Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms

The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and microvascular complications associated with diabetes mellitus. AGEs result from the nonenzymatic reaction of reducing sugars with proteins, lipids, and nucleic a...

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Bibliographic Details
Published in:Molecular metabolism (Germany) Vol. 3; no. 2; pp. 94 - 108
Main Authors: Stirban, Alin, Gawlowski, Thomas, Roden, Michael
Format: Journal Article
Language:English
Published: Germany Elsevier GmbH 01.04.2014
Elsevier
Subjects:
Advanced glycation endproducts
Endocrinology & Metabolism
Endothelium
Review
Vascular
Advanced glycation endproducts
Vascular
Endothelium
ISSN:2212-8778, 2212-8778
Online Access:Get full text
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Summary:The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and microvascular complications associated with diabetes mellitus. AGEs result from the nonenzymatic reaction of reducing sugars with proteins, lipids, and nucleic acids, potentially altering their function by disrupting molecular conformation, promoting cross-linking, altering enzyme activity, reducing their clearance, and impairing receptor recognition. AGEs may also activate specific receptors, like the receptor for AGEs (RAGE), which is present on the surface of all cells relevant to atherosclerotic processes, triggering oxidative stress, inflammation and apoptosis. Understanding the pathogenic mechanisms of AGEs is paramount to develop strategies against diabetic and cardiovascular complications.
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ISSN:2212-8778
2212-8778
DOI:10.1016/j.molmet.2013.11.006