10.025 10.1074/jbc.M308177200 10.1016/j.bbi.2012.12.017 10.1016/j.molcel.2007.12.010 10.1016/j.jpsychires.2010.04.028 10.1016/j.biopsych.2003.09.017 10.1097/00008877-200505000-00006 10.1242/jcs.101337 10.1042/BST20140235 10.1073/pnas.1317528110 10.1038/416396a 10.1007/s002130100687 10.1016/j.bbr.2009.11.012 10.1016/j.ejphar.2003.09.064 10.1038/nature05453 10.1038/onc.2011.453 10.1016/j.bbalip.2006.03.010 10.1016/j.cell.2009.01.002 10.1002/ijc.2910570708 10.1016/j.pbb.2014.04.003 10.1038/sj.npp.1300532 10.1016/j.neuron.2004.12.005 10.1186/gb-2007-8-2-r27 10.1371/journal.pgen.1000748 10.1128/MCB.00144-16 10.1074/jbc.M111.306183 10.1016/j.celrep.2017.05.023 10.1038/nn.3657 10.1016/j.neuron.2011.11.021 10.1016/j.jprot.2012.05.030 10.1002/ajmg.1320600509 10.1016/S0969-8051(00)00119-0 10.1016/j.neubiorev.2009.05.004 10.1038/npp.2016.175 10.1042/BJ20130788 10.1074/mcp.RA117.000050 10.1038/nm.3582 10.1523/JNEUROSCI.22-16-07154.2002 10.1016/j.conb.2017.02.016 10.1523/JNEUROSCI.0091-07.2007 10.1038/nmeth.2250 10.1038/266730a0 10.1016/j.biopsych.2005.06.016 10.1016/S0306-4522(97)00233-9 10.1007/s12031-009-9252-1 10.1016/j.jneumeth.2008.01.024 10.1016/j.ejphar.2010.02.016 10.1523/JNEUROSCI.0419-16.2016 10.1016/j.neuroscience.2003.12.024 10.1523/JNEUROSCI.18-18-07394.1998 10.1038/npp.2009.54 10.1038/nrn2788 10.1016/j.jad.2010.05.019 10.1016/j.celrep.2018.12.022 10.1186/1471-2202-13-110 10.1038/sj.npp.1300774 10.1523/JNEUROSCI.1436-10.2010 10.1073/pnas.0511041103 10.1097/00041444-199906000-00010 10.1016/B978-0-12-408143-7.00014-1 10.1073/pnas.95.18.10734 10.1016/0006-3223(94)91213-0 10.1038/nature23887 10.7554/eLife.11306 10.1124/mol.107.037085 10.1001/archpsyc.57.2.174 10.1038/sj.npp.1300992 10.1017/S1461145707008140 10.1073/pnas.1413627111 10.1074/jbc.M111.236869 10.1002/(SICI)1096-8628(19980907)81:5<434::AID-AJMG13>3.0.CO;2-D 10.1016/j.schres.2010.07.002 10.1016/j.jad.2016.01.017 10.1007/978-1-4939-0685-7_14 10.1016/j.bbr.2014.04.037 10.1016/j.bcp.2003.09.030 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2019 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| References | ClineBHLasting downregulation of the lipid peroxidation enzymes in the prefrontal cortex of mice susceptible to stress-induced anhedoniaBehav. Brain Res.20152761181291:CAS:528:DC%2BC2cXotFOrtr0%3D10.1016/j.bbr.2014.04.037 ConacoCOttoSHanJ-JMandelGReciprocal actions of REST and a microRNA promote neuronal identityProc. Natl Acad. Sci. USA2006103242224271:CAS:528:DC%2BD28XhslGjtLo%3D10.1073/pnas.05110411032006PNAS..103.2422C ThomasGMHayashiTChiuS-LChenC-MHuganirRLPalmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R traffickingNeuron2012734824961:CAS:528:DC%2BC38XitFOjtb4%3D10.1016/j.neuron.2011.11.021 OttoSJA new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functionsJ. Neurosci.200727672967391:CAS:528:DC%2BD2sXnsVWqs7s%3D10.1523/JNEUROSCI.0091-07.2007 MillPPalmitoylation regulates epidermal homeostasis and hair follicle differentiationPLoS Genet.20095e100074810.1371/journal.pgen.1000748 RinaldiAStress induces region specific alterations in microRNAs expression in miceBehav. Brain Res.20102082652691:CAS:528:DC%2BC3cXhs1altrY%3D10.1016/j.bbr.2009.11.012 BartelDPMicroRNA target recognition and regulatory functionsCell20091362152331:CAS:528:DC%2BD1MXhs1Kiuro%3D10.1016/j.cell.2009.01.002 MeersonAChanges in brain MicroRNAs contribute to cholinergic stress reactionsJ. Mol. Neurosci.20104047551:CAS:528:DC%2BC3cXmvFSrtA%3D%3D10.1007/s12031-009-9252-1 SobocińskaJLipopolysaccharide upregulates palmitoylated enzymes of the phosphatidylinositol cycle: an insight from proteomic studiesMol. Cell. Proteomics20181723325410.1074/mcp.RA117.000050 MayorgaAJLuckiILimitations on the use of the C57BL/6 mouse in the tail suspension testPsychopharmacology (Berl.)20011551101121:CAS:528:DC%2BD3MXjslCrtLc%3D10.1007/s002130100687 BijataMSynaptic remodeling depends on signaling between serotonin receptors and the extracellular matrixCell Rep.201719176717821:CAS:528:DC%2BC2sXptVWlt7g%3D10.1016/j.celrep.2017.05.023 MalinowskaADiffprot - software for non-parametric statistical analysis of differential proteomics dataJ. Proteomics201275406240731:CAS:528:DC%2BC38XosVarsbY%3D10.1016/j.jprot.2012.05.030 SalonikidisPSAn ion-insensitive cAMP biosensor for long term quantitative ratiometric fluorescence resonance energy transfer (FRET) measurements under variable physiological conditionsJ. Biol. Chem.201128623419234311:CAS:528:DC%2BC3MXnvFersbs%3D10.1074/jbc.M111.236869 StockmeierCAIncrease in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activityJ. Neurosci.199818739474011:CAS:528:DyaK1cXmt1Sjtbs%3D10.1523/JNEUROSCI.18-18-07394.1998 RennerUHeterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and traffickingJ. Cell Sci.2012125248624991:CAS:528:DC%2BC38XhtFehurvN10.1242/jcs.1013372012dfpb.book.....R ParseyRVAltered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography studyBiol. Psychiatry2006591061131:CAS:528:DC%2BD28XotVGksg%3D%3D10.1016/j.biopsych.2005.06.016 ParksCLRobinsonPSSibilleEShenkTTothMIncreased anxiety of mice lacking the serotonin1A receptorProc. Natl Acad. Sci. USA19989510734107391:CAS:528:DyaK1cXlvFWgsbY%3D10.1073/pnas.95.18.107341998PNAS...9510734P WirthADual lipidation of the brain-specific Cdc42 isoform regulates its functional propertiesBiochem. J.20134563113221:CAS:528:DC%2BC3sXhvVartr%2FI10.1042/BJ20130788 SugimotoYAntidepressant-like effects of neferine in the forced swimming test involve the serotonin1A (5-HT1A) receptor in miceEur. J. Pharmacol.201063462671:CAS:528:DC%2BC3cXks1Wmt7Y%3D10.1016/j.ejphar.2010.02.016 SchepelerTAttenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genesOncogene201231275027601:CAS:528:DC%2BC3MXht1GqsL3I10.1038/onc.2011.453 PorsoltRDLe PichonMJalfreMDepression: a new animal model sensitive to antidepressant treatmentsNature19772667307321:CAS:528:DyaE2sXkvFGhur4%3D10.1038/266730a01977Natur.266..730P LeinESGenome-wide atlas of gene expression in the adult mouse brainNature20074451681761:CAS:528:DC%2BD2sXjtFKjtw%3D%3D10.1038/nature054532007Natur.445..168L Prasad, S., Zeug, A. & Ponimaskin, E. Analysis of receptor–receptor interaction by combined application of FRET and microscopy. Methods Cell Biol.117, 243–265 (2013). López-FigueroaALSerotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophreniaBiol. Psychiatry20045522523310.1016/j.biopsych.2003.09.017 CouchYMicroglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedoniaBrain. Behav. Immun.2013291361461:CAS:528:DC%2BC3sXhvFahs7g%3D10.1016/j.bbi.2012.12.017 KulikovAVTikhonovaMAKulikovVAAutomated measurement of spatial preference in the open field test with transmitted lightingJ. Neurosci. Methods200817034535110.1016/j.jneumeth.2008.01.024 DellingMThe neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid raftsJ. Neurosci.200222715471641:CAS:528:DC%2BD38XmsF2gsb8%3D10.1523/JNEUROSCI.22-16-07154.2002 WirthAHolstKPonimaskinEHow serotonin receptors regulate morphogenic signalling in neuronsProg. Neurobiol.201715135561:CAS:528:DC%2BC28XltVKksr4%3D10.1016/j.pneurobio.2016.03.007 GlobaAKBamjiSXProtein palmitoylation in the development and plasticity of neuronal connectionsCurr. Opin. Neurobiol.2017452102201:CAS:528:DC%2BC2sXkvF2hsbY%3D10.1016/j.conb.2017.02.016 KimAHMicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disordersSchizophr. Res.201012418319110.1016/j.schres.2010.07.002 XuYA polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveformJ. Affect. Disord.20101273323361:CAS:528:DC%2BC3cXhtlyksbnO10.1016/j.jad.2010.05.019 KitrakiEKremmydaOYoulatosDAlexisMNKittasCGender-dependent alterations in corticosteroid receptor status and spatial performance following 21 days of restraint stressNeuroscience200412547551:CAS:528:DC%2BD2cXisFylsrc%3D10.1016/j.neuroscience.2003.12.024 BuynitskyTMostofskyDIRestraint stress in biobehavioral research: Recent developmentsNeurosci. Biobehav. Rev.2009331089109810.1016/j.neubiorev.2009.05.004 StrekalovaTSpanagelRDolgovOBartschDStress-induced hyperlocomotion as a confounding factor in anxiety and depression models in miceBehav. Pharmacol.2005161711801:STN:280:DC%2BD2M3islKitQ%3D%3D10.1097/00008877-200505000-00006 RongHMicroRNA-134 plasma levels before and after treatment for bipolar maniaJ. Psychiatr. Res.201145929510.1016/j.jpsychires.2010.04.028 ParseyRVHigher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic studyNeuropsychopharmacology200631174517491:CAS:528:DC%2BD28XmvFCntbc%3D10.1038/sj.npp.1300992 GrossCSerotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adultNature20024163964001:CAS:528:DC%2BD38XislantLo%3D10.1038/416396a2002Natur.416..396G PerkinsDOmicroRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorderGenome Biol.2007810.1186/gb-2007-8-2-r27 LinDTSConibearEEnzymatic protein depalmitoylation by acyl protein thioesterasesBiochem. Soc. Trans.2015431931981:CAS:528:DC%2BC2MXlvFSjtr4%3D10.1042/BST20140235 First, M. B., Williams, J. B. W., Spitzer, R. L. & Gibbon, M. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) (American Psychiatric Publications, 1997). GHO | World Health Statistics data visualizations dashboard | Suicide. WHO. Available at http://apps.who.int/gho/data/node.sdg.3-4-viz-2?lang=en. Accessed 15 May 2018 SargentPABrain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatmentArch. Gen. Psychiatry2000571741801:CAS:528:DC%2BD3cXhtFyqsrs%3D10.1001/archpsyc.57.2.174 LinDTSConibearEABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localizationeLife20154e1130610.7554/eLife.11306 KawanishiYHaradaSTachikawaHOkuboTShiraishiHNovel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophreniaAm. J. Med. Genet.1998814344391:STN:280:DyaK1cvisFKjsw%3D%3D10.1002/(SICI)1096-8628(19980907)81:5<434::AID-AJMG13>3.0.CO;2-D ChaiSCambronneXAEichhornSWGoodmanRHMicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9Proc. Natl Acad. Sci. USA201311017898179031:CAS:528:DC%2BC3sXhvVWmur%2FM10.1073/pnas.13175281102013PNAS..11017898C LopezJPmiR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatmentNat. Med.2014207647681:CAS:528:DC%2BC2cXpsVamtr0%3D10.1038/nm.3582 UchidaSEarly life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodentsJ. Neurosci.20103015007150181:CAS:528:DC%2BC3cXhsV2nurjO10.1523/JNEUROSCI.1436-10.2010 BrigidiGSPalmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticityNat. Neurosci.2014175225321:CAS:528:DC%2BC2cXivFahsr8%3D10.1038/nn.3657 FonslowBRDigestion and depletion of abundant proteins improves proteomic coverageNat. Methods20131054561:CAS:528:DC%2BC38Xhs1ymt7bF10.1038/nmeth.2250 Gerardy-SchahnREckhardtMHot spots of antigenicity in the neural cell adhesion molecule NCAMInt. J. Cancer Suppl.1994838421:CAS:528:DyaK28XmvVKqsA%3D%3D10.1002/ijc.2910570708 ChenSPalmitoylation-dependent activation of MC1R prevents melanomagenesisNature20175493994031:CAS:528:DC%2BC2sXhsVersrfI10.1038/nature238872017Natur.549..399C WangJDHHC4 and DHHC5 facilitate fatty ac A Wirth (11876_CR14) 2013; 456 M Bijata (11876_CR74) 2017; 19 KC Klemenhagen (11876_CR5) 2006; 31 A Miyake (11876_CR34) 2014; 122 PA Sargent (11876_CR37) 2000; 57 AL López-Figueroa (11876_CR38) 2004; 55 A Malinowska (11876_CR79) 2012; 75 DTS Lin (11876_CR24) 2015; 43 CL Parks (11876_CR8) 1998; 95 GS Brigidi (11876_CR48) 2014; 17 AJ Mayorga (11876_CR30) 2001; 155 N Sun (11876_CR58) 2016; 194 S Uchida (11876_CR64) 2010; 30 DTS Lin (11876_CR25) 2015; 4 AL Del Tredici (11876_CR45) 2004; 67 A Rinaldi (11876_CR63) 2010; 208 B Roy (11876_CR57) 2017; 42 R Gerardy-Schahn (11876_CR75) 1994; 8 S Chai (11876_CR36) 2013; 110 Y Fukata (11876_CR46) 2010; 11 DO Perkins (11876_CR60) 2007; 8 E Papoucheva (11876_CR12) 2003; 279 T Strekalova (11876_CR19) 2004; 29 T Buynitsky (11876_CR69) 2009; 33 S Wu (11876_CR4) 1999; 9 JM Miller (11876_CR42) 2009; 34 JP Lopez (11876_CR56) 2014; 20 U Renner (11876_CR13) 2007; 72 M Fukata (11876_CR76) 2004; 44 CA Stockmeier (11876_CR39) 1998; 18 G Wagner (11876_CR23) 2006; 59 J Wang (11876_CR52) 2019; 26 Y Li (11876_CR49) 2012; 287 AH Kim (11876_CR55) 2010; 124 11876_CR77 11876_CR78 C Gross (11876_CR6) 2002; 416 J Howie (11876_CR50) 2014; 111 U Renner (11876_CR11) 2012; 125 ES Lein (11876_CR27) 2007; 445 AK Globa (11876_CR28) 2017; 45 Y Sugimoto (11876_CR33) 2010; 634 A Wirth (11876_CR9) 2017; 151 Y Ohno (11876_CR15) 2006; 1761 M Delling (11876_CR10) 2002; 22 L Wu (11876_CR35) 2008; 29 C Conaco (11876_CR65) 2006; 103 RV Parsey (11876_CR40) 2006; 31 Y Kawanishi (11876_CR44) 1998; 81 Y Couch (11876_CR71) 2013; 29 H Rong (11876_CR54) 2011; 45 BR Fonslow (11876_CR32) 2013; 10 L Arike (11876_CR80) 2014; 1156 LA Galea (11876_CR68) 1997; 81 T Strekalova (11876_CR72) 2005; 16 BH Cline (11876_CR20) 2012; 13 F Biver (11876_CR22) 1994; 36 GM Thomas (11876_CR47) 2012; 73 AV Kulikov (11876_CR73) 2008; 170 11876_CR1 WC Drevets (11876_CR2) 2000; 27 11876_CR67 PS Salonikidis (11876_CR18) 2011; 286 PM-J Lievens (11876_CR17) 2016; 36 RD Porsolt (11876_CR70) 1977; 266 N Yokoi (11876_CR26) 2016; 36 RV Parsey (11876_CR41) 2006; 59 S Chen (11876_CR51) 2017; 549 J Hirvonen (11876_CR3) 2008; 11 SJ Otto (11876_CR66) 2007; 27 M Barros (11876_CR7) 2003; 482 J Erdmann (11876_CR43) 1995; 60 J Sobocińska (11876_CR31) 2018; 17 BH Cline (11876_CR21) 2015; 276 A Meerson (11876_CR62) 2010; 40 T Schepeler (11876_CR61) 2012; 31 P Mill (11876_CR16) 2009; 5 E Kitraki (11876_CR29) 2004; 125 DP Bartel (11876_CR53) 2009; 136 Y Xu (11876_CR59) 2010; 127 |
| References_xml | – reference: LinDTSConibearEABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localizationeLife20154e1130610.7554/eLife.11306 – reference: HowieJSubstrate recognition by the cell surface palmitoyl transferase DHHC5Proc. Natl Acad. Sci. USA201411117534175391:CAS:528:DC%2BC2cXhvFKmurfL10.1073/pnas.14136271112014PNAS..11117534H – reference: López-FigueroaALSerotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophreniaBiol. Psychiatry20045522523310.1016/j.biopsych.2003.09.017 – reference: FukataYFukataMProtein palmitoylation in neuronal development and synaptic plasticityNat. Rev. Neurosci.2010111611751:CAS:528:DC%2BC3cXitFemsbc%3D10.1038/nrn2788 – reference: FukataMFukataYAdesnikHNicollRABredtDSIdentification of PSD-95 palmitoylating enzymesNeuron2004449879961:CAS:528:DC%2BD2MXhsFejtw%3D%3D10.1016/j.neuron.2004.12.005 – reference: LievensPM-JZDHHC3 tyrosine phosphorylation regulates neural cell adhesion molecule palmitoylationMol. Cell. Biol.201636220822251:CAS:528:DC%2BC28XhslyrsL%2FO10.1128/MCB.00144-16 – reference: ThomasGMHayashiTChiuS-LChenC-MHuganirRLPalmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R traffickingNeuron2012734824961:CAS:528:DC%2BC38XitFOjtb4%3D10.1016/j.neuron.2011.11.021 – reference: WirthADual lipidation of the brain-specific Cdc42 isoform regulates its functional propertiesBiochem. J.20134563113221:CAS:528:DC%2BC3sXhvVartr%2FI10.1042/BJ20130788 – reference: KawanishiYHaradaSTachikawaHOkuboTShiraishiHNovel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophreniaAm. J. Med. Genet.1998814344391:STN:280:DyaK1cvisFKjsw%3D%3D10.1002/(SICI)1096-8628(19980907)81:5<434::AID-AJMG13>3.0.CO;2-D – reference: WagnerGCortical inefficiency in patients with unipolar depression: an event-related FMRI study with the Stroop taskBiol. Psychiatry20065995896510.1016/j.biopsych.2005.10.025 – reference: MillerJMElevated serotonin 1A binding in remitted major depressive disorder: evidence for a trait biological abnormalityNeuropsychopharmacology200934227522841:CAS:528:DC%2BD1MXpvFygtr4%3D10.1038/npp.2009.54 – reference: UchidaSEarly life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodentsJ. Neurosci.20103015007150181:CAS:528:DC%2BC3cXhsV2nurjO10.1523/JNEUROSCI.1436-10.2010 – reference: SobocińskaJLipopolysaccharide upregulates palmitoylated enzymes of the phosphatidylinositol cycle: an insight from proteomic studiesMol. Cell. Proteomics20181723325410.1074/mcp.RA117.000050 – reference: GlobaAKBamjiSXProtein palmitoylation in the development and plasticity of neuronal connectionsCurr. Opin. Neurobiol.2017452102201:CAS:528:DC%2BC2sXkvF2hsbY%3D10.1016/j.conb.2017.02.016 – reference: YokoiNIdentification of PSD-95 Depalmitoylating EnzymesJ. Neurosci.201636643164441:CAS:528:DC%2BC28XhsF2ku7nO10.1523/JNEUROSCI.0419-16.2016 – reference: KimAHMicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disordersSchizophr. Res.201012418319110.1016/j.schres.2010.07.002 – reference: ClineBHThe neuronal insulin sensitizer dicholine succinate reduces stress-induced depressive traits and memory deficit: possible role of insulin-like growth factor 2BMC Neurosci.2012131:CAS:528:DC%2BC3sXksFGmsL8%3D10.1186/1471-2202-13-110 – reference: PerkinsDOmicroRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorderGenome Biol.2007810.1186/gb-2007-8-2-r27 – reference: XuYA polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveformJ. Affect. Disord.20101273323361:CAS:528:DC%2BC3cXhtlyksbnO10.1016/j.jad.2010.05.019 – reference: PapouchevaEThe 5-hydroxytryptamine(1A) receptor is stably palmitoylated, and acylation is critical for communication of receptor with Gi proteinJ. Biol. Chem.20032793280329110.1074/jbc.M308177200 – reference: ChenSPalmitoylation-dependent activation of MC1R prevents melanomagenesisNature20175493994031:CAS:528:DC%2BC2sXhsVersrfI10.1038/nature238872017Natur.549..399C – reference: LinDTSConibearEEnzymatic protein depalmitoylation by acyl protein thioesterasesBiochem. Soc. Trans.2015431931981:CAS:528:DC%2BC2MXlvFSjtr4%3D10.1042/BST20140235 – reference: Del TrediciALPharmacology of polymorphic variants of the human 5-HT1A receptorBiochem. Pharmacol.20046747949010.1016/j.bcp.2003.09.030 – reference: KlemenhagenKCGordonJADavidDJHenRGrossCTIncreased fear response to contextual cues in mice lacking the 5-HT1A receptorNeuropsychopharmacology2006311011111:CAS:528:DC%2BD2MXhtlWjsrzK10.1038/sj.npp.1300774 – reference: LiYMartinBRCravattBFHofmannSLDHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cellsJ. Biol. Chem.20122875235301:CAS:528:DC%2BC38XotVeq10.1074/jbc.M111.306183 – reference: BuynitskyTMostofskyDIRestraint stress in biobehavioral research: Recent developmentsNeurosci. Biobehav. Rev.2009331089109810.1016/j.neubiorev.2009.05.004 – reference: BijataMSynaptic remodeling depends on signaling between serotonin receptors and the extracellular matrixCell Rep.201719176717821:CAS:528:DC%2BC2sXptVWlt7g%3D10.1016/j.celrep.2017.05.023 – reference: BartelDPMicroRNA target recognition and regulatory functionsCell20091362152331:CAS:528:DC%2BD1MXhs1Kiuro%3D10.1016/j.cell.2009.01.002 – reference: BrigidiGSPalmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticityNat. Neurosci.2014175225321:CAS:528:DC%2BC2cXivFahsr8%3D10.1038/nn.3657 – reference: SugimotoYAntidepressant-like effects of neferine in the forced swimming test involve the serotonin1A (5-HT1A) receptor in miceEur. J. Pharmacol.201063462671:CAS:528:DC%2BC3cXks1Wmt7Y%3D10.1016/j.ejphar.2010.02.016 – reference: CouchYMicroglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedoniaBrain. Behav. Immun.2013291361461:CAS:528:DC%2BC3sXhvFahs7g%3D10.1016/j.bbi.2012.12.017 – reference: DrevetsWCSerotonin type-1A receptor imaging in depressionNucl. Med. Biol.2000274995071:CAS:528:DC%2BD3cXmtVGjtLk%3D10.1016/S0969-8051(00)00119-0 – reference: MiyakeAKitamuraYMiyazakiIAsanumaMSendoTEffects of (+)-8-OH-DPAT on the duration of immobility during the forced swim test and hippocampal cell proliferation in ACTH-treated ratsPharmacol. Biochem. Behav.20141222402451:CAS:528:DC%2BC2cXpsl2lt7o%3D10.1016/j.pbb.2014.04.003 – reference: RoyBDunbarMSheltonRCDwivediYIdentification of microRNA-124-3p as a putative epigenetic signature of major depressive disorderNeuropsychopharmacology2017428648751:CAS:528:DC%2BC28Xhs1ajs7fO10.1038/npp.2016.175 – reference: PorsoltRDLe PichonMJalfreMDepression: a new animal model sensitive to antidepressant treatmentsNature19772667307321:CAS:528:DyaE2sXkvFGhur4%3D10.1038/266730a01977Natur.266..730P – reference: OttoSJA new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functionsJ. Neurosci.200727672967391:CAS:528:DC%2BD2sXnsVWqs7s%3D10.1523/JNEUROSCI.0091-07.2007 – reference: RongHMicroRNA-134 plasma levels before and after treatment for bipolar maniaJ. Psychiatr. Res.201145929510.1016/j.jpsychires.2010.04.028 – reference: WangJDHHC4 and DHHC5 facilitate fatty acid uptake by palmitoylating and targeting CD36 to the plasma membraneCell Rep.201926209221.e51:CAS:528:DC%2BC1MXjtVehug%3D%3D10.1016/j.celrep.2018.12.022 – reference: WirthAHolstKPonimaskinEHow serotonin receptors regulate morphogenic signalling in neuronsProg. Neurobiol.201715135561:CAS:528:DC%2BC28XltVKksr4%3D10.1016/j.pneurobio.2016.03.007 – reference: RennerUHeterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and traffickingJ. Cell Sci.2012125248624991:CAS:528:DC%2BC38XhtFehurvN10.1242/jcs.1013372012dfpb.book.....R – reference: Gerardy-SchahnREckhardtMHot spots of antigenicity in the neural cell adhesion molecule NCAMInt. J. Cancer Suppl.1994838421:CAS:528:DyaK28XmvVKqsA%3D%3D10.1002/ijc.2910570708 – reference: RinaldiAStress induces region specific alterations in microRNAs expression in miceBehav. Brain Res.20102082652691:CAS:528:DC%2BC3cXhs1altrY%3D10.1016/j.bbr.2009.11.012 – reference: MillPPalmitoylation regulates epidermal homeostasis and hair follicle differentiationPLoS Genet.20095e100074810.1371/journal.pgen.1000748 – reference: FonslowBRDigestion and depletion of abundant proteins improves proteomic coverageNat. Methods20131054561:CAS:528:DC%2BC38Xhs1ymt7bF10.1038/nmeth.2250 – reference: BiverFFrontal and parietal metabolic disturbances in unipolar depressionBiol. Psychiatry1994363813881:STN:280:DyaK2M7gtFynsw%3D%3D10.1016/0006-3223(94)91213-0 – reference: ErdmannJSystematic screening for mutations in the promoter and the coding region of the 5-HT1A geneAm. J. Med. Genet.1995603933991:STN:280:DyaK287hvFChtg%3D%3D10.1002/ajmg.1320600509 – reference: SargentPABrain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatmentArch. Gen. Psychiatry2000571741801:CAS:528:DC%2BD3cXhtFyqsrs%3D10.1001/archpsyc.57.2.174 – reference: LopezJPmiR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatmentNat. Med.2014207647681:CAS:528:DC%2BC2cXpsVamtr0%3D10.1038/nm.3582 – reference: StockmeierCAIncrease in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activityJ. Neurosci.199818739474011:CAS:528:DyaK1cXmt1Sjtbs%3D10.1523/JNEUROSCI.18-18-07394.1998 – reference: BarrosMAnxiolytic-like effects of the selective 5-HT1A receptor antagonist WAY 100635 in non-human primatesEur. J. Pharmacol.20034821972031:CAS:528:DC%2BD3sXps1Oku74%3D10.1016/j.ejphar.2003.09.064 – reference: GHO | World Health Statistics data visualizations dashboard | Suicide. WHO. Available at http://apps.who.int/gho/data/node.sdg.3-4-viz-2?lang=en. Accessed 15 May 2018 – reference: KulikovAVTikhonovaMAKulikovVAAutomated measurement of spatial preference in the open field test with transmitted lightingJ. Neurosci. Methods200817034535110.1016/j.jneumeth.2008.01.024 – reference: ParseyRVHigher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic studyNeuropsychopharmacology200631174517491:CAS:528:DC%2BD28XmvFCntbc%3D10.1038/sj.npp.1300992 – reference: LeinESGenome-wide atlas of gene expression in the adult mouse brainNature20074451681761:CAS:528:DC%2BD2sXjtFKjtw%3D%3D10.1038/nature054532007Natur.445..168L – reference: MayorgaAJLuckiILimitations on the use of the C57BL/6 mouse in the tail suspension testPsychopharmacology (Berl.)20011551101121:CAS:528:DC%2BD3MXjslCrtLc%3D10.1007/s002130100687 – reference: Prasad, S., Zeug, A. & Ponimaskin, E. Analysis of receptor–receptor interaction by combined application of FRET and microscopy. Methods Cell Biol.117, 243–265 (2013). – reference: SalonikidisPSAn ion-insensitive cAMP biosensor for long term quantitative ratiometric fluorescence resonance energy transfer (FRET) measurements under variable physiological conditionsJ. Biol. Chem.201128623419234311:CAS:528:DC%2BC3MXnvFersbs%3D10.1074/jbc.M111.236869 – reference: RennerULocalization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signalingMol. Pharmacol.2007725025131:CAS:528:DC%2BD2sXhtVSgurbP10.1124/mol.107.037085 – reference: ChaiSCambronneXAEichhornSWGoodmanRHMicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9Proc. Natl Acad. Sci. USA201311017898179031:CAS:528:DC%2BC3sXhvVWmur%2FM10.1073/pnas.13175281102013PNAS..11017898C – reference: StrekalovaTSpanagelRDolgovOBartschDStress-induced hyperlocomotion as a confounding factor in anxiety and depression models in miceBehav. Pharmacol.2005161711801:STN:280:DC%2BD2M3islKitQ%3D%3D10.1097/00008877-200505000-00006 – reference: ClineBHLasting downregulation of the lipid peroxidation enzymes in the prefrontal cortex of mice susceptible to stress-induced anhedoniaBehav. Brain Res.20152761181291:CAS:528:DC%2BC2cXotFOrtr0%3D10.1016/j.bbr.2014.04.037 – reference: HirvonenJDecreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635Int. J. Neuropsychopharmacol.2008114654761:CAS:528:DC%2BD1cXmt1Kqt74%3D10.1017/S1461145707008140 – reference: DellingMThe neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid raftsJ. Neurosci.200222715471641:CAS:528:DC%2BD38XmsF2gsb8%3D10.1523/JNEUROSCI.22-16-07154.2002 – reference: MalinowskaADiffprot - software for non-parametric statistical analysis of differential proteomics dataJ. Proteomics201275406240731:CAS:528:DC%2BC38XosVarsbY%3D10.1016/j.jprot.2012.05.030 – reference: GrossCSerotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adultNature20024163964001:CAS:528:DC%2BD38XislantLo%3D10.1038/416396a2002Natur.416..396G – reference: WuLBelascoJGLet me count the ways: mechanisms of gene regulation by miRNAs and siRNAsMol. Cell2008291710.1016/j.molcel.2007.12.010 – reference: StrekalovaTSpanagelRBartschDHennFAGassPStress-induced anhedonia in mice is associated with deficits in forced swimming and explorationNeuropsychopharmacology2004292007201710.1038/sj.npp.1300532 – reference: OhnoYKiharaASanoTIgarashiYIntracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteinsBiochim. Biophys. Acta200617614744831:CAS:528:DC%2BD28XltFGjt7w%3D10.1016/j.bbalip.2006.03.010 – reference: ArikeLPeilLSpectral counting label-free proteomicsMethods Mol. Biol.201411562132221:CAS:528:DC%2BC2MXnvFGkurs%3D10.1007/978-1-4939-0685-7_14 – reference: ParksCLRobinsonPSSibilleEShenkTTothMIncreased anxiety of mice lacking the serotonin1A receptorProc. Natl Acad. Sci. USA19989510734107391:CAS:528:DyaK1cXlvFWgsbY%3D10.1073/pnas.95.18.107341998PNAS...9510734P – reference: ParseyRVAltered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography studyBiol. Psychiatry2006591061131:CAS:528:DC%2BD28XotVGksg%3D%3D10.1016/j.biopsych.2005.06.016 – reference: Slotnick, B. M. & Leonard, C. M. A Stereotaxic Atlas of the Albino Mouse Forebrain (U.S. Dept. of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, 1975). – reference: First, M. B., Williams, J. B. W., Spitzer, R. L. & Gibbon, M. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) (American Psychiatric Publications, 1997). – reference: MeersonAChanges in brain MicroRNAs contribute to cholinergic stress reactionsJ. Mol. Neurosci.20104047551:CAS:528:DC%2BC3cXmvFSrtA%3D%3D10.1007/s12031-009-9252-1 – reference: SunNPreliminary comparison of plasma notch-associated microRNA-34b and -34c levels in drug naive, first episode depressed patients and healthy controlsJ. Affect. Disord.20161941091141:CAS:528:DC%2BC28XpsVajtg%3D%3D10.1016/j.jad.2016.01.017 – reference: ConacoCOttoSHanJ-JMandelGReciprocal actions of REST and a microRNA promote neuronal identityProc. Natl Acad. Sci. USA2006103242224271:CAS:528:DC%2BD28XhslGjtLo%3D10.1073/pnas.05110411032006PNAS..103.2422C – reference: SchepelerTAttenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genesOncogene201231275027601:CAS:528:DC%2BC3MXht1GqsL3I10.1038/onc.2011.453 – reference: KitrakiEKremmydaOYoulatosDAlexisMNKittasCGender-dependent alterations in corticosteroid receptor status and spatial performance following 21 days of restraint stressNeuroscience200412547551:CAS:528:DC%2BD2cXisFylsrc%3D10.1016/j.neuroscience.2003.12.024 – reference: GaleaLASex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stressNeuroscience1997816896971:CAS:528:DyaK2sXmtleltrs%3D10.1016/S0306-4522(97)00233-9 – reference: WuSComingsDEA common C-1018G polymorphism in the human 5-HT1A receptor genePsychiatr. Genet.199991051:STN:280:DyaK1MzktVKrug%3D%3D10.1097/00041444-199906000-00010 – volume: 151 start-page: 35 year: 2017 ident: 11876_CR9 publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2016.03.007 – volume: 59 start-page: 958 year: 2006 ident: 11876_CR23 publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2005.10.025 – volume: 279 start-page: 3280 year: 2003 ident: 11876_CR12 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M308177200 – volume: 29 start-page: 136 year: 2013 ident: 11876_CR71 publication-title: Brain. Behav. Immun. doi: 10.1016/j.bbi.2012.12.017 – volume: 29 start-page: 1 year: 2008 ident: 11876_CR35 publication-title: Mol. Cell doi: 10.1016/j.molcel.2007.12.010 – volume: 45 start-page: 92 year: 2011 ident: 11876_CR54 publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2010.04.028 – volume: 55 start-page: 225 year: 2004 ident: 11876_CR38 publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2003.09.017 – volume: 16 start-page: 171 year: 2005 ident: 11876_CR72 publication-title: Behav. Pharmacol. doi: 10.1097/00008877-200505000-00006 – volume: 125 start-page: 2486 year: 2012 ident: 11876_CR11 publication-title: J. Cell Sci. doi: 10.1242/jcs.101337 – volume: 43 start-page: 193 year: 2015 ident: 11876_CR24 publication-title: Biochem. Soc. Trans. doi: 10.1042/BST20140235 – volume: 110 start-page: 17898 year: 2013 ident: 11876_CR36 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1317528110 – volume: 416 start-page: 396 year: 2002 ident: 11876_CR6 publication-title: Nature doi: 10.1038/416396a – volume: 155 start-page: 110 year: 2001 ident: 11876_CR30 publication-title: Psychopharmacology (Berl.) doi: 10.1007/s002130100687 – volume: 208 start-page: 265 year: 2010 ident: 11876_CR63 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2009.11.012 – volume: 482 start-page: 197 year: 2003 ident: 11876_CR7 publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2003.09.064 – volume: 445 start-page: 168 year: 2007 ident: 11876_CR27 publication-title: Nature doi: 10.1038/nature05453 – volume: 31 start-page: 2750 year: 2012 ident: 11876_CR61 publication-title: Oncogene doi: 10.1038/onc.2011.453 – volume: 1761 start-page: 474 year: 2006 ident: 11876_CR15 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbalip.2006.03.010 – volume: 136 start-page: 215 year: 2009 ident: 11876_CR53 publication-title: Cell doi: 10.1016/j.cell.2009.01.002 – volume: 8 start-page: 38 year: 1994 ident: 11876_CR75 publication-title: Int. J. Cancer Suppl. doi: 10.1002/ijc.2910570708 – volume: 122 start-page: 240 year: 2014 ident: 11876_CR34 publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/j.pbb.2014.04.003 – volume: 29 start-page: 2007 year: 2004 ident: 11876_CR19 publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300532 – volume: 44 start-page: 987 year: 2004 ident: 11876_CR76 publication-title: Neuron doi: 10.1016/j.neuron.2004.12.005 – volume: 8 year: 2007 ident: 11876_CR60 publication-title: Genome Biol. doi: 10.1186/gb-2007-8-2-r27 – volume: 5 start-page: e1000748 year: 2009 ident: 11876_CR16 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000748 – volume: 36 start-page: 2208 year: 2016 ident: 11876_CR17 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00144-16 – volume: 287 start-page: 523 year: 2012 ident: 11876_CR49 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.306183 – volume: 19 start-page: 1767 year: 2017 ident: 11876_CR74 publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.05.023 – volume: 17 start-page: 522 year: 2014 ident: 11876_CR48 publication-title: Nat. Neurosci. doi: 10.1038/nn.3657 – volume: 73 start-page: 482 year: 2012 ident: 11876_CR47 publication-title: Neuron doi: 10.1016/j.neuron.2011.11.021 – volume: 75 start-page: 4062 year: 2012 ident: 11876_CR79 publication-title: J. Proteomics doi: 10.1016/j.jprot.2012.05.030 – ident: 11876_CR1 – ident: 11876_CR67 – ident: 11876_CR77 – volume: 60 start-page: 393 year: 1995 ident: 11876_CR43 publication-title: Am. J. Med. Genet. doi: 10.1002/ajmg.1320600509 – volume: 27 start-page: 499 year: 2000 ident: 11876_CR2 publication-title: Nucl. Med. Biol. doi: 10.1016/S0969-8051(00)00119-0 – volume: 33 start-page: 1089 year: 2009 ident: 11876_CR69 publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2009.05.004 – volume: 42 start-page: 864 year: 2017 ident: 11876_CR57 publication-title: Neuropsychopharmacology doi: 10.1038/npp.2016.175 – volume: 456 start-page: 311 year: 2013 ident: 11876_CR14 publication-title: Biochem. J. doi: 10.1042/BJ20130788 – volume: 17 start-page: 233 year: 2018 ident: 11876_CR31 publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.RA117.000050 – volume: 20 start-page: 764 year: 2014 ident: 11876_CR56 publication-title: Nat. Med. doi: 10.1038/nm.3582 – volume: 22 start-page: 7154 year: 2002 ident: 11876_CR10 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-16-07154.2002 – volume: 45 start-page: 210 year: 2017 ident: 11876_CR28 publication-title: Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2017.02.016 – volume: 27 start-page: 6729 year: 2007 ident: 11876_CR66 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0091-07.2007 – volume: 10 start-page: 54 year: 2013 ident: 11876_CR32 publication-title: Nat. Methods doi: 10.1038/nmeth.2250 – volume: 266 start-page: 730 year: 1977 ident: 11876_CR70 publication-title: Nature doi: 10.1038/266730a0 – volume: 59 start-page: 106 year: 2006 ident: 11876_CR41 publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2005.06.016 – volume: 81 start-page: 689 year: 1997 ident: 11876_CR68 publication-title: Neuroscience doi: 10.1016/S0306-4522(97)00233-9 – volume: 40 start-page: 47 year: 2010 ident: 11876_CR62 publication-title: J. Mol. Neurosci. doi: 10.1007/s12031-009-9252-1 – volume: 170 start-page: 345 year: 2008 ident: 11876_CR73 publication-title: J. Neurosci. Methods doi: 10.1016/j.jneumeth.2008.01.024 – volume: 634 start-page: 62 year: 2010 ident: 11876_CR33 publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2010.02.016 – volume: 36 start-page: 6431 year: 2016 ident: 11876_CR26 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0419-16.2016 – volume: 125 start-page: 47 year: 2004 ident: 11876_CR29 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2003.12.024 – volume: 18 start-page: 7394 year: 1998 ident: 11876_CR39 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.18-18-07394.1998 – volume: 34 start-page: 2275 year: 2009 ident: 11876_CR42 publication-title: Neuropsychopharmacology doi: 10.1038/npp.2009.54 – volume: 11 start-page: 161 year: 2010 ident: 11876_CR46 publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2788 – volume: 127 start-page: 332 year: 2010 ident: 11876_CR59 publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2010.05.019 – volume: 26 start-page: 209 year: 2019 ident: 11876_CR52 publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.12.022 – volume: 13 year: 2012 ident: 11876_CR20 publication-title: BMC Neurosci. doi: 10.1186/1471-2202-13-110 – volume: 31 start-page: 101 year: 2006 ident: 11876_CR5 publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300774 – volume: 30 start-page: 15007 year: 2010 ident: 11876_CR64 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1436-10.2010 – volume: 103 start-page: 2422 year: 2006 ident: 11876_CR65 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0511041103 – volume: 9 start-page: 105 year: 1999 ident: 11876_CR4 publication-title: Psychiatr. Genet. doi: 10.1097/00041444-199906000-00010 – ident: 11876_CR78 doi: 10.1016/B978-0-12-408143-7.00014-1 – volume: 95 start-page: 10734 year: 1998 ident: 11876_CR8 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.95.18.10734 – volume: 36 start-page: 381 year: 1994 ident: 11876_CR22 publication-title: Biol. Psychiatry doi: 10.1016/0006-3223(94)91213-0 – volume: 549 start-page: 399 year: 2017 ident: 11876_CR51 publication-title: Nature doi: 10.1038/nature23887 – volume: 4 start-page: e11306 year: 2015 ident: 11876_CR25 publication-title: eLife doi: 10.7554/eLife.11306 – volume: 72 start-page: 502 year: 2007 ident: 11876_CR13 publication-title: Mol. Pharmacol. doi: 10.1124/mol.107.037085 – volume: 57 start-page: 174 year: 2000 ident: 11876_CR37 publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.57.2.174 – volume: 31 start-page: 1745 year: 2006 ident: 11876_CR40 publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300992 – volume: 11 start-page: 465 year: 2008 ident: 11876_CR3 publication-title: Int. J. Neuropsychopharmacol. doi: 10.1017/S1461145707008140 – volume: 111 start-page: 17534 year: 2014 ident: 11876_CR50 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1413627111 – volume: 286 start-page: 23419 year: 2011 ident: 11876_CR18 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.236869 – volume: 81 start-page: 434 year: 1998 ident: 11876_CR44 publication-title: Am. J. Med. Genet. doi: 10.1002/(SICI)1096-8628(19980907)81:5<434::AID-AJMG13>3.0.CO;2-D – volume: 124 start-page: 183 year: 2010 ident: 11876_CR55 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2010.07.002 – volume: 194 start-page: 109 year: 2016 ident: 11876_CR58 publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2016.01.017 – volume: 1156 start-page: 213 year: 2014 ident: 11876_CR80 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-4939-0685-7_14 – volume: 276 start-page: 118 year: 2015 ident: 11876_CR21 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2014.04.037 – volume: 67 start-page: 479 year: 2004 ident: 11876_CR45 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2003.09.030 |
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| Snippet | The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR... Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the... |
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| Title | Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
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