Effect of antibody-mediated connective tissue growth factor neutralization on lung edema in ventilator-induced lung injury in rats

Background Acute respiratory distress syndrome (ARDS) is characterized by alveolar edema that can progress to septal fibrosis. Mechanical ventilation can augment lung injury, termed ventilator-induced lung injury (VILI). Connective tissue growth factor (CTGF), a mediator of fibrosis, is increased in...

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Bibliographic Details
Published in:	Molecular medicine (Cambridge, Mass.) Vol. 30; no. 1; pp. 68 - 11
Main Authors:	van den Brom, Charissa E., Bozic, Caitlin, Polet, Chantal A., Bongers, Annabel, Tuip-de Boer, Anita M., Ibelings, Roselique, Roelofs, Joris J. T. H., Juffermans, Nicole P.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 22.05.2024 Springer Nature B.V BMC
Subjects:	Animals Antibodies Antibodies, Neutralizing - pharmacology ARDS Biomedical and Life Sciences Biomedicine Blood gas analysis Blood pressure Carotid arteries Catheters Connective tissue Connective Tissue Growth Factor - antagonists & inhibitors Connective Tissue Growth Factor - metabolism CTGF Disease Models, Animal Edema Growth factors Ketamine Lung Lung - metabolism Lung - pathology Lungs Male Molecular Medicine Permeability Pulmonary Edema - etiology Pulmonary Edema - metabolism Pulmonary fibrosis Rats Rats, Sprague-Dawley Receptor for Advanced Glycation End Products - antagonists & inhibitors Receptor for Advanced Glycation End Products - metabolism Research Article Ventilator-induced lung injury Ventilator-Induced Lung Injury - drug therapy Ventilator-Induced Lung Injury - metabolism Ventilator-Induced Lung Injury - pathology Ventilators Sweden Netherlands San Francisco California United States > US Germany Missouri Edema Ventilator-induced lung injury Lung ARDS CTGF
ISSN:	1528-3658, 1076-1551, 1528-3658
Online Access:	Get full text
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