Rhamnolipid the Glycolipid Biosurfactant: Emerging trends and promising strategies in the field of biotechnology and biomedicine

Rhamnolipids (RLs) are surface-active compounds and belong to the class of glycolipid biosurfactants, mainly produced from Pseudomonas aeruginosa . Due to their non-toxicity, high biodegradability, low surface tension and minimum inhibitory concentration values, they have gained attention in various...

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Vydáno v:Microbial cell factories Ročník 20; číslo 1; s. 1 - 15
Hlavní autoři: Thakur, Priyanka, Saini, Neeraj K., Thakur, Vijay Kumar, Gupta, Vijai Kumar, Saini, Reena V., Saini, Adesh K.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 04.01.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Antiinfectives and antibacterials
Antimicrobial agents
Antitumor agents
Apoptosis
Applied Microbiology
Bacteria
Biocompatibility
Biodegradability
Biodegradation
Biofilms
Biological properties
Biomedical materials
Biosurfactants
Biosynthesis
Biotechnology
Breast cancer
Cell cycle
Cell proliferation
Chemical compounds
Chemistry
Chemistry and Materials Science
Cosmetics
Cytotoxicity
Drug delivery
Enzymes
Enzymology
Fatty acids
Food
Food cans
Food industry
Fungi
Genes
Genetic Engineering
Germination
Glycolipids
Health aspects
Health care
Hydrocarbons
Hydrophobicity
Immune system
Immunomodulation
Immunomodulators
Lipids
Materials
Membrane proteins
Membranes
Micelles
Microbial Genetics and Genomics
Microbial glycobiotechnology
Microbiological synthesis
Microbiology
Microscopy
Minimum inhibitory concentration
Molecular weight
Morphology
Nanoparticles
Nisin
Petrochemicals
Pharmaceuticals
Pharmacology
Post-harvest decay
Pseudomonas aeruginosa
Review
Rhamnolipids
Spore germination
Surface active agents
Surface tension
Surfactants
Therapeutic applications
Toxicity
India
Antimicrobial agents
Antitumor agents
Rhamnolipids
Biosurfactants
Immunomodulators
ISSN:1475-2859, 1475-2859
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Shrnutí:Rhamnolipids (RLs) are surface-active compounds and belong to the class of glycolipid biosurfactants, mainly produced from Pseudomonas aeruginosa . Due to their non-toxicity, high biodegradability, low surface tension and minimum inhibitory concentration values, they have gained attention in various sectors like food, healthcare, pharmaceutical and petrochemicals. The ecofriendly biological properties of rhamnolipids make them potent materials to be used in therapeutic applications. RLs are also known to induce apoptosis and thus, able to inhibit proliferation of cancer cells. RLs can also act as immunomodulators to regulate the humoral and cellular immune systems. Regarding their antimicrobial property, they lower the surface hydrophobicity, destruct the cytoplasmic membrane and lower the critical micelle concentration to kill the bacterial cells either alone or in combination with nisin possibly due to their role in modulating outer membrane protein. RLs are also involved in the synthesis of nanoparticles for in vivo drug delivery. In relation to economic benefits, the post-harvest decay of food can be decreased by RLs because they prevent the mycelium growth, spore germination of fungi and inhibit the emergence of biofilm formation on food. The present review focuses on the potential uses of RLs in cosmetic, pharmaceutical, food and health-care industries as the potent therapeutic agents.
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ISSN:1475-2859
1475-2859
DOI:10.1186/s12934-020-01497-9