Targeted next generation sequencing as a tool for precision medicine

Background Targeted next-generation sequencing (NGS) enables rapid identification of common and rare genetic variation. The detection of variants contributing to therapeutic drug response or adverse effects is essential for implementation of individualized pharmacotherapy. Successful application of...

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Bibliographic Details
Published in:	BMC medical genomics Vol. 12; no. 1; pp. 81 - 17
Main Authors:	Gulilat, Markus, Lamb, Tyler, Teft, Wendy A., Wang, Jian, Dron, Jacqueline S., Robinson, John F., Tirona, Rommel G., Hegele, Robert A., Kim, Richard B., Schwarz, Ute I.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 03.06.2019 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adult Algorithms Alleles Anticoagulants Bioinformatics Biomarkers Biomedical and Life Sciences Biomedicine Child Computational biology Computer Simulation Consortia Copy number Copy number variation CYP2D6 protein Cytochrome Cytochrome P-450 Cytochrome P-450 CYP2D6 - genetics Cytochrome P450 Data processing Deoxyribonucleic acid DNA DNA Copy Number Variations DNA probes DNA sequencing Drug dosages Drug therapy Enzymes Gene Expression Gene frequency Gene polymorphism Genes Genetic diversity Genetic variation Genomes Genomics Genotype & phenotype Genotyping Glucuronosyltransferase Glucuronosyltransferase - genetics High-Throughput Nucleotide Sequencing Homology Human Genetics Humans In silico prediction Metabolism Microarrays Molecular Sequence Annotation Next generation sequencing Novels Pediatrics Pharmacogenes Polymorphism Population genetics Precision medicine Precision Medicine - methods Prognostics and diagnostics/biomarkers Pseudogenes Targeted exome sequencing Technical Advance Pharmacogenes Copy number variation Next generation sequencing Targeted exome sequencing In silico prediction
ISSN:	1755-8794, 1755-8794
Online Access:	Get full text
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