Extracellular vesicle PD-L1 dynamics predict durable response to immune-checkpoint inhibitors and survival in patients with non-small cell lung cancer

Background Immune-checkpoint inhibitors (ICIs) changed the therapeutic landscape of patients with lung cancer. However, only a subset of them derived clinical benefit and evidenced the need to identify reliable predictive biomarkers. Liquid biopsy is the non-invasive and repeatable analysis of biolo...

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Veröffentlicht in:	Journal of experimental & clinical cancer research Jg. 41; H. 1; S. 186 - 14
Hauptverfasser:	de Miguel-Perez, Diego, Russo, Alessandro, Arrieta, Oscar, Ak, Murat, Barron, Feliciano, Gunasekaran, Muthukumar, Mamindla, Priyadarshini, Lara-Mejia, Luis, Peterson, Christine B., Er, Mehmet E., Peddagangireddy, Vishal, Buemi, Francesco, Cooper, Brandon, Manca, Paolo, Lapidus, Rena G., Hsia, Ru-Ching, Cardona, Andres F., Naing, Aung, Kaushal, Sunjay, Hirsch, Fred R., Mack, Philip C., Serrano, Maria Jose, Adamo, Vincenzo, Colen, Rivka R., Rolfo, Christian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 02.06.2022 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	Apoptosis B7-H1 Antigen - metabolism Biomarkers Biomedical and Life Sciences Biomedicine Biopsy Cancer Research Cancer therapies Carcinoma, Non-Small-Cell Lung - pathology Development and progression Extracellular vesicles Extracellular Vesicles - metabolism Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - therapeutic use Immune response Immunology Immunotherapy Lung cancer Lung cancer, Non-small cell Lung cancer, Small cell Lung Neoplasms Medical imaging Metastasis NSCLC Oncology Patient outcomes PD-L1 Performance evaluation Prognosis Prospective Studies Retrospective Studies Software Statistical analysis Tumors United States > US Extracellular vesicles PD-L1 Biomarkers NSCLC Immunotherapy
ISSN:	1756-9966, 0392-9078, 1756-9966
Online-Zugang:	Volltext
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