SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

[Display omitted] •SARS-CoV-2 directly infects cardiomyocytes in patients with COVID-19 myocarditis and does not infect cardiac macrophages, fibroblasts, or endothelial cells.•COVID-19 myocarditis is characterized by a myeloid-rich inflammatory infiltrate.•SARS-CoV-2 infects cardiomyocytes through a...

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Veröffentlicht in:	JACC. Basic to translational science Jg. 6; H. 4; S. 331 - 345
Hauptverfasser:	Bailey, Adam L., Dmytrenko, Oleksandr, Greenberg, Lina, Bredemeyer, Andrea L., Ma, Pan, Liu, Jing, Penna, Vinay, Winkler, Emma S., Sviben, Sanja, Brooks, Erin, Nair, Ajith P., Heck, Kent A., Rali, Aniket S., Simpson, Leo, Saririan, Mehrdad, Hobohm, Dan, Stump, W. Tom, Fitzpatrick, James A., Xie, Xuping, Zhang, Xianwen, Shi, Pei-Yong, Hinson, J. Travis, Gi, Weng-Tein, Schmidt, Constanze, Leuschner, Florian, Lin, Chieh-Yu, Diamond, Michael S., Greenberg, Michael J., Lavine, Kory J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.04.2021 Elsevier
Schlagworte:	cardiomyocyte Cardiovascular Clinical Research coronavirus disease 2019 engineered heart tissue myocarditis severe acute respiratory syndrome coronavirus 2 COVID-19 EHT ACE2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 coronavirus disease 2019 myocarditis cardiomyocyte hPSC engineered heart tissue LV coronavirus disease-2019 human pluripotent stem cell(s) left ventricle engineered heart tissues angiotensin converting enzyme 2 severe acute respiratory syndrome-coronavirus-2 ACE2, angiotensin converting enzyme 2 LV, left ventricle COVID-19, coronavirus disease-2019 SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2 hPSC, human pluripotent stem cell(s) EHT, engineered heart tissues
ISSN:	2452-302X, 2452-302X
Online-Zugang:	Volltext
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