Stability of neuropsychological test performance in older adults serving as normative controls for a study on postoperative cognitive dysfunction

Objective Studies of postoperative cognitive dysfunction (POCD) rely on repeat neuropsychological testing. The stability of the applied instruments, which are affected by natural variability in performance and measurement imprecision, is often unclear. We determined the stability of a neuropsycholog...

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Published in:BMC research notes Vol. 13; no. 1; pp. 55 - 6
Main Authors: Feinkohl, Insa, Borchers, Friedrich, Burkhardt, Sarah, Krampe, Henning, Kraft, Antje, Speidel, Saya, Kant, Ilse M. J., van Montfort, Simone J. T., Aarts, Ellen, Kruppa, Jochen, Slooter, Arjen, Winterer, Georg, Pischon, Tobias, Spies, Claudia
Format: Journal Article
Language:English
Published: London BioMed Central 04.02.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Algorithms
Batteries
Biomedical and Life Sciences
Biomedicine
Cognitive ability
Cognitive ageing
Cognitive disorders
Comparative analysis
Computerized testing
Confidence intervals
Life Sciences
Measuring techniques
Medicine/Public Health
Memory
Neuropsychological testing
Older people
Postoperative cognitive dysfunction
Psychology
Research Note
Studies
Surgery
Test–retest reliability
Time
Test–retest reliability
Cognitive ageing
Neuropsychological testing
Postoperative cognitive dysfunction
Computerized testing
ISSN:1756-0500, 1756-0500
Online Access:Get full text
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Summary:Objective Studies of postoperative cognitive dysfunction (POCD) rely on repeat neuropsychological testing. The stability of the applied instruments, which are affected by natural variability in performance and measurement imprecision, is often unclear. We determined the stability of a neuropsychological test battery using a sample of older adults from the general population. Forty-five participants aged 65 to 89 years performed six computerized and non-computerized neuropsychological tests at baseline and again at 7 day and 3 months follow-up sessions. Mean scores on each test were compared across time points using repeated measures analyses of variance (ANOVA) with pairwise comparison. Two-way mixed effects, absolute agreement analyses of variance intra-class correlation coefficients (ICC) determined test–retest reliability. Results All tests had moderate to excellent test–retest reliability during 7-day (ICC range 0.63 to 0.94; all p < 0.01) and 3-month intervals (ICC range 0.60 to 0.92; all p < 0.01) though confidence intervals of ICC estimates were large throughout. Practice effects apparent at 7 days eased off by 3 months. No substantial differences between computerized and non-computerized tests were observed. We conclude that the present six-test neuropsychological test battery is appropriate for use in POCD research though small sample size of our study needs to be recognized as a limitation. Trial registration ClinicalTrials.gov Identifier NCT02265263 (15th October 2014)
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ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-020-4919-3