Enveloped viruses distinct from HBV induce dissemination of hepatitis D virus in vivo

Hepatitis D virus (HDV) doesn’t encode envelope proteins for packaging of its ribonucleoprotein (RNP) and typically relies on the surface glycoproteins (GPs) from hepatitis B virus (HBV) for virion assembly, envelopment and cellular transmission. HDV RNA genome can efficiently replicate in different...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Nature communications Ročník 10; číslo 1; s. 2098 - 15
Hlavní autori:	Perez-Vargas, Jimena, Amirache, Fouzia, Boson, Bertrand, Mialon, Chloé, Freitas, Natalia, Sureau, Camille, Fusil, Floriane, Cosset, François-Loïc
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 08.05.2019 Nature Publishing Group Nature Portfolio
Predmet:	14 38 631/326/596/1550 631/326/596/1905 631/326/596/2563 692/699/255/234/2513 82/51 Animals Biological evolution Cell Line, Tumor Coinfection - transmission Coinfection - virology Disease transmission Egress Flavivirus - metabolism Genomes Glycoproteins Helper viruses Hepacivirus - metabolism Hepacivirus - pathogenicity Hepatitis Hepatitis B Hepatitis D - transmission Hepatitis D - virology Hepatitis delta virus Hepatitis Delta Virus - isolation & purification Hepatitis Delta Virus - pathogenicity Hepatitis Delta Virus - physiology Hepatocytes - transplantation Hepatocytes - virology Human health and pathology Humanities and Social Sciences Humans Infectious diseases Life Sciences Mice Mice, Inbred NOD Mice, Transgenic Microbiology and Parasitology multidisciplinary Packaging Primary Cell Culture Receptors Ribonucleic acid Ribonucleoproteins - metabolism RNA RNA, Viral - isolation & purification Science Science (multidisciplinary) Vesiculovirus - metabolism Viral Envelope Proteins - metabolism Virion - metabolism Virions Virology Virus Assembly Viruses
ISSN:	2041-1723, 2041-1723
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Hepatitis D virus (HDV) doesn’t encode envelope proteins for packaging of its ribonucleoprotein (RNP) and typically relies on the surface glycoproteins (GPs) from hepatitis B virus (HBV) for virion assembly, envelopment and cellular transmission. HDV RNA genome can efficiently replicate in different tissues and species, raising the possibility that it evolved, and/or is still able to transmit, independently of HBV. Here we show that alternative, HBV-unrelated viruses can act as helper viruses for HDV. In vitro, envelope GPs from several virus genera, including vesiculovirus, flavivirus and hepacivirus, can package HDV RNPs, allowing efficient egress of HDV particles in the extracellular milieu of co-infected cells and subsequent entry into cells expressing the relevant receptors. Furthermore, HCV can propagate HDV infection in the liver of co-infected humanized mice for several months. Further work is necessary to evaluate whether HDV is currently transmitted by HBV-unrelated viruses in humans. Hepatitis D virus (HDV) relies on a helper virus to package and transmit its ribonucleoprotein (RNP). Here, Perez-Vargas et al. show that HDV can use envelope proteins from HBV-unrelated viruses, including HCV and flaviviruses, to propagate in vitro and in humanized mice.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-019-10117-z