Environmental risk factors and changing spatial patterns of human seropositivity for Echinococcus spp. in Xiji County, Ningxia Hui Autonomous Region, China

Background Human echinococcoses are parasitic helminth infections that constitute a serious public health concern in several regions across the world. Cystic (CE) and alveolar echinococcosis (AE) in China represent a high proportion of the total global burden of these infections. This study was cond...

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Veröffentlicht in:Parasites & vectors Jg. 11; H. 1; S. 159
Hauptverfasser: Cadavid Restrepo, Angela M., Yang, Yu Rong, McManus, Donald P., Gray, Darren J., Barnes, Tamsin S., Williams, Gail M., Soares Magalhães, Ricardo J., Clements, Archie C. A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 09.03.2018
BioMed Central Ltd
BMC
Schlagworte:
Adolescent
Animals
Antibodies, Helminth - blood
Bayesian theory
Biomedical and Life Sciences
Biomedicine
Child
China
China - epidemiology
Cross-Sectional Studies
Echinococcosis
Echinococcosis - epidemiology
Echinococcosis - parasitology
Echinococcus granulosus
Echinococcus granulosus - immunology
Echinococcus multilocularis
Echinococcus multilocularis - immunology
Entomology
Environment
Environmental Exposure
Environmental health
Female
forests
Geographical information systems
geostatistics
habitat fragmentation
helminths
Human echinococcoses
Humans
Infectious Diseases
Male
Medical research
Medicine, Experimental
meteorological data
Methods
Models, Statistical
Parasitology
public health
Public health administration
Remote sensing
risk
Risk Factors
satellites
Seroepidemiologic Studies
seroprevalence
shrublands
Spatial Analysis
species
summer
Topography, Medical
Tropical Medicine
Veterinary Medicine/Veterinary Science
Virology
China
Environment
Ningxia Hui Autonomous Region
Geographical information systems
Remote sensing
Human echinococcoses
Xiji County
Echinococcus multilocularis
Echinococcus granulosus
ISSN:1756-3305, 1756-3305
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Zusammenfassung:Background Human echinococcoses are parasitic helminth infections that constitute a serious public health concern in several regions across the world. Cystic (CE) and alveolar echinococcosis (AE) in China represent a high proportion of the total global burden of these infections. This study was conducted to predict the spatial distribution of human seropositivity for Echinococcus species in Xiji County, Ningxia Hui Autonomous Region (NHAR), with the aim of identifying communities where targeted prevention and control efforts are required. Methods Bayesian geostatistical models with environmental and demographic covariates were developed to predict spatial variation in the risk of human seropositivity for Echinococcus granulosus (the cause of CE) and E. multilocularis (the cause of AE). Data were collected from three cross-sectional surveys of school children conducted in Xiji County in 2002–2003, 2006–2007 and 2012–2013. Environmental data were derived from high-resolution satellite images and meteorological data. Results The overall seroprevalence of E. granulosus and E. multilocularis was 33.4 and 12.2%, respectively, across the three surveys. Seropositivity for E. granulosus was significantly associated with summer and winter precipitation, landscape fragmentation variables and the extent of areas covered by forest, shrubland, water and bareland/artificial surfaces. Seropositivity for E. multilocularis was significantly associated with summer and winter precipitations, landscape fragmentation variables and the extent of shrubland and water bodies. Spatial correlation occurred over greater distances for E. granulosus than for E. multilocularis. The predictive maps showed that the risk of seropositivity for E. granulosus expanded across Xiji during the three surveys, while the risk of seropositivity for E. multilocularis became more confined in communities located in the south. Conclusions The identification of high-risk areas for seropositivity for these parasites, and a better understanding of the role of the environment in determining the transmission dynamics of Echinococcus spp. may help to guide and monitor improvements in human echinococcosis control strategies by allowing targeted allocation of resources.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1756-3305
1756-3305
DOI:10.1186/s13071-018-2764-1