Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T cells at such tumor sites . However, these efforts only have value if the intratumoral T cell receptor (TCR) repertoire of such cells is intr...

Full description

Saved in:

Bibliographic Details
Published in:	Nature medicine Vol. 25; no. 1; pp. 89 - 94
Main Authors:	Scheper, Wouter, Kelderman, Sander, Fanchi, Lorenzo F, Linnemann, Carsten, Bendle, Gavin, de Rooij, Marije A J, Hirt, Christian, Mezzadra, Riccardo, Slagter, Maarten, Dijkstra, Krijn, Kluin, Roelof J C, Snaebjornsson, Petur, Milne, Katy, Nelson, Brad H, Zijlmans, Henry, Kenter, Gemma, Voest, Emile E, Haanen, John B A G, Schumacher, Ton N
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.01.2019
Subjects:	CD8 antigen CD8-Positive T-Lymphocytes - immunology Colorectal cancer Colorectal carcinoma Humans Infiltration Jurkat Cells Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Metastases Neoplasms - immunology Neoplasms - pathology Ovarian cancer Phenotype Receptors, Antigen, T-Cell - metabolism Reproducibility of Results T cell receptors Tumors
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!