Environmental exposures in early-life and general health in childhood

Background Early-life environmental exposures are suspected to be involved in the development of chronic diseases later in life. Most studies conducted so far considered single or few exposures and single-health parameter. Our study aimed to identify a childhood general health score and assess its a...

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Vydané v:	Environmental health Ročník 22; číslo 1; s. 53 - 14
Hlavní autori:	Amine, Ines, Guillien, Alicia, Philippat, Claire, Anguita-Ruiz, Augusto, Casas, Maribel, de Castro, Montserrat, Dedele, Audrius, Garcia-Aymerich, Judith, Granum, Berit, Grazuleviciene, Regina, Heude, Barbara, Haug, Line Småstuen, Julvez, Jordi, López-Vicente, Mónica, Maitre, Léa, McEachan, Rosemary, Nieuwenhuijsen, Mark, Stratakis, Nikos, Vafeiadi, Marina, Wright, John, Yang, Tiffany, Yuan, Wen Lun, Basagaña, Xavier, Slama, Rémy, Vrijheid, Martine, Siroux, Valérie
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 21.07.2023 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Air pollution Allergies Asthma Cardiometabolic risk factors Childhood Children Children & youth Chronic illnesses Cobalt Cohort analysis Cohort studies Earth and Environmental Science Environment Environmental factors Environmental Health Exposome Exposure Fetus Growth Health aspects Hypotheses Hypothesis testing Indoor air pollution Indoor environments Influence Life Sciences Mental health Neurodevelopment Occupational Medicine/Industrial Medicine Organic compounds Organochlorine compounds Outdoor air quality Parameter identification Pets Physical activity Pollutants Pollution Pregnancy Pregnant women Prenatal experience Prenatal exposure Public Health Questionnaires Respiratory diseases Santé publique et épidémiologie Tobacco Triglycerides France Pregnancy Cardiometabolic risk factors Respiratory diseases Cohort studies Neurodevelopment Environment Exposome Child General health status Multimorbidity
ISSN:	1476-069X, 1476-069X
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Shrnutí:	Background Early-life environmental exposures are suspected to be involved in the development of chronic diseases later in life. Most studies conducted so far considered single or few exposures and single-health parameter. Our study aimed to identify a childhood general health score and assess its association with a wide range of pre- and post-natal environmental exposures. Methods The analysis is based on 870 children (6–12 years) from six European birth cohorts participating in the Human Early-Life Exposome project. A total of 53 prenatal and 105 childhood environmental factors were considered, including lifestyle, social, urban and chemical exposures. We built a general health score by averaging three sub-scores (cardiometabolic, respiratory/allergy and mental) built from 15 health parameters. By construct, a child with a low score has a low general health status. Penalized multivariable regression through Least Absolute Shrinkage and Selection Operator (LASSO) was fitted in order to identify exposures associated with the general health score. Findings The results of LASSO show that a lower general health score was associated with maternal passive and active smoking during pregnancy and postnatal exposure to methylparaben, copper, indoor air pollutants, high intake of caffeinated drinks and few contacts with friends and family. Higher child’s general health score was associated with prenatal exposure to a bluespace near residency and postnatal exposures to pets, cobalt, high intakes of vegetables and more physical activity. Against our hypotheses, postnatal exposure to organochlorine compounds and perfluorooctanoate were associated with a higher child’s general health score. Conclusion By using a general health score summarizing the child cardiometabolic, respiratory/allergy and mental health, this study reinforced previously suspected environmental factors associated with various child health parameters (e.g. tobacco, air pollutants) and identified new factors (e.g. pets, bluespace) warranting further investigations.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1476-069X 1476-069X
DOI:	10.1186/s12940-023-01001-x