Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms

The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and microvascular complications associated with diabetes mellitus. AGEs result from the nonenzymatic reaction of reducing sugars with proteins, lipids, and nucleic a...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Molecular metabolism (Germany) Ročník 3; číslo 2; s. 94 - 108
Hlavní autoři: Stirban, Alin, Gawlowski, Thomas, Roden, Michael
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany Elsevier GmbH 01.04.2014
Elsevier
Témata:
Advanced glycation endproducts
Endocrinology & Metabolism
Endothelium
Review
Vascular
Advanced glycation endproducts
Vascular
Endothelium
ISSN:2212-8778, 2212-8778
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and microvascular complications associated with diabetes mellitus. AGEs result from the nonenzymatic reaction of reducing sugars with proteins, lipids, and nucleic acids, potentially altering their function by disrupting molecular conformation, promoting cross-linking, altering enzyme activity, reducing their clearance, and impairing receptor recognition. AGEs may also activate specific receptors, like the receptor for AGEs (RAGE), which is present on the surface of all cells relevant to atherosclerotic processes, triggering oxidative stress, inflammation and apoptosis. Understanding the pathogenic mechanisms of AGEs is paramount to develop strategies against diabetic and cardiovascular complications.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2212-8778
2212-8778
DOI:10.1016/j.molmet.2013.11.006