Novel rechargeable calcium phosphate dental nanocomposite

Calcium phosphate (CaP) composites with Ca and P ion release can remineralize tooth lesions and inhibit caries. But the ion release lasts only a few months. The objectives of this study were to develop rechargeable CaP dental composite for the first time, and investigate the Ca and P recharge and re...

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Vydáno v:Dental materials Ročník 32; číslo 2; s. 285 - 293
Hlavní autoři: Zhang, Ling, Weir, Michael D., Chow, Laurence C., Antonucci, Joseph M., Chen, Jihua, Xu, Hockin H.K.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.02.2016
Témata:
Advanced Basic Science
Benzoates - chemistry
BisGMA
Bisphenol A
Bisphenol A-Glycidyl Methacrylate - chemistry
Calcium phosphate
Calcium phosphate ion release
Calcium phosphate nanoparticles
Calcium Phosphates - chemistry
Composite Resins - chemical synthesis
Composite Resins - chemistry
Dental Caries - prevention & control
Dental caries inhibition
Dental composite
Dental materials
Dental Materials - chemistry
Dentistry
Elastic Modulus
Glass
Materials Testing
Methacrylates - chemistry
Nanocomposites
Nanocomposites - chemistry
Polyethylene Glycols - chemistry
Polymethacrylic Acids - chemistry
Recharge
Recharging
Remineralization
Resins
Calcium phosphate ion release
Dental caries inhibition
Recharge
Calcium phosphate nanoparticles
Dental composite
Remineralization
ISSN:0109-5641, 1879-0097, 1879-0097
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Shrnutí:Calcium phosphate (CaP) composites with Ca and P ion release can remineralize tooth lesions and inhibit caries. But the ion release lasts only a few months. The objectives of this study were to develop rechargeable CaP dental composite for the first time, and investigate the Ca and P recharge and re-release of composites with nanoparticles of amorphous calcium phosphate (NACP) to achieve long-term inhibition of caries. Three NACP nanocomposites were fabricated with resin matrix of: (1) bisphenol A glycidyl dimethacrylate (BisGMA) and triethylene glycol dimethacrylate (TEGDMA) at 1:1 mass ratio (referred to as BT group); (2) pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA) at 1:1 ratio (PE group); (3) BisGMA, TEGDMA, and Bis[2-(methacryloyloxy)ethyl] phosphate (BisMEP) at 2:1:1 ratio (BTM group). Each resin was filled with 20% NACP and 50% glass particles, and the composite was photo-cured. Specimens were tested for flexural strength and elastic modulus, Ca and P ion release, and Ca and P ion recharge and re-release. NACP nanocomposites had strengths 3-fold of, and elastic moduli similar to, commercial resin-modified glass ionomer controls. CaP ion recharge capability was the greatest for PE group, followed by BTM group, with BT group being the lowest (p<0.05). For each recharge cycle, CaP re-release reached similarly high levels, showing that CaP re-release did not decrease with more recharge cycles. After six recharge/re-release cycles, NACP nanocomposites without further recharge had continuous CaP ion release for 42 d. Novel rechargeable CaP composites achieved long-term and sustained Ca and P ion release. Rechargeable NACP nanocomposite is promising for caries-inhibiting restorations, and the Ca and P ion recharge and re-release method has wide applicability to dental composites, adhesives, cements and sealants to achieve long-term caries-inhibition.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0109-5641
1879-0097
1879-0097
DOI:10.1016/j.dental.2015.11.015