Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction

The ribosome, the largest RNA-containing macromolecular machinery in cells, requires metal ions not only to maintain its three-dimensional fold but also to perform protein synthesis. Despite the vast biochemical data regarding the importance of metal ions for efficient protein synthesis and the incr...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 2519 - 12
Main Authors:	Rozov, Alexey, Khusainov, Iskander, El Omari, Kamel, Duman, Ramona, Mykhaylyk, Vitaliy, Yusupov, Marat, Westhof, Eric, Wagner, Armin, Yusupova, Gulnara
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07.06.2019 Nature Publishing Group Nature Portfolio
Subjects:	631/337/574/1789 631/535/1266 639/638/92/321/1156 Biochemistry, Molecular Biology Cations Chemical synthesis Cryoelectron Microscopy Crystallization Crystallography Crystallography, X-Ray Decoding Electron microscopy Escherichia coli Humanities and Social Sciences Ions Life Sciences Macromolecules Metal ions multidisciplinary Nucleic acids Potassium Potassium - metabolism Protein Biosynthesis Protein Conformation Protein folding Protein synthesis Proteins Ribonucleic acid Ribosomes - metabolism Ribosomes - ultrastructure RNA RNA, Transfer - metabolism Science Science (multidisciplinary) Structural Biology Structural integrity Structure-function relationships Thermus thermophilus - metabolism Wavelength X-ray crystallography X-Ray Diffraction
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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