EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKA activation and SNAP23-containing complexes

Background Ectodysplasin-A (EDA), a skin-specific TNF ligand, interacts with its membrane receptor EDAR to trigger EDA signaling in skin appendage formation. Gene mutations in EDA signaling cause Anhidrotic/Hypohidrotic Ectodermal Dysplasia (A/HED), which affects the formation of skin appendages inc...

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Bibliographic Details
Published in:	Cell & bioscience Vol. 13; no. 1; pp. 128 - 15
Main Authors:	Yao, Yuyuan, Yang, Ruihan, Zhu, Jian, Schlessinger, David, Sima, Jian
Format:	Journal Article
Language:	English
Published:	London BioMed Central 10.07.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Antibodies Appendages Biomedical and Life Sciences Cell Biology Cell membranes Cells Cloning Dysplasia Ectodysplasin EDA EDAR Exocrine glands Gene expression Gene mutations Genetic aspects Glycerol HED Laboratory animals Life Sciences Ligands Membrane proteins Membrane trafficking Microbiology Mutagenesis Mutation Neurobiology Plasma Plasmids Protein purification Proteins Proteomics Signal transduction Skin Stem Cells TNFR Tumor necrosis factor China EDAR TNFR Membrane trafficking EDA HED
ISSN:	2045-3701, 2045-3701
Online Access:	Get full text
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