Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features

Background Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant research on tumour evolution in prostate cancer metastasis, the emergence and evolution of cancer clones at this early stage of expansion and s...

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Bibliographic Details
Published in:	Genome medicine Vol. 16; no. 1; pp. 35 - 18
Main Authors:	Rao, Srinivasa, Verrill, Clare, Cerundolo, Lucia, Alham, Nasullah Khalid, Kaya, Zeynep, O’Hanlon, Miriam, Hayes, Alicia, Lambert, Adam, James, Martha, Tullis, Iain D. C., Niederer, Jane, Lovell, Shelagh, Omer, Altan, Lopez, Francisco, Leslie, Tom, Buffa, Francesca, Bryant, Richard J., Lamb, Alastair D., Vojnovic, Boris, Wedge, David C., Mills, Ian G., Woodcock, Dan J., Tomlinson, Ian, Hamdy, Freddie C.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 19.02.2024 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adenocarcinoma Biobanks Bioinformatics Biomedical and Life Sciences Biomedicine Cancer Cancer evolution Cancer Research Care and treatment Copy number DNA sequencing Evolution Genetic aspects Genetic testing Genetic transformation Genome instability in cancer: from mechanisms to the clinic Genomes Genomics Histopathology Human Genetics Humans Intra-tumour heterogeneity Lymph nodes Lymphatic Metastasis - pathology Lymphatic system Male Malignancy Medical prognosis Medicine/Public Health Metabolomics Metastases Metastasis Mutation Nucleotide sequencing Patients Phylogeny Prostate - pathology Prostate cancer Prostate cancer metastasis Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Seminal vesicle Seminal Vesicles - pathology Spatial genomic analysis Systems Biology Tumors Vesicles Whole genome sequencing United Kingdom Prostate cancer metastasis Intra-tumour heterogeneity Spatial genomic analysis Histopathology Prostate cancer Cancer evolution
ISSN:	1756-994X, 1756-994X
Online Access:	Get full text
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