Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition

[Display omitted] •YAP is activated by myocardial infarction or neuroendocrine stimulation in cardiac fibroblasts.•Active YAP promotes TEA domain transcription factor-1–mediated transcription of myocardin-related transcription factor A to facilitate cardiac myofibroblast differentiation and extracel...

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Bibliographic Details
Published in:	JACC. Basic to translational science Vol. 5; no. 9; pp. 931 - 945
Main Authors:	Francisco, Jamie, Zhang, Yu, Jeong, Jae Im, Mizushima, Wataru, Ikeda, Shohei, Ivessa, Andreas, Oka, Shinichi, Zhai, Peiyong, Tallquist, Michelle D., Del Re, Dominic P.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.09.2020 Elsevier
Subjects:	cardiac fibrosis Cardiovascular heart failure Hippo signaling myocardial infarction Preclinical Research YAP heart failure Hippo signaling NRCF MRTF-A SMA myocardial infarction Mkl1 YAP mRNA TGF TEAD cardiac fibrosis PE MCM PDGFR MI AngII myocardin-related transcription factor A neonatal rat cardiac fibroblast Mer-Cre-Mer phenylephrine platelet-derived growth factor receptor messenger ribonucleic acid yes-associated protein megakaryoblastic leukemia 1 TEA domain transcription factor angiotensin II transforming growth factor smooth muscle actin NRCF, neonatal rat cardiac fibroblast MRTF-A, myocardin-related transcription factor A Mkl1, megakaryoblastic leukemia 1 YAP, yes-associated protein MI, myocardial infarction PDGFR, platelet-derived growth factor receptor SMA, smooth muscle actin TGF, transforming growth factor MCM, Mer-Cre-Mer PE, phenylephrine AngII, angiotensin II TEAD, TEA domain transcription factor mRNA, messenger ribonucleic acid
ISSN:	2452-302X, 2452-302X
Online Access:	Get full text
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