Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial

Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent adverse effects related to concentration, which can cause treatment interruption. We aimed to ascertain whether adverse effects could be reduced...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 383; no. 9918; pp. 697 - 704
Main Authors:	Bateman, D Nicholas, Dear, James W, Thanacoody, H K Ruben, Thomas, Simon H L, Eddleston, Michael, Sandilands, Euan A, Coyle, Judy, Cooper, Jamie G, Rodriguez, Aryelly, Butcher, Isabella, Lewis, Steff C, Vliegenthart, A D Bastiaan, Veiraiah, Aravindan, Webb, David J, Gray, Alasdair
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 22.02.2014 Elsevier Elsevier Limited
Subjects:	Acetaminophen - antagonists & inhibitors Acetaminophen - poisoning Acetylcysteine Acetylcysteine - administration & dosage Acetylcysteine - adverse effects Adult Aged Alanine Alanine transaminase Alanine Transaminase - metabolism Analgesics Anaphylactoid reactions Antiemetics Antiemetics - administration & dosage Biological and medical sciences Blood pressure Case reports Double-Blind Method Drug Administration Schedule Drug dosages Drug overdose Drug Therapy, Combination Female General aspects Humans Infusions, Intravenous Internal Medicine Intravenous administration Liver Failure, Acute - chemically induced Liver Failure, Acute - prevention & control Male Medical prognosis Medical sciences Middle Aged Nausea - prevention & control Ondansetron - administration & dosage Overdose Paracetamol Patients Placebos Poisoning Poisoning - drug therapy Poisons Pretreatment Randomization Regulatory approval Risk assessment Side effects Statistical analysis Transaminases Treatment Outcome United Kingdom Vomiting Vomiting - chemically induced Vomiting - prevention & control United Kingdom > UK United States > US England Scotland Thiol Intravenous administration Toxicity Antimigrainous agent Acetylcysteine Antioxidant Randomized controlled trial Medicine Mucolytic Paracetamol Reduction Analgesic Treatment Antipyretic Secondary effect Clinical trial Poisoning
ISSN:	0140-6736, 1474-547X, 1474-547X
Online Access:	Get full text
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