Early economic evaluation of chelation therapy in kidney transplant recipients with high-normal lead

Kidney transplant recipients (KTR) with high-normal lead have a higher risk of graft failure (GF). Clinically, chelation therapy using meso-2,3-dimercaptosuccinic acid (DMSA) removes lead. Despite the proposal that chelation therapy can prevent GF through lead removal, evidence is lacking. To guide...

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Bibliographic Details
Published in:	PloS one Vol. 20; no. 2; p. e0319022
Main Authors:	Hao, Jiasi, Alizadeh, Behrooz Z., Postma, Maarten J., Touw, Daan J., Bakker, Stephan J. L., de Jong, Lisa A.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 27.02.2025 Public Library of Science (PLoS)
Subjects:	Biology and Life Sciences Care and treatment Chelating Agents - economics Chelating Agents - therapeutic use Chelation Chelation therapy Chelation Therapy - economics Chelation Therapy - methods Comparative analysis Cost analysis Cost effectiveness Cost-Benefit Analysis Dimercaptosuccinic acid Economic aspects Economics Ethylenediaminetetraacetic acid Evaluation Female Graft rejection Grafting Heavy metals Hemodialysis Humans Intervention Kidney diseases Kidney transplantation Kidney Transplantation - adverse effects Kidney Transplantation - economics Kidney transplants Kidneys Lead - blood Lead content Lead poisoning Male Markov Chains Markov processes Medical care, Cost of Medicine and Health Sciences Netherlands Organ transplant recipients Patient outcomes Patients Peritoneal dialysis Physical Sciences Plasma Renal replacement therapy Sensitivity analysis Social Sciences Standard of care Statistical analysis Succimer - economics Succimer - therapeutic use Survival Therapy Transition probabilities Transplant Recipients Transplantation Uncertainty Netherlands
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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