The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study

Background Genome-wide association studies have reported a genetic overlap between borderline personality disorder (BPD) and schizophrenia (SCZ). Epidemiologically, the direction and causality of the association between thyroid function and risk of BPD and SCZ are unclear. We aim to test whether gen...

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Vydané v:Borderline personality disorder and emotion dysregulation Ročník 11; číslo 1; s. 2 - 7
Hlavní autori: Babajide, Oladapo, Kjaergaard, Alisa D., Deng, Weichen, Kuś, Aleksander, Sterenborg, Rosalie B. T. M., Åsvold, Bjørn Olav, Burgess, Stephen, Teumer, Alexander, Medici, Marco, Ellervik, Christina, Nick, Bass, Deloukas, Panos, Marouli, Eirini
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 15.02.2024
BioMed Central Ltd
Springer Nature B.V
BMC
Predmet:
Alzheimer's disease
Autism
Bipolar disorder
Borderline Personality Disorder
Child and Adolescent Psychiatry
Consortia
Forensic Psychiatry
FT4
Genetic aspects
Genetics
Genomics
Hormone replacement therapy
Hypothyroidism
Medicine
Medicine & Public Health
Mendelian Randomisation
Mental depression
Mental disorders
Post traumatic stress disorder
Psychiatry
Psychotherapy
Schizophrenia
Thyroid function
Thyroid gland
Thyroid hormones
TSH
Twin studies
Twins
Schizophrenia
TSH
Borderline Personality Disorder
Thyroid function
FT4
Mendelian Randomisation
ISSN:2051-6673, 2051-6673
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Shrnutí:Background Genome-wide association studies have reported a genetic overlap between borderline personality disorder (BPD) and schizophrenia (SCZ). Epidemiologically, the direction and causality of the association between thyroid function and risk of BPD and SCZ are unclear. We aim to test whether genetically predicted variations in TSH and FT4 levels or hypothyroidism are associated with the risk of BPD and SCZ. Methods We employed Mendelian Randomisation (MR) analyses using genetic instruments associated with TSH and FT4 levels as well as hypothyroidism to examine the effects of genetically predicted thyroid function on BPD and SCZ risk. Bidirectional MR analyses were employed to investigate a potential reverse causal association. Results Genetically predicted higher FT4 was not associated with the risk of BPD (OR: 1.18; P  = 0.60, IVW) or the risk of SCZ (OR: 0.93; P  = 0.19, IVW). Genetically predicted higher TSH was not associated with the risk of BPD (OR: 1.11; P  = 0.51, IVW) or SCZ (OR: 0.98, P  = 0.55, IVW). Genetically predicted hypothyroidism was not associated with BPD or SCZ. We found no evidence for a reverse causal effect between BPD or SCZ on thyroid function. Conclusions We report evidence for a null association between genetically predicted FT4, TSH or hypothyroidism with BPD or SCZ risk. There was no evidence for reverse causality.
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ISSN:2051-6673
2051-6673
DOI:10.1186/s40479-024-00246-3