Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism

Complexes containing a pair of structural maintenance of chromosomes (SMC) family proteins are fundamental for the three-dimensional (3D) organization of genomes in all domains of life. The eukaryotic SMC complexes cohesin and condensin are thought to fold interphase and mitotic chromosomes, respect...

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Veröffentlicht in:	Nature structural & molecular biology Jg. 27; H. 8; S. 743 - 751
Hauptverfasser:	Lee, Byung-Gil, Merkel, Fabian, Allegretti, Matteo, Hassler, Markus, Cawood, Christopher, Lecomte, Léa, O'Reilly, Francis J, Sinn, Ludwig R, Gutierrez-Escribano, Pilar, Kschonsak, Marc, Bravo, Sol, Nakane, Takanori, Rappsilber, Juri, Aragon, Luis, Beck, Martin, Löwe, Jan, Haering, Christian H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Nature Publishing Group 01.08.2020
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - metabolism Adenosine Triphosphatases - ultrastructure Adenosine triphosphate Adenosine Triphosphate - metabolism Binding sites Carrier Proteins - chemistry Carrier Proteins - metabolism Carrier Proteins - ultrastructure Cell Cycle Proteins Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - metabolism Chromosomal Proteins, Non-Histone - ultrastructure Chromosomes Cohesin Coils Condensin Conformation Cryoelectron Microscopy Deoxyribonucleic acid DNA DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism DNA-Binding Proteins - ultrastructure Domains Extrusion Genomes Heat exchange Models, Molecular Molecular modelling Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Multiprotein Complexes - ultrastructure Nuclear Proteins - chemistry Nuclear Proteins - metabolism Nuclear Proteins - ultrastructure Nucleotides Open architectures Protein Conformation Protein Folding Protein Multimerization Saccharomyces cerevisiae Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Saccharomyces cerevisiae Proteins - ultrastructure Translocation Yeast
ISSN:	1545-9993, 1545-9985, 1545-9985
Online-Zugang:	Volltext
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