The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways

[Display omitted] •The GLP-1RAs liraglutide and semaglutide reduce cardiovascular risk in type 2 diabetes patients.•In ApoE−/− mice and LDLr−/− mice, liraglutide and semaglutide treatment significantly attenuated plaque lesion development, in part independently of body weight and cholesterol lowerin...

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Veröffentlicht in:	JACC. Basic to translational science Jg. 3; H. 6; S. 844 - 857
Hauptverfasser:	Rakipovski, Günaj, Rolin, Bidda, Nøhr, Jane, Klewe, Ib, Frederiksen, Klaus S., Augustin, Robert, Hecksher-Sørensen, Jacob, Ingvorsen, Camilla, Polex-Wolf, Joseph, Knudsen, Lotte Bjerre
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.12.2018 Elsevier
Schlagworte:	atherosclerosis Cardiovascular diabetes GLP-1 inflammation obesity PRECLINICAL RESEARCH atherosclerosis CD163 GLP-1 IL RNA GLP NASH OPN TNF WD LPS IFN MMP inflammation LDL diabetes obesity TIMP cluster of differentiation 163 molecule ribonucleic acid nonalcoholic steatohepatitis tissue inhibitor of metalloproteinases glucagon-like peptide interleukin osteopontin interferon low-density lipoprotein tumor necrosis factor matrix metalloproteinase lipopolysaccharide Western diet IFN, interferon CD163, cluster of differentiation 163 molecule RNA, ribonucleic acid TNF, tumor necrosis factor OPN, osteopontin NASH, nonalcoholic steatohepatitis IL, interleukin LPS, lipopolysaccharide WD, Western diet TIMP, tissue inhibitor of metalloproteinases LDL, low-density lipoprotein MMP, matrix metalloproteinase GLP, glucagon-like peptide
ISSN:	2452-302X, 2452-302X
Online-Zugang:	Volltext
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