Direct cell reprogramming: approaches, mechanisms and progress

The reprogramming of somatic cells with defined factors, which converts cells from one lineage into cells of another, has greatly reshaped our traditional views on cell identity and cell fate determination. Direct reprogramming (also known as transdifferentiation) refers to cell fate conversion with...

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Bibliographic Details
Published in:	Nature reviews. Molecular cell biology Vol. 22; no. 6; pp. 410 - 424
Main Authors:	Wang, Haofei, Yang, Yuchen, Liu, Jiandong, Qian, Li
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.06.2021 Nature Publishing Group
Subjects:	631/532 631/532/2435 Animals Biochemistry Bioengineering Biomedical and Life Sciences Cancer Research Cardiomyocytes Cell Biology Cell Differentiation - genetics Cell Differentiation - physiology Cell fate Cell metabolism Cell research Cell Transdifferentiation - genetics Cell Transdifferentiation - physiology Cellular Reprogramming - genetics Cellular Reprogramming - physiology Developmental Biology Epigenesis, Genetic - genetics Epigenetics Fibroblasts Genetic aspects Humans Life Sciences Maturation Medicine Metabolism Methods Molecular modelling Non-coding RNA Pluripotency Review Article Somatic cells Stem Cells Therapeutic applications Transcription factors Transdifferentiation Translation United States
ISSN:	1471-0072, 1471-0080, 1471-0080
Online Access:	Get full text
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