Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

The cytotoxic effects of topoisomerase I inhibitors such as camptothecin can be modulated by replication fork reversal, in a process that requires Poly(ADP-ribose) polymerase (PARP) activity. Here human RECQ1 helicase is shown to restore such regressed replication forks, whereas PARP1 activity restr...

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Veröffentlicht in:	Nature structural & molecular biology Jg. 20; H. 3; S. 347 - 354
Hauptverfasser:	Berti, Matteo, Ray Chaudhuri, Arnab, Thangavel, Saravanabhavan, Gomathinayagam, Shivasankari, Kenig, Sasa, Vujanovic, Marko, Odreman, Federico, Glatter, Timo, Graziano, Simona, Mendoza-Maldonado, Ramiro, Marino, Francesca, Lucic, Bojana, Biasin, Valentina, Gstaiger, Matthias, Aebersold, Ruedi, Sidorova, Julia M, Monnat, Raymond J, Lopes, Massimo, Vindigni, Alessandro
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.03.2013 Nature Publishing Group
Schlagworte:	631/337/151 631/45/173 631/92/609 Adenosine diphosphate Biochemistry Biological Microscopy Camptothecin - pharmacology Cancer Cell Line Cytotoxicity Deoxyribonucleic acid DNA DNA Replication DNA Topoisomerases, Type I - metabolism Enzymes Gene expression Genetic aspects Humans Inhibitor drugs Inhibitors Life Sciences Membrane Biology Molecular biology Pharmacology Physiological aspects Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Protein Structure RecQ Helicases - genetics RecQ Helicases - metabolism Structure Topoisomerase I Inhibitors - pharmacology Topoisomerases United States
ISSN:	1545-9993, 1545-9985, 1545-9985
Online-Zugang:	Volltext
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