Clinical application of free-breathing 3D whole heart late gadolinium enhancement cardiovascular magnetic resonance with high isotropic spatial resolution using Compressed SENSE

Background Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) represents the gold standard for assessment of myocardial viability. The purpose of this study was to investigate the clinical potential of Compressed SENSE (factor 5) accelerated free-breathing three-dimensional (3...

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Vydáno v:Journal of cardiovascular magnetic resonance Ročník 22; číslo 1; s. 89 - 13
Hlavní autoři: Pennig, Lenhard, Lennartz, Simon, Wagner, Anton, Sokolowski, Marcel, Gajzler, Matej, Ney, Svenja, Laukamp, Kai Roman, Persigehl, Thorsten, Bunck, Alexander Christian, Maintz, David, Weiss, Kilian, Naehle, Claas Philip, Doerner, Jonas
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 17.12.2020
BioMed Central Ltd
Elsevier
Témata:
Adolescent
Adult
Aged
Aged, 80 and over
Angiology
Body mass index
Body size
Cardiology
Cardiomyopathies - diagnostic imaging
Cardiomyopathies - pathology
Cardiomyopathy
Cardiovascular magnetic resonance
Comparative analysis
Contrast Media
Databases, Factual
Diagnostic systems
Electrocardiography
Evaluation
Female
Gadobutrol
Gadolinium
Heart beat
Heart rate
Heart Ventricles - diagnostic imaging
Heart Ventricles - pathology
Humans
Image quality
Imaging
Imaging, Three-Dimensional
Ischemia
Late gadolinium enhancement
Lesions
Localization
Magnetic resonance
Magnetic Resonance Imaging, Cine
Male
Medical imaging
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Myocardium - pathology
Observer Variation
Organometallic Compounds
Predictive Value of Tests
Radiology
Regression analysis
Reproducibility of Results
Respiration
Retrospective Studies
Spatial discrimination
Spatial resolution
Tissue Survival
Ventricle
Young Adult
Cardiovascular magnetic resonance
Late gadolinium enhancement
Cardiomyopathy
ISSN:1097-6647, 1532-429X, 1532-429X
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Shrnutí:Background Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) represents the gold standard for assessment of myocardial viability. The purpose of this study was to investigate the clinical potential of Compressed SENSE (factor 5) accelerated free-breathing three-dimensional (3D) whole heart LGE with high isotropic spatial resolution (1.4 mm 3 acquired voxel size) compared to standard breath-hold LGE imaging. Methods This was a retrospective, single-center study of 70 consecutive patients (45.8 ± 18.1 years, 27 females; February–November 2019), who were referred for assessment of left ventricular myocardial viability and received free-breathing and breath-hold LGE sequences at 1.5 T in clinical routine. Two radiologists independently evaluated global and segmental LGE in terms of localization and transmural extent. Readers scored scans regarding image quality (IQ), artifacts, and diagnostic confidence (DC) using 5-point scales (1 non-diagnostic—5 excellent/none). Effects of heart rate and body mass index (BMI) on IQ, artifacts, and DC were evaluated with ordinal logistic regression analysis. Results Global LGE (n = 33) was identical for both techniques. Using free-breathing LGE (average scan time: 04:33 ± 01:17 min), readers detected more hyperenhanced lesions (28.2% vs. 23.5%, P < .05) compared to breath-hold LGE (05:15 ± 01:23 min, P = .0104), pronounced at subepicardial localization and for 1–50% of transmural extent. For free-breathing LGE, readers graded scans with good/excellent IQ in 80.0%, with low-impact/no artifacts in 78.6%, and with good/high DC in 82.1% of cases. Elevated BMI was associated with increased artifacts (P = .0012) and decreased IQ (P = .0237). Increased heart rate negatively influenced artifacts (P = .0013) and DC (P = .0479) whereas IQ (P = .3025) was unimpaired. Conclusions In a clinical setting, free-breathing Compressed SENSE accelerated 3D high isotropic spatial resolution whole heart LGE provides good to excellent image quality in 80% of scans independent of heart rate while enabling improved depiction of small and particularly non-ischemic hyperenhanced lesions in a shorter scan time than standard breath-hold LGE.
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ISSN:1097-6647
1532-429X
1532-429X
DOI:10.1186/s12968-020-00673-5