Enveloped viruses distinct from HBV induce dissemination of hepatitis D virus in vivo

Hepatitis D virus (HDV) doesn’t encode envelope proteins for packaging of its ribonucleoprotein (RNP) and typically relies on the surface glycoproteins (GPs) from hepatitis B virus (HBV) for virion assembly, envelopment and cellular transmission. HDV RNA genome can efficiently replicate in different...

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Bibliographic Details
Published in:Nature communications Vol. 10; no. 1; pp. 2098 - 15
Main Authors: Perez-Vargas, Jimena, Amirache, Fouzia, Boson, Bertrand, Mialon, Chloé, Freitas, Natalia, Sureau, Camille, Fusil, Floriane, Cosset, François-Loïc
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 08.05.2019
Nature Publishing Group
Nature Portfolio
Subjects:
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Animals
Biological evolution
Cell Line, Tumor
Coinfection - transmission
Coinfection - virology
Disease transmission
Egress
Flavivirus - metabolism
Genomes
Glycoproteins
Helper viruses
Hepacivirus - metabolism
Hepacivirus - pathogenicity
Hepatitis
Hepatitis B
Hepatitis D - transmission
Hepatitis D - virology
Hepatitis delta virus
Hepatitis Delta Virus - isolation & purification
Hepatitis Delta Virus - pathogenicity
Hepatitis Delta Virus - physiology
Hepatocytes - transplantation
Hepatocytes - virology
Human health and pathology
Humanities and Social Sciences
Humans
Infectious diseases
Life Sciences
Mice
Mice, Inbred NOD
Mice, Transgenic
Microbiology and Parasitology
multidisciplinary
Packaging
Primary Cell Culture
Receptors
Ribonucleic acid
Ribonucleoproteins - metabolism
RNA
RNA, Viral - isolation & purification
Science
Science (multidisciplinary)
Vesiculovirus - metabolism
Viral Envelope Proteins - metabolism
Virion - metabolism
Virions
Virology
Virus Assembly
Viruses
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:Hepatitis D virus (HDV) doesn’t encode envelope proteins for packaging of its ribonucleoprotein (RNP) and typically relies on the surface glycoproteins (GPs) from hepatitis B virus (HBV) for virion assembly, envelopment and cellular transmission. HDV RNA genome can efficiently replicate in different tissues and species, raising the possibility that it evolved, and/or is still able to transmit, independently of HBV. Here we show that alternative, HBV-unrelated viruses can act as helper viruses for HDV. In vitro, envelope GPs from several virus genera, including vesiculovirus, flavivirus and hepacivirus, can package HDV RNPs, allowing efficient egress of HDV particles in the extracellular milieu of co-infected cells and subsequent entry into cells expressing the relevant receptors. Furthermore, HCV can propagate HDV infection in the liver of co-infected humanized mice for several months. Further work is necessary to evaluate whether HDV is currently transmitted by HBV-unrelated viruses in humans. Hepatitis D virus (HDV) relies on a helper virus to package and transmit its ribonucleoprotein (RNP). Here, Perez-Vargas et al. show that HDV can use envelope proteins from HBV-unrelated viruses, including HCV and flaviviruses, to propagate in vitro and in humanized mice.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-019-10117-z