Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: an updated meta-analysis

Background We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer’s disease(AD). Methods We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles publis...

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Published in:BMC neurology Vol. 19; no. 1; pp. 284 - 11
Main Authors: Chai, Bingyan, Gao, Fulin, Wu, Ruipeng, Dong, Tong, Gu, Cheng, Lin, Qiaoran, Zhang, Yi
Format: Journal Article
Language:English
Published: London BioMed Central 13.11.2019
BioMed Central Ltd
BMC
Subjects:
Advertising executives
Algorithms
Alzheimer Disease - blood
Alzheimer's disease
Anopheles
Cross-Sectional Studies
Database industry
Databases, Factual
Dementia
Dementia - blood
Dementias
Humans
International economic relations
Medicine
Medicine & Public Health
Meta-analysis
Neurochemistry
Neurology
Neurosurgery
Proportional Hazards Models
Prospective Studies
Research Article
Risk Factors
Vitamin D
Vitamin D - blood
Vitamin D deficiency
Vitamin D Deficiency - complications
Vitamins
Vitamin D deficiency
Alzheimer’s disease
Dementia
Meta-analysis
ISSN:1471-2377, 1471-2377
Online Access:Get full text
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Summary:Background We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer’s disease(AD). Methods We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package. Results Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml). In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10–20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml). Conclusion There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10–20 ng/ml).
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ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-019-1500-6