A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion

Ischemia/reperfusion injury is a major cause of acute kidney injury. Improving renal repair would represent a therapeutic strategy to prevent renal dysfunction. The innate immune receptor Nlrp3 is involved in tissue injury, inflammation, and fibrosis; however, its role in repair after ischemia/reper...

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Bibliographic Details
Published in:	The American journal of pathology Vol. 184; no. 7; p. 2013
Main Authors:	Bakker, Pieter J, Butter, Loes M, Claessen, Nike, Teske, Gwendoline J D, Sutterwala, Fayyaz S, Florquin, Sandrine, Leemans, Jaklien C
Format:	Journal Article
Language:	English
Published:	United States 01.07.2014
Subjects:	Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Animals Apoptosis Bone Marrow Transplantation Carrier Proteins - metabolism Cell Hypoxia Cell Proliferation Epithelial Cells - cytology Interleukin-1beta - metabolism Kidney Tubules - cytology Kidney Tubules - metabolism Kidney Tubules - pathology Leukocytes - metabolism Male Mice, Inbred C57BL Mice, Knockout NLR Family, Pyrin Domain-Containing 3 Protein Reperfusion Injury - metabolism
ISSN:	1525-2191, 1525-2191
Online Access:	Get more information
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